Abstract: The present disclosure is directed to systems and methods for maintaining an environment within the interstitial space between a cleanroom worker and a cleanroom garment worn by the cleanroom worker. An air mover draws relatively cool air from the external cleanroom environment and discharges the air through one or more diffusers positioned in the interstitial space between the cleanroom worker and the cleanroom garment worn by the cleanroom worker. The one or more diffusers are positioned proximate the body of the cleanroom worker. Control circuitry monitors the temperature and relative humidity within the cleanroom garment and selectively controls the operation of the air mover to maintain a comfortable environment within the cleanroom garment even when PPE such as splash aprons, boots, gloves, and protective headgear are donned by the cleanroom worker. Reducing perspiration beneficially reduces the likelihood of contamination within the cleanroom environment.