Patents by Inventor Giorgio BERARDI

Giorgio BERARDI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate having high purity
    Patent number: 12129224
    Abstract: A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl[4-(hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product having an amount of any single unknown impurity equal to or less than 0.10%, as well as a product having a purity greater than 99.5%, preferably equal to or greater than 99.6%. An HPLC method for determining the purity of the product and possible impurities thereof is also described.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: October 29, 2024
    Assignee: ITALFARMACO SPA
    Inventors: Stefano Turchetta, Maurizio Zenoni, Elio Ullucci, Stefania Cocciolo, Giorgio Berardi, Nakia Maulucci
  • Process for preparing {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate having high purity
    Publication number: 20230348368
    Abstract: A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product having an amount of any single unknown impurity equal to or less than 0.10%, as well as a product having a purity greater than 99.5%, preferably equal to or greater than 99.6%. An HPLC method for determining the purity of the product and possible impurities thereof is also described.
    Type: Application
    Filed: June 21, 2023
    Publication date: November 2, 2023
    Inventors: Stefano TURCHETTA, Maurio ZENONI, Elio ULLUCCI, Stefania COCCIOLO, Giorgio Berardi, Nakia MAULUCCI
  • Process for preparing {6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate having high purity
    Publication number: 20220177421
    Abstract: A process for obtaining {{6-[(diethylamino)methyl]naphthalen-2-yl}methyl [4-(hydroxycarbamoyl)phenyl]carbamate and/or pharmaceutically acceptable salts thereof having high purity is described. This process allows to obtain a product having an amount of any single unknown impurity equal to or less than 0.10%, as well as a product having a purity greater than 99.5%, preferably equal to or greater than 99.6%. An HPLC method for determining the purity of the product and possible impurities thereof is also described.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 9, 2022
    Inventors: Stefano TURCHETTA, Maurizio ZENONI, Elio ULLUCCI, Stefania COCCIOLO, Giorgio BERARDI, Nakia MAULUCCI
  • Process for the synthesis of azacitidine and decitabine
    Patent number: 9266863
    Abstract: Described herein is a process for the synthesis of azacitidine or decitabine, comprising the silylation of azacytosine in the presence of N,O-bis-trimethylsilyl-trifluoroacetamide. Such reaction is performed in an organic solvent, preferably aprotic, even more preferably selected from among dichloromethane, dichloroethane and/or acetonitrile. According to a further aspect of the process, 2 to 3 moles of N,O-bis-trimethylsilyl-trifluoroacetamide are used per mole of azacytosine, preferably from 2.2 to 2.5.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: February 23, 2016
    Assignee: CHEMI SPA
    Inventors: Lorenzo De Ferra, Maurizio Zenoni, Stefano Turchetta, Mauro Anibaldi, Ettore Ammirati, Paolo Brandi, Giorgio Berardi
  • Bortezomib esters and formulations thereof
    Patent number: 9206229
    Abstract: Bortezomib esters with tartaric acid wherein the molar ratio between bortezomib and tartaric acid is 2:1 and formulations containing them are described.
    Type: Grant
    Filed: August 1, 2013
    Date of Patent: December 8, 2015
    Assignee: CHEMI S.P.A.
    Inventors: Stefano Turchetta, Maurizio Zenoni, Umberto Ciambecchini, Paolo Brandi, Vincenzo De Sio, Giorgio Berardi
  • Bortezomib Esters And Formulations Thereof
    Publication number: 20150232508
    Abstract: Bortezomib esters with tartaric acid wherein the molar ratio between bortezomib and tartaric acid is 2:1 and formulations containing them are described.
    Type: Application
    Filed: August 1, 2013
    Publication date: August 20, 2015
    Inventors: Stefano Turchetta, Maurizio Zenoni, Umberto Ciambecchini, Paolo Brandi, Vincenzo De Sio, Giorgio Berardi
  • PROCESS FOR THE SYNTHESIS OF AZACITIDINE AND DECITABINE
    Publication number: 20110245485
    Abstract: Described herein is a process for the synthesis of azacitidine or decitabine, comprising the silylation of azacytosine in the presence of N,O-bis-trimethylsilyl-trifluoroacetamide. Such reaction is performed in an organic solvent, preferably aprotic, even more preferably selected from among dichloromethane, dichloroethane and/or acetonitrile. According to a further aspect of the process, 2 to 3 moles of N,O-bis-trimethylsilyl-trifluoroacetamide are used per mole of azacytosine, preferably from 2.2 to 2.5.
    Type: Application
    Filed: March 28, 2011
    Publication date: October 6, 2011
    Applicant: CHEMI SPA
    Inventors: Lorenzo DE FERRA, Maurizio ZENONI, Stefano TURCHETTA, Mauro ANIBALDI, Ettore AMMIRATI, Paolo BRANDI, Giorgio BERARDI