Patents by Inventor Giorgio Bertolini

Giorgio Bertolini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11325922
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: May 10, 2022
    Assignee: OLON S.P.A.
    Inventors: Federico Gassa, Lazzaro Feliciani, Alberto Mazza, Marco Quaroni, Mara Sada, Giorgio Bertolini
  • Publication number: 20210246123
    Abstract: The invention relates to a process for the preparation of Lifitegrast of formula (I), which comprises: a) condensation of the compound of formula (II) with the compound of formula (III) to give the compound of formula (IV) wherein R1, R2 and R3 are independently selected from straight or branched C1-C6 alkyl groups; b) chlorination of compound (IV) in the presence of a chlorinating agent (IV), (V), c) condensation of compound (V) with amino acid (VI) to give compound (I), c) condensation of compound (V) with amino acid (VI) to give compound (I), d) optional purification of the crude Lifitegrast in mixtures of polar aprotic solvents and water.
    Type: Application
    Filed: June 13, 2019
    Publication date: August 12, 2021
    Applicant: OLON S.P.A.
    Inventors: Giorgio Bertolini, Lazzaro Feliciani, Davide Longoni, Mara Sada, Matteo Valli
  • Patent number: 11053227
    Abstract: Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: July 6, 2021
    Assignee: OLON S.P.A.
    Inventors: Corrado Colli, Giorgio Bertolini, Mara Sada, Faris Garis, Filippo Nisic, Aldo Bianchi, Cinzia Biaggi, Romano Di Fabio, Silvano Ronzoni, Stefania Bertuolo, Adolfo Prandi, Stefano Maiorana
  • Patent number: 11028082
    Abstract: The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: June 8, 2021
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Filippo Nisic, Mara Sada, Stefania Bertuolo, Silvano Ronzoni, Stefano Maiorana, Romano Di Fabio
  • Publication number: 20210070781
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: June 25, 2018
    Publication date: March 11, 2021
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • Publication number: 20210061757
    Abstract: Subject-matter of the present invention is a process for the preparation of optically active phenyl-beta-amino alcohols by means of a specific reduction of the corresponding phenyl-beta-amino ketones. Further subject-matter of the invention are said novel synthesis intermediates and their use for the preparation of active pharmaceutical ingredients.
    Type: Application
    Filed: April 11, 2019
    Publication date: March 4, 2021
    Inventors: Filippo NISIC, Faris GARIS, Corrado COLLI, Giorgio BERTOLINI, Mara SADA, Stefania BERTUOLO, Silvano RONZONI, Romano DI FABIO, Stefano MAIORANA
  • Publication number: 20200407377
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: July 10, 2020
    Publication date: December 31, 2020
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • Publication number: 20200385366
    Abstract: Subject-matter of the present invention is a process for preparing intermediates for the synthesis of optically active beta-amino alcohols by enzymatic reduction of the corresponding beta-amino ketones. Subject-matter of the invention are also said novel synthesis intermediates and the use thereof in the preparation of active pharmaceutical ingredients, among which vilanterol and the salts thereof.
    Type: Application
    Filed: December 19, 2018
    Publication date: December 10, 2020
    Inventors: Corrado COLLI, Giorgio BERTOLINI, Mara SADA, Faris GARIS, Filippo NISIC, Aldo BIANCHI, Cinzia BIAGGI, Romano DI FABIO, Silvano RONZONI, Stefania BERTUOLO, Adolfo PRANDI, Stefano MAIORANA
  • Publication number: 20200102300
    Abstract: The present invention relates to a process for the preparation of a novel and versatile synthesis intermediate and its use in the preparation of umeclidinium. The invention also relates to some reference standards allowing to detect impurity traces recurring in the preparation of umeclidinium and a process for their preparation.
    Type: Application
    Filed: May 28, 2018
    Publication date: April 2, 2020
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Filippo NISIC, Mara SADA, Stefania BERTUOLO, Silvano RONZONI, Stefano MAIORANA, Romano DI FABIO
  • Patent number: 10538479
    Abstract: Subject-matter of the invention is a process for the preparation of key intermediates in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Grant
    Filed: September 28, 2016
    Date of Patent: January 21, 2020
    Assignee: OLON S.P.A.
    Inventors: Corrado Colli, Alessandro Agosti, Stefano Maiorana, Federica Colombo, Giorgio Bertolini
  • Patent number: 10487070
    Abstract: Subject-matter of the invention is a process for preparing intermediates useful in the synthesis of drugs, for example antifungal drugs, such as efinaconazole. Subject-matter of the invention are also such novel synthesis intermediates and the use thereof.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: November 26, 2019
    Assignee: OLSON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Mara Sada, Federica Colombo
  • Publication number: 20190194230
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Application
    Filed: March 21, 2018
    Publication date: June 27, 2019
    Inventors: Federico GASSA, Lazzaro FELICIANI, Alberto MAZZA, Marco QUARONI, Mara SADA, Giorgio BERTOLINI
  • Patent number: 10329311
    Abstract: The present invention relates to a process for the preparation of crisaborole of formula (I): by preparing intermediates of formulas (II) and (III):
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: June 25, 2019
    Assignee: OLON S.P.A.
    Inventors: Federico Gassa, Lazzaro Feliciani, Alberto Mazza, Marco Quaroni, Mara Sada, Giorgio Bertolini
  • Publication number: 20190119244
    Abstract: Subject-matter of the invention is a process for preparing intermediates useful in the synthesis of drugs, for example antifungal drugs, such as efinaconazole. Subject-matter of the invention are also such novel synthesis intermediates and the use thereof.
    Type: Application
    Filed: March 23, 2017
    Publication date: April 25, 2019
    Inventors: Giorgio BERTOLINI, Corrado COLLI, Mara SADA, Federica COLOMBO
  • Publication number: 20180282339
    Abstract: Subject-matter of the invention is a process for the preparation of the amorphous form of ibrutinib and a novel crystalline form.
    Type: Application
    Filed: November 16, 2016
    Publication date: October 4, 2018
    Inventors: Giorgio BERTOLINI, Lazzaro FELICIANI, Ilaria FERRANDO, Mara SADA
  • Publication number: 20180258028
    Abstract: Subject-matter of the invention is a process for the preparation of key intermediates in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Application
    Filed: September 28, 2016
    Publication date: September 13, 2018
    Inventors: Corrado COLLI, Alessandro AGOSTI, Stefano MAIORANA, Federica COLOMBO, Giorgio BERTOLINI
  • Patent number: 10059653
    Abstract: Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Grant
    Filed: January 19, 2016
    Date of Patent: August 28, 2018
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Paolangelo Cerea, Corrado Colli, Lazzaro Feliciani, Federico Gassa, Aldo Bianchi, Federica Colombo, Stefano Maiorana, Filippo Nisic
  • Publication number: 20180222909
    Abstract: Subject-matter of the invention is a process for the preparation of ibrutinib and intermediate compound.
    Type: Application
    Filed: July 27, 2016
    Publication date: August 9, 2018
    Inventors: Giorgio BERTOLINI, Ilaria FERRANDO, Mara SADA
  • Patent number: 10023535
    Abstract: The present invention refers to a process for the preparation of 1-(2-halogen-ethyl)-4-piperidinecarboxylic acid ethyl esters, in particular of 1-(2-chloroethyl)-4 piperidinecarboxylic acid ethyl ester, a versatile synthesis intermediate, particularly useful as an intermediate compound in the synthesis of umeclidinium.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: July 17, 2018
    Assignee: OLON S.P.A.
    Inventors: Giorgio Bertolini, Corrado Colli, Aldo Bianchi, Federica Colombo, Stefano Maiorana, Filippo Nisic
  • Publication number: 20170362161
    Abstract: Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates.
    Type: Application
    Filed: January 19, 2016
    Publication date: December 21, 2017
    Applicant: OLON S.P.A.
    Inventors: Giorgio BERTOLINI, Paolangelo CEREA, Corrado COLLI, Lazzaro FELICIANI, Federico GASSA, Aldo BIANCHI, Federica COLOMBO, Stefano MAIORANA, Filippo NISIC