Abstract: The present disclosure relates to a method of identifying an agent-of-interest that alters binding or activity of a client protein to a chaperone, co-chaperone, or chaperone-co-chaperone complex, the method including: determining a three-dimensional (3D) structure of a client protein-of-interest; evaluating the 3D structure of the client protein-of-interest to identify an unstable substructure of the 3D structure of the client protein-of-interest; and determining an amino acid sequence of the unstable substructure of the 3D structure of the client protein-of-interest to identify an agent-of-interest that alters binding or activity of a client protein to a chaperone, co-chaperone, or chaperone-co-chaperone complex.

Abstract: A two-way rotary joint for fluids is disclosed. An illustrative example of the rotary joint includes a main body provided with two inlet ports, and a rotor rotatably coupled to the main body. The rotor has two passages each in communication with a respective one of the inlet ports in the main body. A ring-shaped hub is rotatably supported relative to the rotor and has a radial outlet port in communication with one of the passages in the rotor.

Abstract: A case (10) for tool accessories, such as drills or jigsaw blades, comprises a base (11) having a closure lid (12) slidable on it. Present in the base are housings (13) for the accessories which are aligned and directed in the sliding direction of the lid. The base (11) has a hinged head end (15) susceptible of being overturned backward on opening of the lid.

Abstract: A blade-holding case for a hack sawing machine comprises a support (13) provided with housings (17) each intended for receiving one end of a blade (18) for supporting it in the case. Each housing (17) has an opening (19) for enabling introduction thereinto of one end of a blade inclined in a first direction (20) towards the fore portion of the housing and enabling rotation of the blade to a supporting position in a second direction (21) angularly spaced apart from the first one towards the rear portion of the housing, so as to insert the blade between lateral-fitting means (22) of the blade when the latter is in the supporting position. The blades can be advantageously inserted in the housings by their toothed fore end.

Abstract: Anti-theft device with extractable armored column for protecting areas in general and for barring doors and the like, having a steel base which has the shape of an at least partially box-like body and which has walls which are at least partially covered with plates of a drill-proof metallic alloy or the like; the base is horizontally buriably in the walking surface and is centrally provided with a through opening; a vertical prism-shaped container made of steel is rigidly applied to the opening, has both longitudinal and transverse reinforcement ridges and is completely embeddable below the walking surface; an armored column is telescopically and removably inserted in the container, is at least partially internally filled with material which has high resistance to abrasion and high hardness and has means for its anchoring to locking means present within the base.