Abstract: This invention relates to a process for the separation of moprolol into its two optical antipodes, substantially characterized by the fact of salifying racemic moprolol with L(+)glutamic acid; treating the thus obtained mixture of diastereoisomeric salts with a water/alcohol mixture, in this way separating the L(+)glutamate insoluble salt of (+)moprolol; treating the resultant mother liquors which contain in solution the L(+)glutamate salt of (-)moprolol with a base so as to separate the laevorotatory isomer of crystalline moprolol, which finally undergoes a purification. The invention also relates to a pharmaceutical composition containing said laevorotatoryisomer of moprolol.

Abstract: Derivatives of aminopyridinecarboxylic acids which inhibit the dipeptidyl carboxy peptidase (DPCP), methods for their preparation and pharmaceutical compositions containing them.The compounds have formula: ##STR1## where Z is hydrogen, alkyl having from 1 to 3 carbon atoms, halogen or alkoxy having from 1 to 3 carbon atoms;R1 is hydrogen, alkyl having from 1 to 6 carbon atoms, arylalkyl having from 7 to 12 carbon atoms, aryl having from 6 to 15 carbon atoms;m and n are an integer of from 0 to 4 each provided, however, the m+n is lower than 5;R2 is hydrogen, alkyl having from 1 to 6 carbon atoms or arylalkyl having from 7 to 12 carbon atoms;R3 is hydrogen or acyl having from 1 to 8 carbon atoms;R4 is hydrogen or alkyl having from 1 to 3 carbon atoms;and their pharmaceutically acceptable salts with organic or inorganic acids.

Abstract: N.sub.1 -acyl-3-amino-1,2,3,4-tetrahydroquinoline compounds active on the cardiocirculatory system, pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the new compounds and some intermediates useful in the preparation of the new tetrahydroquinoline compounds.Process for preparing the new tetrahydroquinoline compounds and some intermediates useful in the preparation thereof.

Abstract: New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.

Abstract: New derivatives of 1,2-ethylenediamine and salts thereof endowed with vascular antispasmodic and antiallergic activity; processes for preparing them, some new intermediates useful in their preparation and pharmaceutical compositions containing them.

Abstract: The magnesium salt of creatinol-O-phosphate, having the formula: ##STR1## is useful in the treatment and in the prevention of the myocardiac infarction.The preparation of the above magnesium salt takes place by reacting creatinol-O-phosphate, as a water solution, with a reactive magnesium compound.The magnesium salt according to the invention may be obtained in either anhydrous or hydrated form and is useful for the preparation of the normal pharmaceutical formulations for the administration by oral and parenteral route.

Abstract: There are disclosed penicillanic and cephalosporanic derivatives of the formula: ##STR1## wherein R is H or --OH; R.sub.1 is a carbohydrate hexose radical of 3-O-glucose, 6-O-galactose, 3-O-glucose acetals, 3-O-glucose ketals, 6-O-galactose acetals, and 6-O-galactose ketals, and R.sub.2 is: ##STR2## where R.sub.3 is H or an alkali or alkaline-earth metal. The preparation of the derivatives and pharmaceutical compositions containing same are also disclosed.A process according to the invention comprises reacting a compound of the formula ##STR3## with a hexose carbohydrate, in --OH protected form, in an aqueous medium, in the presence of a water-miscible organic solvent, in the presence of a base, the reaction product being optionally transformed into the derivative wherein R.sub.1 is a carbohydrate in the unprotected form by treatment with Lewis' acid or a hydrogen halide acid.

Abstract: The present invention relates to a method of inducing a response dopamine-like in an animal having impaired cardiovascular and renal functions, comprising administering to said animal an effective amount of a compound having the general formula: ##STR1## wherein R is a secondary or tertiary alkyl radical having from 3 to 7 carbon atoms, and their salts with nontoxic organic and inorganic acids.In particular, the present invention relates to a method of treating cardiac and renal failures comprising administering to a patient suffering therefrom an effective amount of a compound having the above-identified general formula, in suitable pharmaceutical preparations.

Abstract: Novel derivatives of phenylethylamine, having general formula: ##STR1## wherein R is hydrogen or a lower alkyl, are disclosed, to be used in the therapy of diseases of the digestive apparatus, particularly gastric and/or duodenal ulcers. The novel derivatives of phenylethylamine are prepared(a) from a compound of formula (II) ##STR2## by reaction with potassium cyanate, in the presence of an organic acid; (b) from the compound of formula (II) which is converted to the corresponding phenylcarbonic derivative by reacting with phenylchloroformiate and then with ammonia(c) from a compound of formula (IV) ##STR3## which is converted to a compound of formula (V), the latter being converted to the desired derivatives (I) by treatment with aqueous alkali.

Abstract: The N-m-trifluoromethylphenylanthranilates of O-alcoxycarbonylphenyl, having the formula ##STR1## wherein R is an alkyl group, preferably comprising 1 to 4 carbon atoms, besides being of low toxicity, are endowed with anti-inflammatory properties and are adapted for the treatment of inflammatory and thrombotic diseases. The method for the preparation of the above compounds comprises reacting the N-m-trifluoromethylphenylisatoic anhydride with an alkyl salicylate.

Abstract: Novel ergoline derivatives are disclosed having the general formula (I) ##STR1## wherein R.sub.1 is hydrogen, and alkyl radical (C.sub.1 to C.sub.4) either straight of branched chain,Z is hydrogen, bromine, S-R.sub.IV (in which R.sub.IV is an alkyl of from C.sub.1 to C.sub.4,R.sub.II is equal to R.sub.III and is an alkyl of from C.sub.1 to C.sub.6, orR.sub.II united with R.sub.III by-(CH.sub.2).sub.n, with n from 0 to 7, to form simple heterocyclic compounds such as pyrrolidine, piperidine, hexamethyleneimine, or united with --(CH.sub.2).sub.n --A--(CH.sub.2).sub.n, with n equal to a number from 2 to 5 to form heterocyclic compounds such as A=0 and n=2 to give morpholine, A is N-R.sub.V and N=2 for piperazine, either substituted or unsubstituted, with R.sub.V being hydrogen, an alkyl of from C.sub.1 to C.sub.4, or a phenyl radical, the x--y bridge being a ##STR2## bond. A method for the preparation of such compounds and pharmaceutical compositions thereof are also disclosed.

Abstract: Novel cardiocirculatory analeptics are prepared, which are epinine esters as obtained by reacting epinine (N-methyldopamine) with branched-chain aliphatic carboxylic acids. Exemplary members are 3,4-di-O-butyrylepinine and 3,4-di-O-pivaloylepinine. These medicaments are effective also by the oral route of administration, contrary to the hitherto commonly used dopamine derivatives which are rapidly destroyed by metabolization when administered orally.

Abstract: A number of pharmacologically active ergoline derivatives are disclosed, their preparation is described and examples of suitable pharmaceutical preparations are presented. Of quite particular interest among the rich series of compounds afforded by the present invention are D-2-bromo-1,6-dimethyl-8beta-(perhydroazepinylcarbonyloxymethyl)-ergoline and its salts (especially maleate and methanesulfonate) for the treatment of psychogenetic disorders, and D-2-bromo-6-methyl-8beta-(morpholinocarbonyloxymethyl)-ergoline and its salts (especially the maleate and the methanesulfonate for the treatment of asthma and allied ailments. Good tolerability, low toxicity and high effectiveness distinguish these compounds over those of the prior art.

Abstract: A method is disclosed for extracting lysergol and ergolinic alkaloids from seeds of plants belonging to the Convulvulaceae family, Ipomoeae section, petaloidea genus (Choisy). The process applies to ground and defatted seeds and, after an orderly sequence of extraction, filtrations and crystallization, a first insoluble fraction is obtained, which contains the expected ergoline alkaloids and lysergol, whereafter a second sequence of extractive operations is carried out in order to separate as discrete fractions, the ergolinic alkaloids on the one hand, and the lysergol on the other hand.

Abstract: A method for preparing ergoline derivatives in which the ergoline structure is variously substituted by morpholino-piperazino- and other active radicals to obtain novel compounds useful in cardiology as alpha-blocking, vasodilating, antihypertensive active ingredients of pharmaceutical preparations.

Abstract: A pharmaceutical composition for the therapeutical treatment of anxiety and neurodystonic states characterized by combining an anxiolytic belonging to the class of the benzodiazepines and a beta-adrenergic receptor blocking agent, in which said benzodiazepinic anxiolytic is 3-N,N-dimethylcarbamoyloxy-1-methyl, 5-phenyl, 7-chloro, 1,3-dihydro-2H-1,4-benzodiazepin-2-one- and said beta-adrenergic receptor blocking agent is 1-(0-methoxyphenoxy)-3-isopropylamino-propan-2-olo.

Abstract: Novel sulfamoyl derivatives of 8.beta.-aminomethyl ergoline having the general formula: ##STR1## are disclosed, which have interesting pharmacological properties and are useful as anti-migrainic, anti-hypertensive and psychopharmaceutically active drugs. In the method for their preparation a compound having the formula: ##STR2## is reacted, in an aprotic solvent and at a temperature of between -20.degree. C. and +150.degree. C.

Abstract: Ergoline carbamates are disclosed, which have proven to be effective spasmolytic and vasodilatory drugs. They are derivatives of D-6-methyl-8.beta.-(methanol)-9,10-didehydroergoline (also called lysergol). Three convenient methods for their preparation are also disclosed. The toxicity of these compounds is extremely low.

Abstract: Insect metamorphosis hormones of the polyhydroxylated sterol type are light sensitive and tend to lose their activity under the action of light, especially UV radiations. An insect controlling formulation is suggested herein, which contains, in addition to the insect metamorphosis hormones, photostabilizing substances such as benzotriazoles, substituted phenylglioxylic acids and salts thereof.

Abstract: A process is disclosed for the interconversion of alkaloids of the heteroyohimbane group, more particularly of tetrahydroalstonine into raubasine, having the formulae ##STR1## according to which the asymmetry center at C-20 is inverted by several steps involving changes of the ring E structure.