Patents by Inventor Giorgio Gaudiano

Giorgio Gaudiano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glutathione derivatives of anthracyclines
    Patent number: 5646177
    Abstract: Disclosed herein are new anthracyclines which are derived from conjugation with glutathione, for example from conjugation of adriamycin, daunomycin and menogaril with glutathione: compounds 7 I, 7 II, 8 I, 8 II, 9 I and 9II, are obtained by reduction of the anthracycline followed by reaction of the reduced product with glutathione in aqueous (H.sub.2 O or D.sub.2 O) or organic solvent. The invention also provides salts of these glutathione derivatives, particularly salts formed from anthracycline glutathione anions with anthracycline cations. These anthracycline derivatives are useful as antibiotics, as antitumor agents, and in the treatment of AIDS. These derivatives are particularly useful in the treatment of cancer when multiple drug resistance is present.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: July 8, 1997
    Assignees: Board of Regents of The University of Colorado, Consiglio Nazionale Delle Richerche
    Inventors: Tad H. Koch, Giorgio Gaudiano
  • Oxomorpholinyl dimer and rescue of anthracycline and mitomycin C damage
    Patent number: 4632922
    Abstract: The present invention discloses a bi(3,5-dimethyl-5-hydroxymethyl-2-oxomorpholin-3-yl) compound and its efficacy as a rescue agent against anthracycline and mitomycin C induced tissue damage. A method of synthesizing said compound has also been described.
    Type: Grant
    Filed: October 24, 1985
    Date of Patent: December 30, 1986
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Colorado Foundation, Inc.
    Inventors: Steven D. Averbuch, Nicholas R. Bachur, Giorgio Gaudiano, Tad H. Koch