Abstract: Three-dimensional cell culture device comprising: a container body of cells to be cultivated formed by a first semi-portion and a second semi-portion facing each other and attached together with attachment means; a culture compartment which is defined between the first semi-portion and the second semi-portion; a three-dimensional substrate for the engraftment and/or support of the cells to be cultivated which is located in the culture compartment; an inlet of a transport solution of cells to be cultivated, and an outlet that connects the culture compartment with the outside, to discharge the transport solution; at least one of said first semi-portion and second semi-portion comprises oxygenation means of the cells to be cultivated.

Abstract: The present invention relates to a filtering device (8) for removing substances from blood or a blood component, the filtering device (8) comprising: a housing having an inlet and an outlet, at first sorbent material coupled with at least a first ligand located within the housing, and a second sorbent material coupled with at least a second ligand located within the housing, wherein the first ligand is for removing free hemoglobin (fHb) and the second ligand is for removing microvesicles (MV) from the blood or blood component passing through the filtering device (8), from the inlet to the outlet, wherein the first and second ligand are different from each other, and wherein the first and second sorbent material are the same or are different from each other.

Abstract: The invention relates to a blood filter, a system comprising a blood filter and the use of a blood filter or system for the removal of substances from whole blood or blood components. According to the invention, a blood filter comprises an inlet (2), an outlet (3) and at least first fibers disposed between the inlet (2) and the outlet (3) for filtering a fluid being communicated between the inlet (2) and the outlet (3), wherein each of the first fibers comprises at least one groove extending in the longitudinal direction of the fiber.

Abstract: The present invention relates to a filtering device (8) for removing substances from blood or a blood component, the filtering device (8) comprising: a housing having an inlet and an outlet, at first sorbent material coupled with at least a first ligand located within the housing, and a second sorbent material coupled with at least a second ligand located within the housing, wherein the first ligand is for removing free hemoglobin (fHb) and the second ligand is for removing microvesicles (MV) from the blood or blood component passing through the filtering device (8), from the inlet to the outlet, wherein the first and second ligand are different from each other, and wherein the first and second sorbent material are the same or are different from each other.

Abstract: The invention relates to a blood filter, a system comprising a blood filter and the use of a blood filter or system for the removal of substances from whole blood or blood components. According to the invention, a blood, filter comprises an inlet (2), an outlet (3) and at least first fibres disposed between the inlet (2) and the outlet (3) for filtering a fluid being communicated between the inlet (2) and the outlet (3), wherein each of the first fibres comprises at least one groove extending in the longitudinal direction of the fibre.

Abstract: The invention relates to a filter for the separation of leukocytes from whole blood, comprising a hydrophobic support material and a polymeric coating material, whereby the surface of the filter has a critical surface wetting tension in the range 50 to 80 dyn/cm and the polymeric coating material may be obtained by polymerisation reaction of mixtures comprising hydrophobic and hydrophilic monomers. The invention further relates to a method for production of said filter and devices for the separation of leukocytes from whole blood and the use of the filter.

Abstract: A filter for the removal of substances from blood product has a porous element of a polymeric material consisting of a polyether-ester copolymer or of a polymer blend comprising said copolymer.

Abstract: A filter device for the depletion of the leukocyte content from blood products comprising: a porous element comprising at least one fibrous web having a pore size suitable for leukocyte removal (possibly the range for the pore size should be defined), said web comprising fibres of a hydrophobic polymer coated with a hydrophilic polymer suitable to enhance the CWST of said hydrophobic polymer, characterised in that said web further includes adsorbent particles having a mean diameter lower than 30 ?m, said particles being bonded to said fibres by means of said hydrophilic polymer coating said fibres.

Abstract: A filter device for the depletion of the leukocyte content from blood products comprising: a porous element comprising at least one fibrous web having a pore size suitable for leukocyte removal (possibly the range for the pore size should be defined), said web comprising fibres of a hydrophobic polymer coated with a hydrophilic polymer suitable to enhance the CWST of said hydrophobic polymer, characterised in that said web further includes adsorbent particles having a mean diameter lower than 30 ?m, said particles being bonded to said fibres by means of said hydrophilic polymer coating said fibres.

Abstract: The invention relates to a sterile system and a method for filtering biological or medical liquids, especially blood or blood constituents. According to the filtering system and method, the sterile air already in the system is collected before the beginning of the filtration process, and after the filtration process, in order to completely empty the system used. Said filtering system comprises a collapsible container having a first and second air inlet/outlet line. The first air inlet/outlet line communicates with the first chamber of the filter by means of a flow connection, and the second air inlet/outlet line with the second chamber of the filter. Only the air inlet/outlet line communicating with the first filter chamber is sealed by a hydrophobic membrane or a return valve in the filtering system, such that the system has an especially simple structure.

Abstract: The invention relates to a filter for the separation of leukocytes from whole blood, comprising a hydrophobic support material and a polymeric coating material, whereby the surface of the filter has a critical surface wetting tension in the range 50 to 80 dyn/cm and the polymeric coating material may be obtained by polymerisation reaction of mixtures comprising hydrophobic and hydrophilic monomers. The invention further relates to a method for production of said filter and devices for the separation of leukocytes from whole blood and the use of the filter.

Abstract: A filter device for the depletion of the leukocyte content from blood products including two or more porous elements each made of one or more layers or filtering materials, wherein said porous elements are arranged in the filter device according to decreasing hydrophilicity, from inlet to outlet, of the filtering material constituting said elements.

Abstract: A filter for the removal of substances from blood products A filter for the removal of substances from blood product has a porous element of a polymeric material consisting of a polyether-ester copolymer or of a polymer blend comprising said copolymer.

Abstract: A device for separating blood into blood components comprising:—a collecting container (2) for receiving blood (WB),—a first satellite container (4) connected, in fluid flow communication, to said collecting container (2) through a leukocyte filter (22) for receiving from said collecting container (2) a leukocyte depleted first blood component (PRP),—a second satellite container (6) connected, in fluid flow communication, with said collecting container (2) through said filter (22) for receiving from said collecting container a second leukocyte depleted blood component (PRC), and flow control means (36, 38, 42) for allowing fluid flow from said collecting container selectively into said first (4) or second (6) satellite container through said leukocyte filter (22), whereby whole blood (WB) can be separated into a first (PRP) and second (PRC) leukocyte depleted blood component with a single leukocyte filter (22).

Abstract: The invention relates to a sterile system and a method for filtering biological or medical liquids, especially blood or blood constituents. According to the filtering system and method, the sterile air already in the system is collected before the beginning of the filtration process, and after the filtration process, in order to completely empty the system used. Said filtering system comprises a collapsible container having a first and second air inlet/outlet line. The first air inlet/outlet line communicates with the first chamber of the filter by means of a flow connection, and the second air inlet/outlet line with the second chamber of the filter. Only the air inlet/outlet line communicating with the first filter chamber is sealed by a hydrophobic membrane or a return valve in the filtering system, such that the system has an especially simple structure.

Abstract: The invention relates to a device and a method for separating whole blood into blood components. The device has a collecting container for collecting whole blood, a primary container, and one or a plurality of satellite containers downstream from the primary container. The collecting container is connected to the primary container via a branch line containing a leucocyte filter. In addition, a bypass line is provided between the collecting container and the primary container for creating a fluid connection that circumvents the leucocyte filter. The primary container is also connected, via an additive line, to an additive container containing an additive agent for storing a blood component. The method involves collecting the donor's whole blood in the collecting container and conveying it, via the bypass line, into the primary container. The whole blood located in the primary container is then separated by centrifuigation into an erythrocyte layer and a mixed layer of blood plasma and thrombocytes.

Abstract: A device for separating whole blood into blood components having a collecting container for collecting whole blood, a primary container, and one or a plurality of satellite containers downstream from the primary container. The collecting container is connected to the primary container via a branch line containing a leucocyte filter. In addition, provision is made for a bypass line between the collecting container and the primary container for creating a fluid connection, circumventing the filter. The primary container is, furthermore, connected, via an additive line, to an additive container containing an additive agent for storing a blood component. For extracting leucocyte-free erythrocyte concentrate, the donor's whole blood, collected in the collecting container is first conveyed, via the bypass line into the primary container. The whole blood located in the primary container is then separated by centrifuging into an erythrocyte layer and a mixed layer of blood plasma and thrombocytes.

Abstract: A disposable sterile apparatus (1) for blood filtration with a system for the optimization of blood recovery in the passage from one pouch to the next, having a main tube (4, 8, 13, 18, 19) containing sterile air, one end of which is designed for the connection to a first container (pouch) (2) containing the liquid to be filtered and the other end of which is connected to a second empty container (pouch) (20): The foregoing tube (4, 8, 13, 18, 19) includes at least one filter (12) being arranged in the flow of the liquid. The apparatus (1) contains a tube (7) for the return of air from the second container (20) to the first container (2) acting to equalize pressure of the liquid at the two extremities of the main tube (4, 8, 13, 18, 19) after the liquid has been filtered. The filter (12) features two interior semi-chambers with filtration material separating them. The first semi-chamber has an inlet port while the second semi-chamber has an outlet port and a venting port.

Abstract: A disposable sterile apparatus (1) for blood filtration with a system for the optimization of blood recovery in the passage from one pouch to the next, having a main tube (4, 8, 13, 18, 19) containing sterile air, one end of which is designed for the connection to a first container (pouch) (2) containing the liquid to be filtered and the other end of which is connected to a second empty container (pouch) (20). The foregoing tube (4, 8, 13, 18, 19) includes at least one filter (12) being arranged in the flow of the liquid. The apparatus (1) contains a tube (7) for the return of air from the second (20) to the first container (2) acting to equalize pressure of the liquid at the two extremities of the main tube (4, 8, 13, 18, 19) after the liquid has been filtered. The filter (12) features two interior semi-chambers with filtration material separating them. The first semi-chamber has an inlet port while the second semi-chamber has an outlet port and a venting port.