Abstract: Methods of treatment of colorectal cancer can include the administration of the anti-alpha-v integrin (receptor) antibody Abituzumab. Preferably, the methods of treating colorectal cancer can include treating Stage II-IV colorectal cancer, metastatic colorectal cancer, left-sided colorectal cancer and/or left-sided metastatic colorectal cancer, involving the administration of said Abituzumab to patients in need thereof. Abituzumab is also useful for the manufacture of a medicament for treating colorectal cancer, preferably colorectal cancer as defined herein. Abituzumab is further useful for the manufacture of a medicament for treating colorectal cancer in combination with suitable targeted therapy concepts, such as growth factor or growth factor receptor targeting monoclonal antibodies, and/or chemotherapy.

Abstract: The invention provides a method of treating abnormal cell growth in a mammal, such as a human, by administering to the mammal a therapeutically effective amount of a composition including one or both of 5-(5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)-amide and 5-(5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-ethylaminoethyl)-amide, or pharmaceutically acceptable salts, solvates or hydrates thereof, for at least one cycle of an intermittent dosing regimen.

Abstract: A method of treating a human being suffering from a hormone-dependent disorder characterized by the overexpression of EGFR, comprising administering to said human being an aromatase inhibitor and an EGFR antagonist or EGFR inhibitor, in amounts effective to produce a superadditive or synergistic therapeutic effect.

Abstract: A method of preventing and/or treating estrogen-dependent disorders selected from endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, fibrocystic breast disease and fibrocystic mastopathy, is disclosed which is comprised of administering to a female mammal in need of such treatment an effective amount of aromatase inactivator exemestane, alone or in combination with additional therapeutic agents. The present invention also relates to a method for treating infertility in a female mammal in need of the infertility treatment, comprising administering an effective amount of exemestane to the mammal.

Abstract: The present invention concerns the use of aromatase inhibitor exemestane, either alone or in combination with other therapeutic agents in the chemoprevention of estrogen dependent cancer in mammals, including humans, at increased risk of the disease.

Abstract: A method of treating a human being suffering from an hormone-dependent disorder comprising administering to said human being a steroidal aromatase inhibitor e.g. exemestane of formestane and a non-steroidal aromatase inhibitor e.g. fadrozole or vorozole, in amounts effective to produce a superadditive therapeutic effect.

Abstract: Exemestane is disclosed for use in the first-line treatment of metastatic, advanced hormone-dependent breast cancer, particularly in post-menopausal woman.

Abstract: The invention provides a method of treating gynecomastia in a patient being treated with an antiandrogen, which method comprises administering to a patient in need thereof a therapeutically effective amount of an aromatase inhibitor selected from exemestane, formestane, anastrozole, letrozole and fadrozole, or a pharmaceutical composition comprising a said aromatase inhibitor. The use of a said aromatase inhibitor in the preparation of a pharmaceutical composition for treating gynecomastia induced by antiandrogen therapy and a kit containing the said aromatase inhibitor and an antiandrogen are also provided.