Abstract: A composition provides increased. lithium and selenium content in vegetables and in their bio-technologically and/or technologically processed products. This composition comprises an aqueous solution of lithium compounds and selenium salts having a lithium content ranging from 0.0001 to 15.Og/l and selenium ranging from 0.0001 to 12.Og/l and at least an adjuvant selected among at least alkaline soap, chitosan hydrolysate, chitosan hydrolysate added with lecithin, and tannic acid and/or mixtures thereof where at least an adjuvant is assigned to increase the lithium and selenium ions absorption.

Abstract: Cetylpyridinium salt of diclofenac.

Abstract: Cetylpyridinium salt of diclofenac.

Abstract: A Resveratrol-phospholipid complex, process for the preparation of same and relating highly bioavailable antioxidant and radical blocking pharmaceutical compositions, and cosmetic compositions for the treatment of ageing and cellular degeneration.

Abstract: This invention concerns systems for the release of active principles which are capable of releasing active principle(s) into an aqueous medium at a controlled rate.More precisely, the invention concerns a monolithic system for the controlled release of active principles, consisting of:a) at least one swelling layer containing one or more active principles, in a matrix of swellable, hydrophilic polymers;b) at least one erodible and/or soluble layer comprising excipients and/or water soluble polymers, possibly containing one or more active principles, either the same or different from those present in the layer a), the said erodible and/or soluble layer being in contact with the swelling layer(s) a).

Abstract: The novel compounds 3,6-Disubstituted xanthen-9-one of formula I ##STR1## in which R is a C.sub.3 -C.sub.8 linear, branched or cyclic alkyl and R.sub.1 is linear, branched C.sub.1 -C.sub.8 alkyl or cyclic C.sub.3 -C.sub.8 alkyl or --OR in which R is as defined hereinabove, exhibit bone resorption inhibiting activity. Pharmaceutical compositions are described.

Abstract: The anthocyanidins pelargonidin and delphidin, have been found to possess novel and unexpected activity in the ophthalmic field, specifically that they are active in reducing the permeability of ciliary body vessels. According to one aspect of the present invention there is provided a method of reducing the hyperpermeability of the ciliary body ocular vessels in a subject which comprises administering to the subject an effective dose of pelargonidin or delphidin. The invention further provides the use of pelargonidin or delphidin in the manufacture of pharmaceutical compositions for carrying out the method of treatment referred to above.

Abstract: A class of benzothiazepine esters having structures related to that of diltiazem are provided which possess vasodilating activity while being virtually free of cardiodepressive effects. The esters are useful in the treatment of arterial hypertension and disturbances of the cerebral circulation.The compounds have the general formula I ##STR1## wherein R represents hydrogen or an electronegative group (preferably a halogen atom, or a nitro, trifluoromethyl or methoxy group); andX is a hydrocarbyl group containing from 1 to 15 carbon atoms.

Abstract: Novel water-soluble derivatives of silybin of enhanced activity are provided as well as methods of preparing the derivatives and pharmaceutical compositions containing them. The novel derivatives according to the invention have the following general formula (I); ##STR1## where: R=H or PO(OH).sub.2 and R'=PO(OH).sub.2 The compounds of the invention are useful inter alia in therapy of liver disorders and other applications where an anti-radical effect is required. They have the advantages of high hydrophilicity and are soluble at approximately pH 4, compared to prior art compounds which are water-soluble only at higher pH and enhanced stability.

Abstract: Benzoyoxyacetic acid derivatives of formula (I) ##STR1## wherein M denotes hydrogen or one equivalent of a pharmaceutically acceptable inorganic or organic cation are useful as analgesics and anti-inflammatory agents. A novel process for their preparation is also disclosed along with novel intermediates.

Abstract: The invention relates to novel compounds comprising lipophilic complexes of silybin, silidianin, and silicristin with phospholipids, and the preparation of these complexes by non-conventional methods. Absorption of the novel compounds in the gastrointestinal tract is appreciably greater, resulting in higher plasma levels than for the individual flavanolignans. The resulting improvement in the pharmacokinetic and pharmacological parameters is such that the substances can advantageously be used in the treatment of acute and chronic liver disease of toxic, metabolic or infective origin or of degenerative nature.

Abstract: Preparation of ethyl {6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl}hydrazino carboxylate is disclosed, from 3-chloro-6-hydrazinopyridazine in protected form, which is oxidized to yield the corresponding azo derivative, which is treated with ethyl-(2-hydroxypropyl)amine in the presence of strong bases, the corresponding amino derivative being subjected to reduction and deprotection, and finally acylated to yield ethyl{6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl}hydrazinocarboxylate.

Abstract: Preparation of ethyl {6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl} hydrazino carboxylate is disclosed from 3-chloro-6-hydrazinopyridazine in protected form, which is oxidized to yield the corresponding azo derivative, which is treated with ethyl-(2-hydroxypropyl)amine in the presence of strong bases, the corresponding amino derivative being subjected to reduction and deprotection, and finally acylated to yield ethyl {6-[ethyl-(2-hydroxypropyl)amino]-3-pyridazinyl} hydrazinocarboxylate.

Abstract: There are described a new pharmaceutically active derivative of ursolic acid, 3.beta.-(3-carboxypropionyloxy)ursa-9(11),12-dien-28-oic acid, which possesses activity as an anti-ulcer and anti-viral agent, pharmaceutically acceptable, non-toxic salts thereof, a method of preparing the same and compositions containing the same.

Abstract: Formyl derivatives of hydrazinopenicillins of the formula ##STR1## wherein R is thienyl or phenyl, R' is hydrogen, formyl or alkyl containing from 1 to 3 carbon atoms and R" is hydrogen or formyl, provided that at least one of R' and R" is a formyl group, the carbon atom with the asterisk indicating a center of asymmetry of the molecule, and pharmaceutically acceptable salts and esters thereof, as mixture or as separated epimers. These compounds have antibacterial activity against Gram-negative and Gram-positive bacteria and are prepared by a process wherein the corresponding hydrazinopenicillin is reacted under anhydrous conditions with acetoformic anhydride to give the desired compounds.

Abstract: There are described new alkoxyalkylidenhydrazinopyridazines having antihypertensive activity having the formula: ##STR1## wherein R is alkyl or cycloalkyl having up to 5 carbon atoms, optionally substituted with unsubstituted phenyl, substituted phenyl or cycloalkyl, R.sub.1 is hydrogen or alkyl having 1 to 3 carbon atoms and R.sub.2 is alkyl having 1 to 3 carbon atoms, a carboxylic group or phenyl and the process for their preparation.

Abstract: Hydrazono penicillin derivatives of the formula ##STR1## wherein R represents phenyl optionally substituted, 2- or 3- thienyl optionally substituted, or 2- or 3-furyl optionally substituted, R.sub.1 represents hydrogen, alkyl containing from 1 to 4 carbon atoms, or phenyl, and R.sub.2 represents hydrogen, pivaloyloxymethyl, or 1-(ethoxycarbonyloxy)ethyl radical. The compounds have antibacterial activity against gram-negative and gram-positive microorganisms. Methods of preparation are also disclosed.

Abstract: Hydrazono derivatives of cephalosporins of the formula ##STR1## wherein R is phenyl optionally substituted, 2- or 3-thienyl optionally substituted, or 2- or 3-furyl optionally substituted, R.sub.1 is hydrogen or alkyl having from 1 to 4 carbon atoms, and R.sub.2 is hydrogen, acetoxy, carbamoyloxy or a heterocyclic nucleus preferably bounded through a sulphur atom to the methylene group. The compounds have bactericidal activity. Methods of preparation are also disclosed.

Abstract: Preparation of compounds of the formula: ##STR1## wherein n is 1, 2 or 3, R.sub.1 and R.sub.2, which may be the same or different, are hydrogen or alkyl containing 1 to 3 carbon atoms and the asterisk indicates the center of asymmetry of the molecule, and compounds of the formula ##STR2## wherein R" is a saturated or unsaturated aliphatic hydrocarbon containing 1 to 6 carbon atoms, R.sub.3 is hydrogen or acyl containing 1 to 7 carbon atoms and the asterisk indicates the center of asymmetry of the molecule. The compounds produced by the present invention improve learning memory and display a protecting effect against the E.E.G. consequence of an overdose of barbiturates and against the reduced performance following brain damage (e.g. cerebral edema).

Abstract: 3.beta.-Hydroxy-18.beta.-olean-9-en-30-oic acids having anti-ulcer activity of the formula ##STR1## compositions containing the same and process for their preparation.