Patents by Inventor Giorgio Sagramora

Giorgio Sagramora has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Resolution process of intermediates useful for the preparation of diltiazem
    Patent number: 5097059
    Abstract: A process of spontaneous resolution of compounds of formula ##STR1## wherein R has the meanings reported in the description, is described. The compounds of formula III are intermediates useful for the preparation of Diltiazem.
    Type: Grant
    Filed: July 26, 1990
    Date of Patent: March 17, 1992
    Assignee: Zambon Group S.p.A.
    Inventors: Claudio Giordano, Dario Tentorio, Roberto Casagrande, Placido Bertin, Valeriano Merli, Giorgio Sagramora
  • Process for the preparation of intermediates for the synthesis of diltiazem
    Patent number: 4939295
    Abstract: A process for the preparation of (2S,3S)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)-propioni c acid by resolution of the racemic mixture is described.The resolution is carried out by using as resolving agent (1S,2S)-threo-1-phenyl-2-amino-1,3-propanediol or (1S,2S)-threo-1-(4-methylthiophenyl)-2-amino-1,3-propanediol.
    Type: Grant
    Filed: July 25, 1989
    Date of Patent: July 3, 1990
    Assignee: Zambon Group S.p.A.
    Inventors: Valeriano Merli, Giorgio Sagramora, Giorgio Soriato
  • Process for the preparation of basic esters of substituted hydroxycyclohexanecarboxylic acids
    Patent number: 4336398
    Abstract: The yield of compounds having the general formula: ##EQU1## wherein R represents ##STR1## in the process comprising reacting a substituted hydroxycyclohexanecarboxylic acid with an aminoisopropyl chloride, is highly improved by heating the reaction mixture to 160.degree. to 240.degree. C. for at least 3 hours, and distilling under reduced pressure the resulting product. Thus the content of the undesired isomer is reduced to less than 1-1.5%.
    Type: Grant
    Filed: November 23, 1979
    Date of Patent: June 22, 1982
    Assignee: Laboratorio Guidotti & C. S.p.A.
    Inventor: Giorgio Sagramora