Patents by Inventor Giovanni Battista Giovenzana
Giovanni Battista Giovenzana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220098170Abstract: Disclosed is a process for the synthesis of gepirone of formula (I) from 8-(pyrimidin-2-yl)-5,8-diazaspiro[4,5]decan-5-ium bromide. The process according to the invention is economically efficient and easily industrially scalable.Type: ApplicationFiled: January 13, 2020Publication date: March 31, 2022Applicant: Procos S.P.A.Inventors: Giampiero Colombano, Mauro Barbero, Giovanni Battista Giovenzana, Jacopo Roletto, Paolo Paissoni
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Patent number: 11021451Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: June 30, 2020Date of Patent: June 1, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
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Patent number: 11007283Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: April 5, 2017Date of Patent: May 18, 2021Assignee: BRACCO IMAGING S.P.A.Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
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Publication number: 20200325108Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: ApplicationFiled: June 30, 2020Publication date: October 15, 2020Applicant: BRACCO IMAGING S.P.A.Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
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Patent number: 10793533Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: December 11, 2017Date of Patent: October 6, 2020Assignee: BRACCO IMAGING S.P.A.Inventors: Valeria Boi, Roberta Napolitano, Luciano Lattuada, Giovanni Battista Giovenzana
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Patent number: 10781188Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: GrantFiled: December 12, 2016Date of Patent: September 22, 2020Assignee: BRACCO IMAGING S.P.A.Inventors: Luciano Lattuada, Roberta Napolitano, Valeria Boi, Massimo Visigalli, Silvio Aime, Giovanni Battista Giovenzana, Alberto Fringuello Mingo
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Publication number: 20200017453Abstract: The present invention relates to new class of dimeric macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with the paramagnetic metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: ApplicationFiled: December 11, 2017Publication date: January 16, 2020Applicant: BRACCO IMAGING S.P.A.Inventors: Valeria BOI, Roberta NAPOLITANO, Luciano LATTUADA, Giovanni Battista GIOVENZANA
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Publication number: 20190167819Abstract: The present invention relates to new class of functionalized polyazamacrocycles including at least one phosphonic or phosphinic group linked to a nitrogen atom of the macrocyclic cage, and capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: ApplicationFiled: April 5, 2017Publication date: June 6, 2019Applicant: BRACCO IMAGING S.P.A.Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
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Publication number: 20180362476Abstract: The present invention relates to new class of functionalized macrocycles capable of chelating paramagnetic metal ions, their chelated complexes with metal ions and the use thereof as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis.Type: ApplicationFiled: December 12, 2016Publication date: December 20, 2018Applicant: BRACCO IMAGING S.P.A.Inventors: Luciano LATTUADA, Roberta NAPOLITANO, Valeria BOI, Massimo VISIGALLI, Silvio AIME, Giovanni Battista GIOVENZANA, Alberto FRINGUELLO MINGO
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Patent number: 9694090Abstract: The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.Type: GrantFiled: April 8, 2011Date of Patent: July 4, 2017Assignee: BRACCO IMAGING S.P.A.Inventors: Silvio Aime, Giovanni Battista Giovenzana, Fabio Tedoldi, Alessandro Maiocchi, Fulvio Uggeri, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Massimo Visigalli, Marco Crosetti, Luisa Poggi
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Patent number: 9511154Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.Type: GrantFiled: October 11, 2012Date of Patent: December 6, 2016Assignee: BRACCO IMAGING S.P.A.Inventors: Silvio Aime, Sonia Colombo Serra, Giovanni Battista Giovenzana, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi
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Patent number: 9193659Abstract: The present invention relates to a process for the preparation of iodinated phenols, —in particular, it relates to a process including the electrochemical iodination of 3,5-disubstituted phenols of formula (1) to the corresponding 3,5-disubstituted-2, 4,6-triiodophenols of formula (2), which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. Furthermore, the present invention includes the electrochemical iodination of 3, 5- disubstituted anilines of formula (6) to the corresponding 3,5-disubstituted-2,4,6-triiodoanilins of formula (7).Type: GrantFiled: February 16, 2009Date of Patent: November 24, 2015Assignee: BRACCO IMAGING S.P.A.Inventors: Giovanni Battista Giovenzana, Camilla Cavallotti, Luciano Lattuada, Fulvio Uggeri
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Patent number: 9157156Abstract: The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.Type: GrantFiled: July 6, 2010Date of Patent: October 13, 2015Assignee: Bracco Imaging S.P.A.Inventors: Pier Lucio Anelli, Carlo Felice Viscardi, Pietro Delogu, Fabrizio Goffredi, Alfonso Nardelli, Giovanni Battista Giovenzana
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Patent number: 8961933Abstract: The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from the crude solution by means of a fast phase-transfer extraction and isolated in an impurity-free aqueous solution, ready for use in the MRI diagnostic imaging of organs, region or tissues of the human or animal body.Type: GrantFiled: September 30, 2009Date of Patent: February 24, 2015Assignee: Bracco Imaging S.p.A.Inventors: Francesca Reineri, Alessandra Viale, Giovanni Battista Giovenzana, Daniela Santelia, Walter Dastru′, Roberto Gobetto, Silvio Aime, Fulvio Uggeri
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Patent number: 8945512Abstract: Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).Type: GrantFiled: April 6, 2004Date of Patent: February 3, 2015Assignee: Bracco Imaging SpAInventors: Silvio Aime, Enzo Terreno, Daniela Delli Castelli, Giovanni Battista Giovenzana
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Publication number: 20140257085Abstract: The present invention relates to a process for the preparation of aqueous solutions of hyperpolarized carboxylic organic acids ready for use in in-vivo MR diagnostic imaging, and the use of the corresponding anhydrides or esters as glass-forming agents.Type: ApplicationFiled: October 11, 2012Publication date: September 11, 2014Applicant: BRACCO IMAGING S.P.A.Inventors: Silvio Aime, Sonia Colombo Serra, Giovanni Battista Giovenzana, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Fabio Tedoldi
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Publication number: 20130096420Abstract: The present invention generally relates to a process for the preparation of aqueous solutions of hyperpolarized molecules ready for use in in-vivo MR diagnostic imaging, the use thereof as MRI contrast agent in investigation methods for producing diagnostic MR images of a human or non-human animal body organ, region or tissue.Type: ApplicationFiled: April 8, 2011Publication date: April 18, 2013Applicant: BRACCO IMAGING S.P.A.Inventors: Silvio Aime, Giovanni Battista Giovenzana, Fabio Tedoldi, Alessandro Maiocchi, Fulvio Uggeri, Pernille Rose Jensen, Magnus Karlsson, Mathilde H. Lerche, Massimo Visigalli, Marco Crosetti, Luisa Poggi
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Publication number: 20120088926Abstract: The present invention describes a process for the synthesis of a iodinating agent, being said iodinating agent iodine chloride (ICI.) In particular, the present invention relates to a process for the electrochemical preparation of ICI, as a useful iodinating agent in the preparation of iodinated organic compounds for use as contrast agents or their precursors in the synthesis of the same.Type: ApplicationFiled: July 6, 2010Publication date: April 12, 2012Applicant: BRACCO IMAGING S.P.A.Inventors: Pier Lucio Anelli, Carlo Felice Viscardi, Pietro Delogu, Fabrizio Goffredi, Alfonso Nardelli, Giovanni Battista Giovenzana
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Publication number: 20110082280Abstract: Methods of coupling targeting molecules to multidentate aza ligands of general formula (I): in which: R1 through R5 and FG are as defined in the specification are presented. The aza ligands and/or the resulting conjugates may be labeled with bi-trivalent ions of the metal elements having atomic number ranging between 20 and 31, 39, 42, 43, 44, 49, and between 57 and 83, and radioisotopes chosen among 203Pb, 67Ga, 68Ga, 72As, 111In, 113In, 90Y, 97Ru, 62Cu, 64Cu, 52Fe, 52mMn, 140La, 175Yb, 153Sm, 166Ho, 149Pm, 177Lu, 142Pr, 159Gd, 212Bi, 47Sc, 149Pm, 67Cu, 111Ag, 199Au, 161Tb, 51Cr, 167Tm, 141Ce, 168Yb, 88Y, 165Dy, 166Dy, 97Ru, 103Ru, 186Re, 188Re, 99mTc, 211Bi, 212Bi, 213Bi, 214Bi, 105Rh, 109Pd, 117mSn, 177Sn and 199Au.Type: ApplicationFiled: November 18, 2010Publication date: April 7, 2011Applicant: BRACCO IMAGING S.P.A.Inventors: Giovanni Battista GIOVENZANA, Giovanni PALMISANO, Massimo SISTI, Camilla CAVALLOTTI, Silvio AIME, Luisella CALABI, Rolf SWENSON, Kondareddiar RAMALINGAM, Luciano LATTUADA, Pierfrancesco MOROSINI
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Patent number: 7893223Abstract: Compounds of general formula (I): with substituents as defined herein and their chelates with bi-trivalent ions of the metal elements of atomic numbers 20 to 31, 39, 42, 43, 44, 49, and 57 to 83, and radioisotopes chosen among 203Pb, 67Ga, 68Ga, 72As, 111In, 113In, 90Y, 97Ru, 62Cu, 64Cu, 52Fe, 52mMn, 140La, 175Yb, 153Sm, 166Ho, 149Pm, 177Lu, 142Pr, 159Gd, 212Bi, 47Sc, 149Pm, 67Cu, 111Ag, 199Au, 161Tb, 51Cr, 167Tm, 141Ce, 168Yb, 88Y, 165Dy, 166Dy, 97Ru, 103Ru, 186Re, 99mTc, 211Bi, 213Bi, 214Bi, 105Rh, 109Pd, 177mSn, 177Sn and 199Au, as well as the salts thereof with physiologically compatible bases or acids.Type: GrantFiled: June 24, 2005Date of Patent: February 22, 2011Assignee: Bracco Imaging S.p.A.Inventors: Giovanni Battista Giovenzana, Giovanni Palmisano, Massimo Sisti, Camilla Cavallotti, Silvio Aime, Luisella Calabi, Rolf Swenson, Ramalingam Kondareddiar, Luciano Lattuada, Pierfrancesco Morosini