Abstract: The present invention relates to novel Helicobacter felis urease subunit polypeptides and to nucleic acid sequences encoding these subunit polypeptides, to DNA fragments and recombinant DNA molecules comprising the nucleic acid sequences encoding these subunit polypeptides, to live recombinant carriers and to host cells comprising nucleic acid sequences encoding these subunit polypeptides. Also, the invention relates to the subunit polypeptides for use in vaccines and the use in the manufacturing thereof, to vaccines comprising said subunit polypeptides and to methods for the preparation of such vaccines. Furthermore, the invention relates to diagnostic methods for the detection of Helicobacter felis specific nucleic acid sequences, Helicobacter felis antigenic material and to antibodies against Helicobacter felis.

Abstract: Within the prophylaxis strategies for the control of type A avian influenza caused by viral infection with specific epidemic strain H7N1, a vaccination process is envisaged comprising the preparation of a heterologous vaccine that is administered to an animal population, said vaccine featuring the same subtype of viral haemoagglutinin HA7 and a different subtype of neuroaminidase NA3, and thereafter detecting the viralinfection positiveness by contacting an antigen with at least one genomic sequence that codes for a neuroaminidase NA1 protein with the biological fluids collected from the animals By subsequently revealing an antigen-anti-body reaction by means of a test for detecting positiveness (iIFA, ELISA among others), the vaccinated animals can be discriminated from the other ones. The recombinant antigen is represented by the recombinant glycoprotein neuroaminidase NA1, the genomic sequence of which is carried by a baculovirus and expressed in insect cell.

Abstract: The present invention relates to novel Helicobacter felis urease subunit polypeptides and to nucleic acid sequences encoding these subunit polypeptides, to DNA fragments and recombinant DNA molecules comprising the nucleic acid sequences encoding these subunit polypeptides, to live recombinant carriers and to host cells comprising nucleic acid sequences encoding these subunit polypeptides. Also, the invention relates to the subunit polypeptides for use in vaccines and the use in the manufacturing thereof, to vaccines comprising said subunit polypeptides and to methods for the preparation of such vaccines. Furthermore, the invention relates to diagnostic methods for the detection of Helicobacter felis specific nucleic acid sequences, Helicobacter felis antigenic material and to antibodies against Helicobacter felis.