Patents by Inventor Giovanni Coppola

Giovanni Coppola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF SMOKING WITH CHOLINERGIC RECEPTOR NICOTINIC BETA 3 SUBUNIT (CHRNB3) INHIBITORS
    Publication number: 20250136996
    Abstract: The present disclosure provides methods of treating subjects having a smoking addiction/disorder, and methods of identifying subjects having an increased risk of developing a smoking addiction/disorder.
    Type: Application
    Filed: August 19, 2024
    Publication date: May 1, 2025
    Inventors: Veera Rajagopal, Giovanni Coppola, Aris Baras, Jonathan Marchini, Andrey Ziyatdinov, Mohsin Ahmed, Olivier Harari
  • Treatment Of Macular Degeneration With Complement Factor D (CFD) Inhibitors
    Publication number: 20250129371
    Abstract: The present disclosure generally relates to the treatment of subjects having macular degeneration or at risk of developing macular degeneration by administering a Complement Factor D (CFD) inhibitor to the subject, and to methods of identifying subjects having an increased risk of developing macular degeneration.
    Type: Application
    Filed: October 10, 2024
    Publication date: April 24, 2025
    Inventors: Neelroop Parikshak, Eric Jorgenson, Xinyuan Zhang, Giovanni Coppola, Goncalo Abecasis, Aris Baras, Botir Sagdullaev, Ying Hu, Kevin Kanning, Aarin Jones, Huy Vu
  • Treatment Of Uveitis With Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Inhibitors
    Publication number: 20250115918
    Abstract: The present disclosure provides methods of treating subjects having uveitis, and methods of identifying subjects having an increased risk of developing uveitis.
    Type: Application
    Filed: October 24, 2024
    Publication date: April 10, 2025
    Inventors: Sahar Gelfman, Ann Ligocki, Giovanni Coppola, Aris Baras, Arden Moscati, Eli A. Stahl, Carmelo Romano, Santiago Mendez Huergo, Jonathan Weyne, Tave Van Zyl
  • Kelch domain containing 7B (KLHDC7B) variants and uses thereof
    Patent number: 12258627
    Abstract: The present disclosure provides methods of treating subjects having hearing loss, methods of identifying subjects having an increased risk of developing hearing loss, and methods of detecting Kelch Domain Containing 7B (KLHDC7B) variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: April 19, 2023
    Date of Patent: March 25, 2025
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis
  • Treatment of uveitis with endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitors
    Patent number: 12157891
    Abstract: The present disclosure provides methods of treating subjects having uveitis, and methods of identifying subjects having an increased risk of developing uveitis.
    Type: Grant
    Filed: October 13, 2022
    Date of Patent: December 3, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Sahar Gelfman, Ann Ligocki, Giovanni Coppola, Aris Baras, Arden Moscati, Eli A. Stahl, Carmelo Romano, Santiago Mendez Huergo, Jonathan Weyne, Tave Van Zyl
  • Treatment Of Stroke With 1,4-Alpha-Glucan-Branching Enzyme (GBE1) Inhibitors
    Publication number: 20240247267
    Abstract: The present disclosure generally relates to the treatment of subjects having a stroke or at risk of developing a stroke by administering a 1,4-alpha-glucan-branching enzyme (GBE1) inhibitor to the subject.
    Type: Application
    Filed: January 24, 2024
    Publication date: July 25, 2024
    Inventors: Neelroop Parikshak, Giovanni Coppola, Jonathan Marchini, Benjamin Geraghty, Sahar Gelfman, Tanima De, Veera Rajagopal, Ernst Mayerhofer, Nilanjana Banerjee
  • Treatment Of B27-Negative Uveitis With Inositol Polyphosphate Multikinase (IPMK) Therapeutic Agents Or Indoleamine 2,3-dioxygenase 2 (IDO2) Agonists
    Publication number: 20240238384
    Abstract: Methods of treating B27-negative subjects having uveitis with an Inositol Polyphosphate Multikinase (IPMK) therapeutic agent and/or an Indoleamine 2,3-dioxygenase 2 (IDO2) agonist, and methods of identifying subjects having an increased risk of developing uveitis are described herein.
    Type: Application
    Filed: January 16, 2024
    Publication date: July 18, 2024
    Inventors: Sahar Gelfman, Arden Moscati, Aris Baras, Eli A. Stahl, Giovanni Coppola, Ann Ligocki, Carmelo Romano, Santiago Mendez Huergo, Jonathan Weyne, Tave Van Zyl, Rujin Wang, Charles Miller
  • Treatment Of Prion Diseases
    Publication number: 20240189456
    Abstract: Methods of treating subjects having a prion disease or at risk of developing a prion disease by administering a nucleic acid molecule encoding a modified Prion protein (PrP), and methods of identifying a subject that is a candidate for treatment or prevention of a prion disease are presented herein.
    Type: Application
    Filed: December 11, 2023
    Publication date: June 13, 2024
    Inventors: Sahar Gelfman, Andreja Avbersek, Sarah Wolf, Alicia Hawes, Giovanni Coppola, Vijay Kumar Manickavasagam Pounraja
  • Treatment Of Inflammation With Glucocorticoids And Angiopoietin-Like 7 (ANGPTL7) Inhibitors
    Publication number: 20240148774
    Abstract: The present disclosure provides methods of treating subjects having inflammation with an Angiopoietin-Like 7 (ANGPTL7) inhibitor and a glucocorticoid, methods of decreasing glucocorticoid-induced ophthalmic conditions in subjects, and methods of identifying subjects having an increased risk of developing glucocorticoid-induced ophthalmic conditions.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 9, 2024
    Inventors: Gaurang Patel, Ying Hu, Kavita Praveen, Giovanni Coppola, Goncalo Abecasis, Aris Baras, Carmelo Romano
  • Treatment Of Ophthalmic Conditions With Son of Sevenless 2 (SOS2) Inhibitors
    Publication number: 20240102013
    Abstract: The present disclosure provides methods of treating patients having an ophthalmic condition, methods of identifying subjects having an increased risk of developing an ophthalmic condition, methods of detecting human Son of Sevenless 2 (SOS2) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: October 12, 2023
    Publication date: March 28, 2024
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Goncalo Abecasis, Aris Baras
  • Treatment of inflammation with glucocorticoids and angiopoietin-like 7 (ANGPTL7) inhibitors
    Patent number: 11865134
    Abstract: The present disclosure provides methods of treating subjects having inflammation with an Angiopoietin-Like 7 (ANGPTL7) inhibitor and a glucocorticoid, methods of decreasing glucocorticoid-induced ophthalmic conditions in subjects, and methods of identifying subjects having an increased risk of developing glucocorticoid-induced ophthalmic conditions.
    Type: Grant
    Filed: February 23, 2022
    Date of Patent: January 9, 2024
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Gaurang Patel, Ying Hu, Kavita Praveen, Giovanni Coppola, Goncalo Abecasis, Aris Baras, Carmelo Romano
  • Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
    Patent number: 11845989
    Abstract: The present disclosure provides methods of treating patients having an ophthalmic condition, methods of identifying subjects having an increased risk of developing an ophthalmic condition, methods of detecting human angiopoietin like 7 (ANGPTL7) variant nucleic acid molecules and variant polypeptides, and ANGPTL7 variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: December 19, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kavita Praveen, Claudia Schurmann, Lauren Gurski, Tanya Teslovich Dostal, Goncalo Abecasis, Aris Baras, Giovanni Coppola, Gaurang Patel, Ying Hu, Carmelo Romano, Giusy Della Gatta, Trikaldarshi Persaud
  • Treatment of ophthalmic conditions with son of Sevenless 2 (SOS2) inhibitors
    Patent number: 11820982
    Abstract: The present disclosure provides methods of treating patients having an ophthalmic condition, methods of identifying subjects having an increased risk of developing an ophthalmic condition, methods of detecting human Son of Sevenless 2 (SOS2) variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: November 21, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Goncalo Abecasis, Aris Baras
  • Kelch Domain Containing 7B (KLHDC7B) Variants And Uses Thereof
    Publication number: 20230366024
    Abstract: The present disclosure provides methods of treating subjects having hearing loss, methods of identifying subjects having an increased risk of developing hearing loss, and methods of detecting Kelch Domain Containing 7B (KLHDC7B) variant nucleic acid molecules and variant polypeptides.
    Type: Application
    Filed: April 19, 2023
    Publication date: November 16, 2023
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis
  • Treatment of ophthalmic conditions with angiopoietin-like 7 (ANGPTL7) inhibitors
    Patent number: 11767526
    Abstract: The present disclosure provides methods of treating patients having an ophthalmic condition, methods of identifying subjects having an increased risk of developing an ophthalmic condition, methods of detecting human angiopoietin like 7 (ANGPTL7) variant nucleic acid molecules and variant polypeptides, and ANGPTL7 variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: September 26, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kavita Praveen, Claudia Schurmann, Lauren Gurski, Tanya Teslovich Dostal, Goncalo Abecasis, Aris Baras, Giovanni Coppola, Carmelo Romano
  • Triggering Receptor Expressed On Myeloid Cells 2 (TREM2) Variants And Uses Thereof
    Publication number: 20230287422
    Abstract: The present disclosure provides methods of treating subjects having Alzheimer's Disease, and methods of identifying subjects having an increased risk of developing Alzheimer's Disease.
    Type: Application
    Filed: January 10, 2023
    Publication date: September 14, 2023
    Inventors: Jan Freudenberg, Giovanni Coppola, Katherine Siminovitch
  • Methods Of Treating Headaches And Migraines With Sodium Voltage-Gated Channel Alpha Subunit 11 (SCN11A) Inhibitors
    Publication number: 20230279400
    Abstract: The present disclosure provides methods of treating a subject having a headache or a migraine or preventing a subject from developing a headache or a migraine by administering an Sodium Voltage-Gated Channel Alpha Subunit 11 (SCN11A) inhibitor, and methods of identifying subjects having an increased risk of developing a headache or a migraine.
    Type: Application
    Filed: November 21, 2022
    Publication date: September 7, 2023
    Inventors: Kavita Praveen, Giovanni Coppola, Aris Baras
  • Treatment Of Uveitis With Endoplasmic Reticulum Aminopeptidase 1 (ERAP1) Inhibitors
    Publication number: 20230250434
    Abstract: The present disclosure provides methods of treating subjects having uveitis, and methods of identifying subjects having an increased risk of developing uveitis.
    Type: Application
    Filed: October 13, 2022
    Publication date: August 10, 2023
    Inventors: Sahar Gelfman, Ann Ligocki, Giovanni Coppola, Aris Baras, Arden Moscati, Eli A. Stahl, Carmelo Romano, Santiago Mendez Huergo, Jonathan Weyne, Tave Van Zyl
  • Kelch domain containing 7B (KLHDC7B) variants and uses thereof
    Patent number: 11674177
    Abstract: The present disclosure provides methods of treating subjects having hearing loss, methods of identifying subjects having an increased risk of developing hearing loss, and methods of detecting Kelch Domain Containing 7B (KLHDC7B) variant nucleic acid molecules and variant polypeptides.
    Type: Grant
    Filed: May 4, 2021
    Date of Patent: June 13, 2023
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Kavita Praveen, Giovanni Coppola, Manuel Allen Revez Ferreira, Lauren Gurski, Aris Baras, Meghan Drummond Samuelson, Goncalo Abecasis
  • Treatment Of Psychiatric Disorders And Psychiatric Disorder-Associated MRI Phenotypes With Stabilin 1 (STAB1) Inhibitors
    Publication number: 20230108957
    Abstract: The present disclosure provides methods of treating subjects having psychiatric disorders and/or psychiatric disorder-associated MRI phenotypes, and methods of identifying subjects having an increased risk of developing psychiatric disorders and/or psychiatric disorder-associated MRI phenotypes.
    Type: Application
    Filed: September 29, 2022
    Publication date: April 6, 2023
    Inventors: Manuel Allen Revez Ferreira, Veera Rajagopal, Giovanni Coppola, Jonathan Marchini, Aris Baras