Patents by Inventor Giovanni Fogliato
Giovanni Fogliato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11278622Abstract: This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.Type: GrantFiled: September 18, 2019Date of Patent: March 22, 2022Assignee: Merck Sharp & Dohme Corp.Inventors: Joseph Terracciano, Nicole Miller Damour, Chun Jiang, Giovanni Fogliato, Giuseppe Alessandron Donadelli, Dario Resemini
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Patent number: 10941161Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.Type: GrantFiled: March 4, 2019Date of Patent: March 9, 2021Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Publication number: 20200009251Abstract: This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.Type: ApplicationFiled: September 18, 2019Publication date: January 9, 2020Applicant: Merck Sharp & Dohme Corp.Inventors: Joseph TERRACCIANO, Nicole Miller DAMOUR, Chun JIANG, Giovanni FOGLIATO, Giuseppe Alessandron DONADELLI, Dario RESEMINI
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Patent number: 10420841Abstract: This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.Type: GrantFiled: December 18, 2017Date of Patent: September 24, 2019Assignee: Merck, Sharp & Dohme Corp.Inventors: Joseph Terracciano, Nicole Miller Damour, Chun Jiang, Giovanni Fogliato, Giuseppe Alessandron Donadelli, Dario Resemini
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Publication number: 20190225624Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates of TATD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane.Type: ApplicationFiled: March 4, 2019Publication date: July 25, 2019Applicant: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Patent number: 10221196Abstract: Described herein are crystalline forms of a compound of formula (II?), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (II?): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.Type: GrantFiled: August 14, 2015Date of Patent: March 5, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Patent number: 10214543Abstract: Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.Type: GrantFiled: December 18, 2015Date of Patent: February 26, 2019Assignee: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, Michele Benotti
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Publication number: 20180169106Abstract: Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane prepared in the absence of tazobactam, tazobactam prepared in the absence of ceftolozane, and/or compositions where ceftolozane and tazobactam are first combined within a unit dosage form container.Type: ApplicationFiled: February 13, 2018Publication date: June 21, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Joseph TERRACCIANO, Nicole Miller DAMOUR, Chun JIANG, Giovanni FOGLIATO, Giuseppe Alessandro DONADELLI, DARIO RESEMINI
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Publication number: 20180170949Abstract: Described herein are methods for the manufacture of ceftolozane and related compounds, as well as compositions comprising the same.Type: ApplicationFiled: December 18, 2015Publication date: June 21, 2018Applicant: MERCK SHARP & DOHME CORP.Inventors: Kristos Adrian MOSHOS, Valdas JURKAUSKAS, Giovanni FOGLIATO, Manuel SCANU, Michele BENOTTI
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Patent number: 9963465Abstract: A method of forming a compound of formula (IIIa): wherein: R1 in each occurrence is independently selected from H, halogen, amino, C1-5 alkyl, C1-5 alkenyl and C1-5 alkynyl; R2 in each occurrence is independently selected from H, halogen, amino, C1-5 alkyl, C1-5 alkenyl and C1-5 alkynyl; R4 is C1-5 alkyl; and R6 is a C1-5 fluoroalkyl; and PG is a protecting group, the method comprising the step of reacting a compound of formula (IIa) with a compound of formula (VIII):Type: GrantFiled: May 14, 2015Date of Patent: May 8, 2018Assignee: Allecra Therapeutics SASInventors: Andrea Faini, Marco Forzatti, Giovanni Fogliato, Stefano Biondi
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Publication number: 20180104338Abstract: This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.Type: ApplicationFiled: December 18, 2017Publication date: April 19, 2018Applicant: Merck Sharp & Dohme Corp.Inventors: Joseph TERRACCIANO, Nicole Miller DAMOUR, Chun JIANG, Giovanni FOGLIATO, Giuseppe Alessandron DONADELLI, Dario RESEMINI
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Patent number: 9925196Abstract: Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane prepared in the absence of tazobactam, tazobactam prepared in the absence of ceftolozane, and/or compositions where ceftolozane and tazobactam are first combined within a unit dosage form container.Type: GrantFiled: March 16, 2016Date of Patent: March 27, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Joseph Terracciano, Nicole Miller Damour, Chun Jiang, Giovanni Fogliato, Giuseppe Alessandro Donadelli, Dario Resemini
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Patent number: 9872906Abstract: This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.Type: GrantFiled: September 16, 2015Date of Patent: January 23, 2018Assignee: Merck Sharp & Dohme Corp.Inventors: Joseph Terracciano, Nicole Miller Damour, Chun Jiang, Giovanni Fogliato, Giuseppe Alessandro Donadelli, Dario Resemini
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Publication number: 20170226126Abstract: Described herein are crystalline forms of a compound of formula (III?), including toluene solvates off A TD-CLE, as well as processes for the preparation thereof and use thereof in the preparation of cephalosporin compounds such as ceftolozane. Provided herein is a crystalline form of a compound of formula (III?): wherein X is CI, Br, or I; and R1 and R2 are each independently an oxygen protecting group; processes for making the crystalline form, and use of said form in the synthesis of antibacterial cephalosporins such as ceftolozane.Type: ApplicationFiled: August 14, 2015Publication date: August 10, 2017Applicant: Merck Sharp & Dohme Corp.Inventors: Kristos Adrian Moshos, Valdas Jurkauskas, Giovanni Fogliato, Manuel Scanu, You Seok Hwang
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Publication number: 20170101421Abstract: A method of forming a compound of formula (IIIa): wherein: R1 in each occurrence is independently selected from H, halogen, amino, C1-5 alkyl, C1-5 alkenyl and C1-5 alkynyl; R2 in each occurrence is independently selected from H, halogen, amino, C1-5 alkyl, C1-5 alkenyl and C1-5 alkynyl; R4 is C1-5 alkyl; and R6 is a C1-5 fluoroalkyl; and PG is a protecting group, the method comprising the step of reacting a compound of formula (IIa) with a compound of formula (VIII):Type: ApplicationFiled: May 14, 2015Publication date: April 13, 2017Applicant: Allecra Therapeutics SASInventors: Andrea Faini, Marco Forzatti, Giovanni Fogliato, Stefano Biondi
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Publication number: 20160279140Abstract: This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.Type: ApplicationFiled: March 31, 2016Publication date: September 29, 2016Inventors: Joseph Terracciano, Nicole Miller Damour, Chun Jiang, Giovanni Fogliato, Giuseppe Alessandro Donadelli, Dario Resemini
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Publication number: 20160193221Abstract: Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane prepared in the absence of tazobactam, tazobactam prepared in the absence of ceftolozane, and/or compositions where ceftolozane and tazobactam are first combined within a unit dosage form container.Type: ApplicationFiled: March 16, 2016Publication date: July 7, 2016Inventors: Joseph Terracciano, Nicole Miller Damour, Chun Jiang, Giovanni Fogliato, Giuseppe Alessandro Donadelli, Dario Resemini
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Patent number: 9320740Abstract: Pharmaceutical compositions are provided in unit dosage forms comprising ceftolozane and tazobactam in separate unit dosage form containers, ceftolozane prepared in the absence of tazobactam, tazobactam prepared in the absence of ceftolozane, and/or compositions where ceftolozane and tazobactam are first combined within a unit dosage form container.Type: GrantFiled: March 14, 2014Date of Patent: April 26, 2016Assignee: MERCK SHARP & DOHME CORP.Inventors: Joseph Terracciano, Nicole Miller Damour, Chun Jiang, Giovanni Fogliato, Giuseppe Alessandro Donadelli, Dario Resemini
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Publication number: 20160000921Abstract: This disclosure provides pharmaceutical compositions comprising ceftolozane, pharmaceutical compositions comprising ceftolozane and tazobactam, methods of preparing those compositions, and related methods and uses of these compositions.Type: ApplicationFiled: September 16, 2015Publication date: January 7, 2016Inventors: Joseph TERRACCIANO, Nicole Miller DAMOUR, Chun JIANG, Giovanni FOGLIATO, Giuseppe Alessandro DONADELLI, Dario RESEMINI
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Publication number: 20150150883Abstract: Pharmaceutical compositions can include ceftolozane lyophilized in the absence of tazobactam.Type: ApplicationFiled: November 3, 2014Publication date: June 4, 2015Applicant: CALIXA THERAPEUTICS, INC.Inventors: Chun Jiang, Joseph Terracciano, Nicole Miller Damour, Giovanni Fogliato, Giuseppe Alessandro Donadelli, Dario Resemini
