Abstract: Disclosed herein is a loading system (1) for implantable prostheses, specifically heart valve prostheses. The loading system (1) may be pre-mounted in a storage container (J) filled with a preservation solution with the prosthesis attached thereto, and may provide one or more deployment elements of a delivery instrument as receivers (4, 33) for the loading of the prosthesis (2).

Abstract: Compositions and methods of use comprising serotonin (5-HT) receptor agonists and NMDAR modulating substances, including especially certain substances classified as 5-HT2A agonists presently disclosed to exert NMDAR modulating effects, administered as modulators of neural plasticity, at non-psychedelic/psychotomimetic dosages, posology and formulations, for treatment of diseases and conditions and for improving functions (neuroplastogens).

Abstract: Disclosed herein is a deployment instrument including: a shaft (2) having a longitudinal axis (X1); a handle (3) at a first end of the shaft (2); and a carrier portion (4) at a second end of the shaft (2). The carrier portion(4) is configured for holding an expandable heart valve prosthesis in a radially collapsed condition for delivery to the implantation site. The carrier portion (4) includes a hub (5) fixed to the handle (3) via the shaft (2), a first deployment element (6) and a second deployment element (7), each of said first deployment element (6) and second deployment element (7) configured to hold a corresponding portion of an expandable heart valve prosthesis in a radially collapsed condition. A drive member (8) is provided which is configured to operate the first deployment element (6) and the second deployment element (7) in first and second opposite directions.

Abstract: Disclosed herein is a loading system (1) for implantable prostheses, specifically heart valve prostheses. The loading system (1) may be pre-mounted in a storage container (J) filled with a preservation solution with the prosthesis attached thereto, and may provide one or more deployment elements of a delivery instrument as receivers (4, 33) for the loading of the prosthesis (2).

Abstract: The disclosure relates to a holder (1) for a heart valve prosthesis (100) including a radially contractible armature (102) and a prosthetic valve carried by said armature (102). The holder (1) includes an annular member (2) having a longitudinal axis (xl) and comprising a plurality of supporting formations (3), said supporting formations (3) protruding radially inwardly of said annular member (2), and a locking member (4) configured for coupling with said annular member (2). Each supporting formation (3) includes a coupling profile or feature (9) configured for engaging the armature (102) of a heart valve prosthesis (100). The coupling profile or feature (9) being configured to prevent the displacement of the armature (102) along said longitudinal axis and being configured to prevent rotation of the armature (102) around the longitudinal axis (X1), while leaving the armature (102) unconstrained in a radially inward direction.

Abstract: A holder for a heart valve prosthesis, the holder including a hub portion having a longitudinal axis, an engagement portion coupled to the hub portion and including plural finger members variably positionable relative to the hub portion between a collapsed condition wherein the finger members are closed onto the hub portion and an expanded condition wherein the finger members radially protrude with respect to the hub portion to engage a heart valve prosthesis.

Abstract: A holder for a heart valve prosthesis, the holder including a hub portion having a longitudinal axis, an engagement portion coupled to the hub portion and including plural finger members variably positionable relative to the hub portion between a collapsed condition wherein the finger members are closed onto the hub portion and an expanded condition wherein the finger members radially protrude with respect to the hub portion to engage a heart valve prosthesis.

Abstract: A holder for heart valve prostheses, the holder including a hub portion having a longitudinal axis, an engagement portion coupled to the hub portion and including plural L-shaped finger members variably positionable relative to the hub portion between a collapsed condition wherein the finger members are closed onto the hub portion and an expanded condition wherein the finger members radially protrude with respect to the hub portion to engage a heart valve prosthesis.

Abstract: An extended anionic surfactant having the general formula: RO—(PO)n-YZ wherein R is a linear alkyl chain ranging from C6 to C36, a branched alkyl chain ranging from C6 to C36, or a mixture thereof; PO is a propyleneoxy group; Y is —SO3, —CH2CH2CH2—SO3, —CH2CH(CH3)—SO3, or —CH2COO; Z is a cation; and n is 1 to 50.

Abstract: Disclosed herein are various embodiments of a holder (1) for heart valve prostheses (V). Embodiments of the holder (1) include: a hub portion (2) having a longitudinal axis (X1), an engagement portion (4) coupled to the hub portion (2) and including plural finger members (5) variably positionable relative to the hub portion (2) between a collapsed condition wherein the finger members (5) are closed onto the hub portion (2) and an expanded condition wherein the finger members (5) radially protrude with respect to the hub portion (2) to engage a heart valve prosthesis (V). The finger members (5) are L-shaped. Also disclosed are a storage arrangement and delivery instrument and a kit for crimping, loading and delivering an expandable heart valve prosthesis (V).

Abstract: A diverter valve device (10) including a body (12), in which a chamber (14) is defined, which is able to be flown through by a pressurized fluid flow; a rotatory plug (16), which is mounted on the body (12) and is adapted to rotate about a rotation axis (X-X); at least one inlet (18), which is provided in the body (12) and is fluidly arranged upstream of the chamber (14); and a pair of outlets (20a, 20b), which stem from the body (12) and are fluidly arranged downstream of the chamber (14). The body (12) has a substantially axial seat (22a) and a substantially radial seat (22b), which are fluidly arranged between the chamber (14) and one outlet (20a) and the other outlet (20b), respectively. The plug (16) is suited to assume a first and a second operating condition, in which it (16) respectively frees and obstructs the substantially axial seat (22a) as well as respectively obstructs and frees the substantially radial seat (22b).

Abstract: An extended anionic surfactant having the general formula: RO—(PO)n—YZ wherein R is a linear alkyl chain ranging from C6 to C36, a branched alkyl chain ranging from C6 to C36, or a mixture thereof; PO is a propyleneoxy group; Y is —SO3, —CH2CH2CH2—SO3, —CH2CH(CH3)—SO3, or —CH2COO; Z is a cation; and n is 1 to 50.

Abstract: A portable device includes coded information reading means, digital image acquisition means and an illuminator, associated with the acquisition means for acquiring images. The illuminator is powerable by a driving signal which corresponds to a first current signal in a first operating mode for illuminating an image to be acquired and is powerable by the driving signal which corresponds to a second current signal in a second operating mode for emitting a visual indication indicating the outcome of the reading of the coded information, read by coded information reading means. The illuminator, which acts as a flash to acquire an image in the first operating mode, thus also acts as a visual indication of the reading outcome in the second operating mode and illuminates with a continuous or intermittent light the space in front of the illuminator to indicate to an operator that the coded information has been read.

Abstract: A diverter valve device (10) including a body (12), in which a chamber (14) is defined, which is able to be flown through by a pressurized fluid flow; a rotatory plug (16), which is mounted on the body (12) and is adapted to rotate about a rotation axis (X-X); at least one inlet (18), which is provided in the body (12) and is fluidly arranged upstream of the chamber (14); and a pair of outlets (20a, 20b), which stem from the body (12) and are fluidly arranged downstream of the chamber (14). The body (12) has a substantially axial seat (22a) and a substantially radial seat (22b), which are fluidly arranged between the chamber (14) and one outlet (20a) and the other outlet (20b), respectively. The plug (16) is suited to assume a first and a second operating condition, in which it (16) respectively frees and obstructs the substantially axial seat (22a) as well as respectively obstructs and frees the substantially radial seat (22b).

Abstract: A portable device includes coded information reading means, digital image acquisition means and an illuminator, associated with the acquisition means for acquiring images. The illuminator is powerable by a driving signal which corresponds to a first current signal in a first operating mode for illuminating an image to be acquired and is powerable by the driving signal which corresponds to a second current signal in a second operating mode for emitting a visual indication indicating the outcome of the reading of the coded information, read by coded information reading means. The illuminator, which acts as a flash to acquire an image in the first operating mode, thus also acts as a visual indication of the reading outcome in the second operating mode and illuminates with a continuous or intermittent light the space in front of the illuminator to indicate to an operator that the coded information has been read.