Abstract: Disclosed herein are Ral-antagonist compounds that covalently bind to binding sites in RalA, and efficaciously inhibit Ral activity. The compounds include aryl sulfonyl fluoride compounds of the general structure of wherein X and Y are independently C or N, and R4 is C1-C4 alkyl, —OCH3, —OCH2CH3, —OCH(CH3)2, —(SO2)CH3, —OH, or halo. These compounds expand Ral-inhibiting therapeutic options for treating Ral-driven cancers and one embodiment of the present disclosure is directed to the use of such compounds to treat cancer.

Abstract: The present disclosure generally relates to a personal care device comprising an immiscible conditioning composition formed by combining a hydrophilic matrix, such as a polymeric material, and a hydrophobic conditioning agent. More particularly, the present disclosure relates to a personal care device comprising a hydrophilic matrix, such as a polymeric material, and a hydrophobic conditioning agent dispersed therein, such as a silicone or a siloxane-based agent suitable for transferring from the device surface, and more particularly the matrix surface, to hair or skin surfaces in contact therewith.

Abstract: The present disclosure generally relates to a personal care device comprising an immiscible conditioning composition formed by combining a hydrophilic matrix, such as a polymeric material, and a hydrophobic conditioning agent. More particularly, the present disclosure relates to a personal care device comprising a hydrophilic matrix, such as a polymeric material, and a hydrophobic conditioning agent dispersed therein, such as a silicone or a siloxane-based agent suitable for transferring from the device surface, and more particularly the matrix surface, to hair or skin surfaces in contact therewith.

Abstract: A method for assessing insulation deterioration in a live underground power cable may include, in one embodiment, attaching a coupling device to a live underground power cable and using the coupling device to couple a test signal onto the power cable. The power cable may carry a normal AC power signal at a first frequency, while the test signal may have a second frequency different from the first frequency. The test signal may be detected after it has traveled a distance along the power cable. It may then be analyzed to determine a change in velocity and/or attenuation of the test signal as a function of the normal AC power signal. The severity of water trees in the power cable may be inferred based on the magnitude of the change.

Abstract: A method for assessing insulation deterioration in a live underground power cable may include, in one embodiment, attaching a coupling device to a live underground power cable and using the coupling device to couple a test signal onto the power cable. The power cable may carry a normal AC power signal at a first frequency, while the test signal may have a second frequency different from the first frequency. The test signal may be detected after it has traveled a distance along the power cable. It may then be analyzed to determine a change in velocity and/or attenuation of the test signal as a function of the normal AC power signal. The severity of water trees in the power cable may be inferred based on the magnitude of the change.

Abstract: The present disclosure generally relates to a method for cleaning a shaving device using a cleaning solution and preparation of the cleaning solution. More particularly, the present disclosure relates to a method of cleaning a shaving device using an environmentally friendly cleaning solution.

Abstract: The present disclosure generally relates to a method for cleaning a shaving device using a cleaning solution and preparation of the cleaning solution. More particularly, the present disclosure relates to a method of cleaning a shaving device using an environmentally friendly cleaning solution.

Abstract: The present disclosure is generally directed to a personal grooming product or device (e.g., foil shaver, rotary shaver, etc.) having a metal coating on one or more surfaces thereof, the grooming product being designed for contacting the skin (e.g., the human hand or face, or the skin of an animal, such as during the act of pet grooming). More specifically, the present disclosure is directed to a personal grooming product or device having a layer of some measurable thickness on such a surface, wherein the layer comprises or contains a tarnish resistant, hypoallergenic and/or antimicrobial silver-containing alloy.

Abstract: The present disclosure generally relates to a personal care device comprising an immiscible conditioning composition formed by combining a hydrophilic matrix, such as a polymeric material, and a hydrophobic conditioning agent. More particularly, the present disclosure relates to a personal care device comprising a hydrophilic matrix, such as a polymeric material, and a hydrophobic conditioning agent dispersed therein, such as a silicone or a siloxane-based agent suitable for transferring from the device surface, and more particularly the matrix surface, to hair or skin surfaces in contact therewith.

Abstract: The present disclosure is generally directed to a personal grooming product or device (e.g., foil shaver, rotary shaver, etc.) having a metal coating on one or more surfaces thereof, the grooming product being designed for contacting the skin (e.g., the human hand or face, or the skin of an animal, such as during the act of pet grooming). More specifically, the present disclosure is directed to a personal grooming product or device having a layer of some measurable thickness on such a surface, wherein the layer comprises or contains a tarnish resistant, hypoallergenic and/or antimicrobial silver-containing alloy.

Abstract: In a cutting blade assembly for an electric foil shaver, a first cutting blade of the assembly has a generally planar first face, a generally planar second face opposite the first face, and a peripheral cutting edge. The first cutting blade has at least one bump disposed on its first face. A second cutting blade of the assembly has a generally planar first face, a generally planar second face opposite the first face, and a peripheral cutting edge. The first and second cutting blades are arranged in generally parallel relationship with each other with the first face of the first cutting blade facing either the first face or the second face of the second cutting blade. The bump on the first face of the first cutting blade keeps the first and second cutting blades otherwise separated during a coating process in which the faces of the cutting blades are coated.

Abstract: In a cutting blade assembly for an electric foil shaver, a first cutting blade of the assembly has a generally planar first face, a generally planar second face opposite the first face, and a peripheral cutting edge. The first cutting blade has at least one bump disposed on its first face. A second cutting blade of the assembly has a generally planar first face, a generally planar second face opposite the first face, and a peripheral cutting edge. The first and second cutting blades are arranged in generally parallel relationship with each other with the first face of the first cutting blade facing either the first face or the second face of the second cutting blade. The bump on the first face of the first cutting blade keeps the first and second cutting blades otherwise separated during a coating process in which the faces of the cutting blades are coated.

Abstract: The present invention relates to surgical instruments having a housing or elongated cartridge, a frame and an apparatus for releasably connecting the housing to the frame. Typically, the housing has active elements which perform a particular function during a surgical procedure, such as forceps, graspers, clip appliers or staplers. The frame includes an actuating system for actuating the active elements, such as a pivotal handle or a release lever.

Abstract: An apparatus is disclosed for individually applying surgical clips endoscopically to body tissue which includes a frame, an elongated endoscopic section having clip closing jaws positioned at a distal end thereof and surgical clips slidably positioned therein, rotatably connected to a distal end of the frame such that the endoscopic section extends distally therefrom. The apparatus includes a system for individually advancing the surgical clips into the clip closing jaws and a system for closing the clip closing jaws. An interference mechanism is associated with the a release mechanism, and is configured, dimensioned and adapted to prevent actuation of the jaw closing system until a surgical clip is positioned between the clip closing jaws.