Patents by Inventor Giovanni M. Pauletti

Giovanni M. Pauletti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10488424
    Abstract: A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing. The analytical membrane (14) includes a porous hydrophilic sample portion (34), a porous hydrophilic analytical portion (36), and a porous hydrophilic wicking portion (38). The porosity of the analytical portion (36) differs from the porosity of the sample portion (34). The method utilizes the device to analyze blood coagulation in a whole blood sample from the distance travelled by the red blood cell leading edge (50) in a predetermined period of time.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: November 26, 2019
    Assignee: University of Cincinnati
    Inventors: Andrew J. Steckl, Giovanni M. Pauletti, Hua Li
  • Publication number: 20170074893
    Abstract: A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing. The analytical membrane (14) includes a porous hydrophilic sample portion (34), a porous hydrophilic analytical portion (36), and a porous hydrophilic wicking portion (38). The porosity of the analytical portion (36) differs from the porosity of the sample portion (34). The method utilizes the device to analyze blood coagulation in a whole blood sample from the distance travelled by the red blood cell leading edge (50) in a predetermined period of time.
    Type: Application
    Filed: March 3, 2015
    Publication date: March 16, 2017
    Applicant: University Of Cincinnati
    Inventors: Andrew J. Steckl, Giovanni M. Pauletti, Hua Li
  • Patent number: 8178123
    Abstract: A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: May 15, 2012
    Assignee: Femina Pharma Incorporated
    Inventors: Giovanni M. Pauletti, Donald C. Harrison, Kishorkumar J. Desai
  • Patent number: 7939098
    Abstract: Compositions and methods for vaginal, buccal or nasal transmucosal delivery of drugs and for cryoprotecting of cells and embryos. For cryoprotection, the composition consisting essentially consist of a non-ionizable glycol derivative. For transmucosal delivery, the compositions essentially consist of a non-ionizable glycol derivative in a combination with a pharmaceutically active agent. For transmucosal delivery, the non-ionizable glycol derivative may be further combined with a mucoadhesive agent and/or a penetration enhancer and/or lipophilic or hydrophilic carrier for adhesion to and transport through a mucosa. The compositions are particularly suitable for administration of drugs through a nasal, buccal and vaginal mucosa or for long-term preservation of cell or embryos.
    Type: Grant
    Filed: May 22, 2003
    Date of Patent: May 10, 2011
    Assignee: Femina Pharma Incorporated
    Inventors: Giovanni M. Pauletti, James H. Liu, Wolfgang A. Ritschell
  • Patent number: 7744916
    Abstract: A vaginal device for delivery of an anti-migraine or anti-nausea drug to the uterus and/or to the general circulation through vaginal mucosa. The device is at least partially coated with one or several layers of fluid impermeable material forming a cap, film, foam, foil or strip incorporated with mucoadhesive composition comprising the anti-migraine or anti-nausea drug.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: June 29, 2010
    Assignee: UMD, Inc.
    Inventors: Giovanni M. Pauletti, Michelle Wilson, Richard Soderstrom, Desai J. Kishorkumar, Wolfgang A. Ritschel
  • Publication number: 20090297585
    Abstract: pH modulated films and methods of their preparation. The film compositions include at least one component having a non-neutral pH when combined with water; and a pH modulated polymer system selected to reduce or prevent synerisis when combined with the non-neutral component in combination with aqueous media. The films demonstrate a non-self-aggregating uniform heterogeneity. Desirably, the films disintegrate in water and may be formed by a controlled drying process, extrusion process, or other process that maintains the required uniformity of the film.
    Type: Application
    Filed: May 30, 2008
    Publication date: December 3, 2009
    Inventors: Garry L. Meyers, Giovanni M. Pauletti, Kishorkumar Desai
  • Patent number: 7341737
    Abstract: A tampon adapted to deliver a therapeutic agent, the tampon including a tampon body having a distal end; and a dosage form affixed to the distal end of the tampon body, wherein the dosage form includes a formulation including a therapeutic agent, and wherein the dosage form comprises a plurality of layers. Also, a method for manufacturing a medicated tampon adapted to deliver a therapeutic agent, the method including manufacturing a tampon body having a distal end; producing a dosage form having a plurality of layers, wherein the dosage form includes a formulation including a therapeutic agent; and affixing the dosage form to the distal end of the tampon body.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: March 11, 2008
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Steven Craig Gehling, Donald C. Harrison, James H. Liu, Wolfgang A. Ritschel, Chris Clendening, Giovanni M. Pauletti
  • Patent number: 6982091
    Abstract: Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: January 3, 2006
    Assignee: UMD, Inc.
    Inventors: Giovanni M. Pauletti, James H. Liu, Leslie Z. Benet, Wolfgang A. Ritschel
  • Publication number: 20050276836
    Abstract: A vaginal device for delivering therapeutical and/or health-promoting agents. The vaginal device partly or completely coated by, covered by or combined with a coating or covering comprising a film, foam, strip, cap, cup or particles. The coating of the device comprises a mucoadhesive composition comprising a therapeutical and/or health-promoting agent.
    Type: Application
    Filed: July 12, 2005
    Publication date: December 15, 2005
    Inventors: Michelle Wilson, Kishorkumar J. Desai, Giovanni M. Pauletti, Mitchell K. Antoon, Chris Clendening
  • Patent number: 6905701
    Abstract: Devices, methods, and improved formulation for transmucosal vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the systemic circulation using a vaginal device comprising an improved bisphosphonate formulation for transmucosal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transmucosal delivery of bisphosphonates to the general circulation.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: June 14, 2005
    Assignee: UMD, Inc.
    Inventors: Giovanni M. Pauletti, Chris E. Clendening
  • Publication number: 20040151774
    Abstract: Polymer foams and films for delivery of therapeutic agents to and through nasal, oral or vaginal mucosa and cornified or non-cornified epithelium of labia and scrotum. Polymer foams or absorbable or non-absorbable films containing a therapeutic agent incorporated therein wherein said agent is released from said foams or films upon placement of said foam or film on the surface epithelium of nasal, oral, or vaginal labia or scrotum. The foam or the film has a controllable rate of gelling, swelling and degradation and is preformed into a device or is applied as a coating to a surface of a more complex drug delivery system.
    Type: Application
    Filed: October 31, 2003
    Publication date: August 5, 2004
    Inventors: Giovanni M. Pauletti, Kishorkumar J. Desai, Susan L. Roweton, Donald C. Harrison, Lynda M. Sanders
  • Publication number: 20040043071
    Abstract: A method, composition and device for intravaginal mucosal or transmucosal delivery of antimigraine and/or antinausea drugs to a female subject for treatment of migraine and other diseases accompanied by or associated with nausea and vomiting. A mucoadhesive composition comprising antimigraine or antinausea drugs, mucoadhesive agent, penetration enhancer or sorption promoter and a hydrophilic or lipophilic carries. An intravaginal device for delivery of antimigraine or antinausea drugs.
    Type: Application
    Filed: June 20, 2003
    Publication date: March 4, 2004
    Inventors: Giovanni M. Pauletti, Richard Soderstrom, Wolfgang A. Ritschel
  • Publication number: 20040005345
    Abstract: Devices, methods, and improved formulation for transmucosal vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the systemic circulation using a vaginal device comprising an improved bisphosphonate formulation for transmucosal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transmucosal delivery of bisphosphonates to the general circulation.
    Type: Application
    Filed: January 22, 2003
    Publication date: January 8, 2004
    Inventors: Giovanni M. Pauletti, Chris E. Clendening
  • Publication number: 20030219472
    Abstract: Compositions and methods for vaginal, buccal or nasal transmucosal delivery of drugs and for cryoprotecting of cells and embryos. For cryoprotection, the composition consisting essentially consist of a non-ionizable glycol derivative. For transmucosal delivery, the compositions essentially consist of a non-ionizable glycol derivative in a combination with a pharmaceutically active agent. For transmucosal delivery, the non-ionizable glycol derivative may be further combined with a mucoadhesive agent and/or a penetration enhancer and/or lipophilic or hydrophilic carrier for adhesion to and transport through a mucosa. The compositions are particularly suitable for administration of drugs through a nasal, buccal and vaginal mucosa or for long-term preservation of cell or embryos.
    Type: Application
    Filed: May 22, 2003
    Publication date: November 27, 2003
    Inventors: Giovanni M. Pauletti, James H. Liu, Wolfgang A. Ritschell
  • Patent number: 6572874
    Abstract: Devices, methods, and compositions for vaginal delivery of bisphosphonates. A targeted site delivery of bisphosphonates to the vagina using a medicated intravaginal device comprising a bisphosphonate composition formulated for transvaginal delivery. A method for treatment of osteoporosis and related bone and skeleton diseases, for prevention of bone breakdown and loss of bone mass and strength by intravaginal administration of bisphosphonates to the vagina and transvaginal delivery of bisphosphonates to the general circulation.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: June 3, 2003
    Assignee: UMD, Inc.
    Inventors: Donald C. Harrison, James H. Liu, Giovanni M. Pauletti, Wolfgang A. Ritschel
  • Publication number: 20030049302
    Abstract: Devices, methods, and compositions for cancer therapy by administration of chemotherapeutic agents and/or inhibitors of membrane efflux systems to the vagina for topical and systemic tumor targets.
    Type: Application
    Filed: August 21, 2002
    Publication date: March 13, 2003
    Inventors: Giovanni M. Pauletti, James H. Liu, Leslie Z. Benet, Wolfgang A. Ritschel