Patents by Inventor Giovanni Mambrini

Giovanni Mambrini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210283063
    Abstract: The present invention relates to a process for preparing erythrocytes loaded with one or more substance of pharmaceutical interest. The present invention is also directed to loaded erythrocytes thus obtained and pharmaceutical compositions comprising said population of loaded erythrocytes as well as therapeutic application thereof, in particular in the treatment of Ataxia telangiectasia.
    Type: Application
    Filed: October 29, 2020
    Publication date: September 16, 2021
    Applicant: ERYDEL S.P.A.
    Inventors: Giovanni MAMBRINI, Luca Benatti, Giovanni Capogrossi, Marco Mandolini
  • Patent number: 10849858
    Abstract: The present invention relates to a process for preparing erythrocytes loaded with one or more substance of pharmaceutical interest. The present invention is also directed to loaded erythrocytes thus obtained and pharmaceutical compositions comprising said population of loaded erythrocytes as well as therapeutic application thereof, in particular in the treatment of Ataxia telangiectasia.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: December 1, 2020
    Assignee: ERYDEL S.P.A.
    Inventors: Giovanni Mambrini, Luca Benatti, Giovanni Capogrossi, Marco Mandolini
  • Publication number: 20160051482
    Abstract: The present invention relates to a process for preparing erythrocytes loaded with one or more substance of pharmaceutical interest. The present invention is also directed to loaded erythrocytes thus obtained and pharmaceutical compositions comprising said population of loaded erythrocytes as well as therapeutic application thereof, in particular in the treatment of Ataxia telangiectasia.
    Type: Application
    Filed: May 9, 2014
    Publication date: February 25, 2016
    Inventors: Giovanni MAMBRINI, Luca BENATTI, Giovanni CAPOGROSSI, Marco MANDOLINI
  • Patent number: 9089640
    Abstract: A portable and highly automated apparatus and method for introducing at least one compound within erythrocytes; the apparatus comprises a reusable part provided with mechanical elements such as pumps and valves and electronic units such as a control unit; the apparatus also comprises a disposable part, which is adapted to come into contact with the sample containing the erythrocytes and is provided with a system of tubes made of deformable material, a plurality of reservoirs and one or more filters; the apparatus allows a further concentration of the erythrocytes after they have been treated; the apparatus allows to introduce the compound in the erythrocytes in a virtually totally automated manner.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: July 28, 2015
    Assignee: ERYDEL S.p.A.
    Inventors: Giovanni Mambrini, Sonja Serafini
  • Publication number: 20130101463
    Abstract: A portable and highly automated apparatus and method for introducing at least one compound within erythrocytes; the apparatus comprises a reusable part provided with mechanical elements such as pumps and valves and electronic units such as a control unit; the apparatus also comprises a disposable part, which is adapted to come into contact with the sample containing the erythrocytes and is provided with a system of tubes made of deformable material, a plurality of reservoirs and one or more filters; the apparatus allows a further concentration of the erythrocytes after they have been treated; the apparatus allows to introduce the compound in the erythrocytes in a virtually totally automated manner.
    Type: Application
    Filed: April 26, 2011
    Publication date: April 25, 2013
    Applicant: ERYDEL S.P.A.
    Inventors: Giovanni Mambrini, Sonja Serafini
  • Publication number: 20070196911
    Abstract: A bioreactor having: a reaction chamber; a first port adapted for the introduction of human cells; a second port adapted for gas exchange, the second port comprising a filter; a third port adapted for introducing culture medium; a fourth port adapted for sampling cells; and a fifth port adapted for harvesting the human cells after they have been cultured.
    Type: Application
    Filed: January 10, 2007
    Publication date: August 23, 2007
    Inventors: Giovanni Mambrini, Giuseppe Astori, Ivo Panzani, Leonardo Bigi, Valentina Adami, Walter Malangone, Elisabetta Falasca
  • Publication number: 20020195104
    Abstract: An apparatus for increasing the humidification of the air stream breathed by a patient, having a tubular body that can be coupled to a heat and moisture exchange filter and forms a channel for the passage of an air stream. At least one portion of the channel is provided by a membrane impermeable to gases and permeable to ions and molecules with a partial charge. The membrane delimits an interspace that is external to the channel and allows passage of a water vapor flow.
    Type: Application
    Filed: May 16, 2002
    Publication date: December 26, 2002
    Inventors: Massimo Fini, Giovanni Mambrini