Abstract: The present invention relates to an arrangement (10) for measuring small amounts of a first medium (202) in a third medium (206) and/or of a substance in the first medium (202), said third medium (206) comprising said first medium (202) and a second medium (204), said second medium (204) comprising a known concentration of a magnetic material, wherein said arrangement comprises: magnetization means (12) for providing a variable magnetic field (20) in a region of action (22), in which a probe (18; 208) of said third medium (206) is placed for measurement, receiving means (14) for acquiring a detection signal of the magnetization of said probe (12) in said region of action (22) after application of said variable magnetic field (20), and evaluation means (214) for evaluating said detection signal and comparing it to calibration measurements of the magnetization of at least one calibration sample to derive an information about the amount of said first medium (202) in said third medium (206) and/or of said substan

Abstract: A transdermal drug delivery system (100) for providing controlled doses of a drug through the skin of a human or other animal is disclosed. In one embodiment, the transdermal drug delivery system (100) includes a substrate (110) designed to adhere to skin and a transdermal injector array (140) coupled to the substrate (110). The transdermal array (140) has one or more transdermal injectors (210, 220, 230) embedded within including a first transdermal injector (210) configured to administer or provide a first substance to the skin at a speed great enough to produce an appreciable breach in the surface of the skin.

Abstract: The invention relates to a device for needleless transdermal drug delivery. The device according to the invention comprises an actuator (104) and a support (102) which has a support stiffness. The actuator (104) has a driver part (108) and a support part (106), which support part (106) is connected to the support and which driver part (108) is displaceable with regard to the support part (106) along an axis of displacement (110). The device according to the invention is characterized in that the support stiffness provides a substantially zero displacement of the actuator's support part (106) along the driver's axis of displacement (110) during a displacement of the driver part (108) along said axis with regard to the support part (106).

Abstract: A nozzle for jetting devices is described comprising e.g. one patterned silicon substrate enabling semiconductor mass production. The method of manufacturing the nozzle is characterized by using one mask layer deposited on the silicon substrate. The etching of the silicon substrate is done by means of a first isotropic etching step and a second anisotropic etching step through the mask layer, resulting in a perfectly aligned nozzle.

Abstract: In order to provide a wearable drug delivery device for long term administration of drugs not employing a needle or canula, it is suggested according to the present invention that a wearable drug delivery device comprises a tubular reservoir (1) having an outlet end from which a drug may be expelled and a second end, a high-speed jet pump (2) for transdermal, needle-less micro-jet drug delivery, being connected to the outlet end of the tubular reservoir, a venting valve, being connected to the second end of the reservoir.

Abstract: The invention provides an ink jet device and method for producing a biological assay substrate (41) by releasing a plurality of substances onto the substrate (41) The device comprises at least a print head and a plurality of substance containers (60, 61, 62) connectable thereto, and mounting means (55) for the containers, whereby at least part of the containers (60, 61, 62) is provided with identification means (63) The device further comprises reading means to read information contained in the identification means (63).

Abstract: A transdermal drug delivery system (100) for providing controlled doses of a drug through the skin of a human or other animal is disclosed. In one embodiment, the transdermal drug delivery system (100) includes a substrate (110) designed to adhere to skin and a transdermal injector array (140) coupled to the substrate (110). The transdermal array (140) has one or more transdermal injectors (210, 220, 230) embedded within including a first transdermal injector (210) configured to administer or provide a first substance to the skin at a speed great enough to produce an appreciable breach in the surface of the skin.

Abstract: It is described a drug delivery system (100) that is adapted to infuse a drug in a profile related to the activity status of a patient (595). The system comprises acceleration sensors (112), dedicated electronics (120) and software to monitor the patient's activity and maintain control over the drug-release profile. The described system (100) enables a personalized treatment of patients (595) by monitoring their individual activity status and coupling this information to a drug delivery following appropriate delivery profiles. The system (100) may be provided with a memory in order to store a time dependence of activity data. This time dependence may be used by physicians to monitor, support and adapt their therapy for the patients. The system (100) maybe realized as a closed-loop system for monitoring and treatment of various diseases such as Parkinson s disease. Accelerations sensors (112) may be used in order to directly monitor a positional state and/or motions of the patient's body.

Abstract: A transdermal drug delivery system (100) for providing controlled doses of a drug through the epidermis of a human or other animal is disclosed. In one embodiment, the transdermal drug delivery system (100) includes a substrate (110) having an array of one or more electrode pairs (140) disposed thereon and a gel (130) disposed on the substrate (110) and in electrical contact with each electrode (142, 144) of the one or more electrode pairs (140). The gel (130) contains at least a first medicating agent and is configured to change a rate of release of the first medicating agent based on at least one of a voltage or current provided by the electrode pairs (140).

Abstract: An electrotransport device for transdermal drug delivery has a number of electrodes and driving circuitry for supplying driving signals to the number of electrodes. The electrodes are connected to the driving circuitry in rows and columns. The driving circuitry has row driving circuitry for supplying a row signal to a row of electrodes, and column driving circuitry for supplying a column signal to a column of electrodes. A predetermined electrode is individually addressable by supplying a row signal to a corresponding row of electrodes and a column signal to a corresponding column of electrodes.

Abstract: The invention refers to an electrically actuated, needle-free injection device. The main field of application is drug delivery. The device is based on a piezoelectric actuator (11). The device enables controlled, continuous, tuneable drug delivery. The device enables painless injection, personalized and programmable dosage profiles. The device is designed, both to pierce the epidermis for trans-epidermal drug delivery and to deliver controlled amounts of fluid (transdermal, electronic pill and implantable drug delivery). This type of device enables personalized drug delivery and is an enabling component for closed-loop drug delivery systems.

Abstract: The invention relates to an electroluminescent display panel (2) comprising a substrate and a plurality of display pixels (3) including an electroluminescent material defined on or over said substrate. The display panel (2) further includes at least one microcontact printed hydrophobic layer (11) between adjacent display pixels (3). The invention further relates to a method for manufacturing such a display panel. The method avoids the need to apply photoresist barriers for containing the liquid electrolumi-nescent material.

Abstract: A method is proposed for measuring water permeability of substrates (1). A reactive compound (Ca, Ba) which reacts with a diffusing material, e.g. water, is applied on the substrate and the change in time of transmissivity, reflectivity of the layer is monitored in time.

Abstract: A method is proposed for measuring water permeability of substrates (1). A reactive compound (Ca, Ba) which reacts with a diffusing material, e.g. water, is applied on the substrate and the change in time of transmissivity, reflectivity of the layer is monitored in time.

Abstract: Improved seal for flexible organic light emitting displays are provided. For the purpose of the present invention it is realisd that a homogenous seal cannot provide for the combination of resuired robusness and required impermeability, which are essential for the life time of the display. Therefore, a seal comprising an inner seal portion and an outer seal portion is proposed. The outer seal portion is flexible as compared to the inner seal portion and the inner seal portion is impermeable as compared to the outer seal portion and being deposited between the outer seal portion and the display element.

Abstract: A method is proposed for measuring water permeability of substrates (1). A reactive compound (Ca, Ba) which reacts with a diffusing material, e.g. water, is applied on the substrate and the change in time of transmissivity, reflectivity of the layer is monitored in time.

Abstract: The invention pertains to a method of obtaining a pair of substrates spaced from each other by spacers comprising: a) providing a first substrate overlaid with a first layer with a patterned hydrophobic second layer or a patterned hydrophilic second layer that can take on an electrostatic charge; and b) optionally treating the parts of the first layer that are not covered with the hydrophobic or hydrophilic second layer to form a patterned hydrophilic third layer that can take on an electrostatic charge with a sign that is opposite to the sign of the electrostatic charge that can be taken on by the hydrophilic second layer, if the second layer is a hydrophilic layer; c) providing at least one of the first, second, and third layer with an electrostatic charge; d) contacting the electrostatically charged patterned first substrate with a dispersion of polymeric particles (spacers), which are functionalized so that the polymeric particles at their surface can take on an electrostatic charge with a sign opposite t

Abstract: A bistable liquid crystal display device can be erased by the application of a mechanical pressure P at a section 20 of the display. The pressure induces a flow of the liquid crystal (5) material into an expansion chamber (22). The induced flow causes a transition from the non-reflecting to the reflecting state, thus eliminating the necessity of high voltage erasing voltages.

Abstract: A bistable liquid crystal display device can be erased by the application of a mechanical pressure P at a section 20 of the display. The pressure induces a flow of the liquid crystal (5) material into an expansion chamber (22). The induced flow causes a transition from the non-reflecting to the reflecting state, thus eliminating the necessity of high voltage erasing voltages.

Abstract: Similar patterns of spacer ribs (7, 8) are applied on the two substrates (3, 4) of a display. Small misalignments are corrected by the shape and positioning of the patterns when the two substrates are pressed together, for example, in a reel-to-reel process.