Abstract: The present disclosure identifies RNAs (including mRNAs and miRNAs) that are bound by LIN-28 in C. elegans. Many of these RNAs have clear human orthologs, and many of these human orthologs are common druggable targets in cancer and/or other diseases, such as kinases, phosphatases, methyltransferases, phosphodiesterases, etc. Accordingly, the present disclosure provides biological targets for LIN-28 expressing cancers, and which are thus useful for selecting chemical and/or biological agents for cancer treatment.

Abstract: A dashboard for a road vehicle; the dashboard having: a digital screen; and an analog instrument, which is provided with a circular support element and a pointer that moves inside the support element; the analog instrument can be arranged in an operating position, in which the analog instrument overlaps the digital screen so that the support element of the analog instrument covers a corresponding part of said digital screen; and the support element of the analog instrument is opaque and has a plurality of through openings, through which the light generated by the underlying digital screen can come out.

Abstract: A dashboard for a road vehicle; the dashboard having: a digital screen; and an analogue instrument, which is provided with a circular support element and a pointer that moves inside the support element; the analogue instrument can be arranged in an operating position, in which the analogue instrument overlaps the digital screen so that the support element of the analogue instrument covers a corresponding part of said digital screen; and the support element of the analogue instrument is opaque and has a plurality of through openings, through which the light generated by the underlying digital screen can come out.

Abstract: An embodiment of an electrical system of a vehicle with electric propulsion achieved by at least one electrical machine; the electrical system has: a storage section provided with at least one battery including of a plurality of cells, each of which is coupled in series with the other cells and is provided with a bypass branch that is coupled in parallel to the cell and has a bypass switch; a section of traction that interacts with the electric machine and is equipped with a power electronic converter that exchanges electrical energy with the storage section; and a section of the auxiliaries, which powers auxiliary services of the vehicle, has a buffer battery and is electrically powered by the storage section; a first connector switch coupling the storage section to the section of traction; and a second connector switch coupling the storage section to the section of the auxiliaries.

Abstract: A method for arranging an accumulating device in proximity of a floor of a vehicle forming a bottom wall of a passenger compartment of the vehicle itself; the accumulating device has a heating base wall which is free from heat insulation, and a non-heating base wall which is parallel and opposite to the heating base wall and is provided with a heat-insulating material layer; and the method provides for the steps of arranging the accumulating device in a seating obtained in proximity of the floor; and implementing the accumulating device with a symmetry allowing the reversal of the accumulating device itself within the seating obtained in proximity of the floor in such a way that the heating base wall may be equally either facing upwards and then towards the passenger compartment or facing downwards and then towards the external environment.

Abstract: A method for starting an internal combustion thermal engine of a hybrid vehicle having: the thermal engine provided with a drive shaft; at least one pair of driving wheels; a transmission, which transmits the motion from the thermal engine to the driving wheels and has a clutch; and an electric machine, which is mechanically connected to the clutch downstream of the clutch, so that the clutch is interposed between the electric machine and the thermal engine; the starting method includes the steps of: opening the clutch to separate the electric machine from the thermal engine; separating the electric machine from the driving wheels; making the electric machine rotate by operating the electric machine as a motor; and closing the clutch when the electric machine reaches a launch rotation speed.

Abstract: An embodiment of a motoring aid method and system for a road vehicle, whereby a motoring aid information item is generated as the road vehicle travels along a road having a road surface; the information is converted into a graphic display image; and the image is projected onto a portion of the road surface ahead of the road vehicle, to allow the driver of the road vehicle to view the image without distracting the driver's attention from the road.

Abstract: An air conditioning system for a passenger compartment of a road vehicle; the air conditioning system has an elongated upper air inlet, which comes out through a top surface of a dashboard of the passenger compartment, close to a windscreen, extends substantially along the whole of the top surface of the dashboard, and is directed towards the passenger compartment to direct airflow tangent to the top surface of the dashboard and over the top surface.

Abstract: Described herein is a mounting system with measurement of the weight of the occupant for a seat of a motor vehicle; the mounting system has a bottom frame rigidly connected to the bodywork of the motor vehicle, a top frame, which supports the seat and is mounted in a floating way on the bottom frame, and a plurality of weight sensors, each of which is set between the bottom frame and the top frame and is connected to the bottom frame or to the top frame by means of a single bolt integrated in the weight sensor itself and locked by a nut; a surface of the nut facing the weight sensor has a spherical shape, and set between the nut and the frame is a washer having a spherical central surface, which reproduces in negative form the shape of the corresponding spherical surface of the nut.

Abstract: An embodiment of an electrical system of a vehicle with electric propulsion achieved by at least one electrical machine; the electrical system has: a storage section provided with at least one battery including of a plurality of cells, each of which is coupled in series with the other cells and is provided with a bypass branch that is coupled in parallel to the cell and has a bypass switch; a section of traction that interacts with the electric machine and is equipped with a power electronic converter that exchanges electrical energy with the storage section; and a section of the auxiliaries, which powers auxiliary services of the vehicle, has a buffer battery and is electrically powered by the storage section; a first connector switch coupling the storage section to the section of traction; and a second connector switch coupling the storage section to the section of the auxiliaries.

Abstract: A car provided with: a chassis supporting a pair of front wheels which turn about a first horizontal rotation axis and a pair of rear wheels which turn about a second horizontal rotation axis; a passenger compartment obtained between the front wheels and the rear wheels; and at least one pair of front doors, each of which is hinged to the chassis by means of a hinge to turn about a third rotation axis between an opening position and a closing position of the passenger compartment; the hinges of the front doors are arranged in proximity to the first rotation axis of the front wheels so that the projection on a horizontal plane of the hinges is within the rectangular area comprised between the two front wheels.

Abstract: A method for starting an internal combustion thermal engine of a hybrid vehicle having: the thermal engine provided with a drive shaft; at least one pair of driving wheels; a transmission, which transmits the motion from the thermal engine to the driving wheels and has a clutch; and an electric machine, which is mechanically connected to the clutch downstream of the clutch, so that the clutch is interposed between the electric machine and the thermal engine; the starting method includes the steps of: opening the clutch to separate the electric machine from the thermal engine; separating the electric machine from the driving wheels; making the electric machine rotate by operating the electric machine as a motor; and closing the clutch when the electric machine reaches a launch rotation speed.

Abstract: A method for arranging an accumulating device in proximity of a floor of a vehicle forming a bottom wall of a passenger compartment of the vehicle itself; the accumulating device has a heating base wall which is free from heat insulation, and a non-heating base wall which is parallel and opposite to the heating base wall and is provided with a heat-insulating material layer; and the method provides for the steps of arranging the accumulating device in a seating obtained in proximity of the floor; and implementing the accumulating device with a symmetry allowing the reversal of the accumulating device itself within the seating obtained in proximity of the floor in such a way that the heating base wall may be equally either facing upwards and then towards the passenger compartment or facing downwards and then towards the external environment.

Abstract: An air-conditioning system for the passenger compartment of a vehicle. The air-conditioning system includes an air-treatment unit and with a series of ventilation outlets distributed inside the passenger compartment and connected to the air-treatment unit. Some of the ventilation outlets are mounted on the side surface of a tubular body, which is set in a bottom portion of the passenger compartment. An internal pipe communicates with the air-treatment unit, and is mounted to oscillate about a longitudinal axis thereof.

Abstract: An embodiment of a motoring aid method and system for a road vehicle, whereby a motoring aid information item is generated as the road vehicle travels along a road having a road surface; the information is converted into a graphic display image; and the image is projected onto a portion of the road surface ahead of the road vehicle, to allow the driver of the road vehicle to view the image without distracting the driver's attention from the road.

Abstract: Described herein is a mounting system with measurement of the weight of the occupant for a seat of a motor vehicle; the mounting system has a bottom frame rigidly connected to the bodywork of the motor vehicle, a top frame, which supports the seat and is mounted in a floating way on the bottom frame, and a plurality of weight sensors, each of which is set between the bottom frame and the top frame and is connected to the bottom frame or to the top frame by means of a single bolt integrated in the weight sensor itself and locked by a nut; a surface of the nut facing the weight sensor has a spherical shape, and set between the nut and the frame is a washer having a spherical central surface, which reproduces in negative form the shape of the corresponding spherical surface of the nut.

Abstract: An air conditioning system for a passenger compartment of a road vehicle; the air conditioning system has an elongated upper air inlet, which comes out through a top surface of a dashboard of the passenger compartment, close to a windscreen, extends substantially along the whole of the top surface of the dashboard, and is directed towards the passenger compartment to direct airflow tangent to the top surface of the dashboard and over the top surface.

Abstract: A car provided with: a chassis supporting a pair of front wheels which turn about a first horizontal rotation axis and a pair of rear wheels which turn about a second horizontal rotation axis; a passenger compartment obtained between the front wheels and the rear wheels; and at least one pair of front doors, each of which is hinged to the chassis by means of a hinge to turn about a third rotation axis between an opening position and a closing position of the passenger compartment; the hinges of the front doors are arranged in proximity to the first rotation axis of the front wheels so that the projection on a horizontal plane of the hinges is within the rectangular area comprised between the two front wheels.

Abstract: A steering wheel for a vehicle includes a circular member operated by a driver of the vehicle to control a steering shaft mounted for rotation inside a steering column, the free end of which is fitted with a box body for housing an air bag and having at least one control lever.

Abstract: An adjustable set of pedals for a motor vehicle provided with at least two pedals for acceleration and, respectively, braking of the motor vehicle, which are mounted on a supporting element. A position of the supporting with respect to a fixed frame of the motor vehicle is controlled selectively by a regulation device defined by a crank mechanism set between the supporting element and the frame itself.