Patents by Inventor Giovanni Talei Franzesi
Giovanni Talei Franzesi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240148329Abstract: An exemplary vascular neural interface device/configuration and method can be provided for at least one of stimulating or recording the nervous system. For example, a package can be provided which can be inserted within a blood vessel. The package can include at least one transducer, at least one electrode, and at least one integrated circuit. The at least one transducer can receive or transmit a wireless signal which is used to provide energy or communicate with the at least one integrated circuit to at least one of record or stimulate the nervous system using recording electronics or stimulating electronics.Type: ApplicationFiled: November 13, 2023Publication date: May 9, 2024Inventors: Kenneth L. SHEPARD, John William STANTON, Giovanni Talei FRANZESI, Ed BOYDEN
-
Publication number: 20190175372Abstract: An electronic intravascular device is placed in tight contact with vessel walls and is used for electrical stimulation and/or electrical recording of the vessel wall and surrounding target tissue. The electrodes may operate via connectors interfacing them to external hardware or may incorporate electronics to allow wireless power, information transfer, and control. The device includes an internal skeleton, a flexible substrate attached to the exterior of the skeleton, at least one pair of electrodes located on the substrate, and power and control circuitry connected to the electrodes. The power and control circuitry may include connectors for direct powering of the electrodes or circuit elements for wireless powering of the device by RF-based, optical-based, ultrasound-based, piezoelectric, or vibrational energy harvesting methods.Type: ApplicationFiled: July 23, 2018Publication date: June 13, 2019Applicants: Massachusetts Institute of Technology, Washington UniversityInventors: Edward Stuart Boyden, Giovanni Talei Franzesi, Christian Wentz, Nir Grossman, Elazer R. Edelman, Colin Derdeyn, Eric Leuthardt
-
Patent number: 9668804Abstract: In an automated methodology for carrying out in vivo cell patch clamping, a cell patch clamping device is automatically moved into position and targeted to a neuron. Neuron contact is determined by analyzing the temporal series of measured resistance levels at the cell patch clamping device as it is moved. The difference between successive resistance levels is computed and compared to a threshold, which must be exceeded for a minimum number of computations before neuron contact is assumed. Pneumatic control methods are used to achieve gigaseal formation and cell break-in, leading to whole-cell patch clamp formation. An automated robotic system capable of performing this methodology automatically performs patch clamping in vivo, automatically detecting cells by analyzing the temporal sequence of electrode impedance changes.Type: GrantFiled: November 13, 2012Date of Patent: June 6, 2017Assignees: Massachusetts Institute of Technology, Georgia Tech Research CorporationInventors: Suhasa Bangalore Kodandaramaiah, Edward Stuart Boyden, Crag Richard Forest, Brian Yichiun Chow, Giovanni Talei Franzesi
-
Publication number: 20160000590Abstract: An electronic intravascular device is placed in tight contact with vessel walls and is used for electrical stimulation and/or electrical recording of the vessel wall and surrounding target tissue. The electrodes may operate via connectors interfacing them to external hardware or may incorporate electronics to allow wireless power, information transfer, and control. The device includes an internal skeleton, a flexible substrate attached to the exterior of the skeleton, at least one pair of electrodes located on the substrate, and power and control circuitry connected to the electrodes. The power and control circuitry may include connectors for direct powering of the electrodes or circuit elements for wireless powering of the device by RF-based, optical-based, ultrasound-based, piezoelectric, or vibrational energy harvesting methods.Type: ApplicationFiled: April 7, 2015Publication date: January 7, 2016Applicants: Washington University, Massachusetts Institute of TechnologyInventors: Edward Stuart Boyden, Giovanni Talei Franzesi, Christian Wentz, Nir Grossman, Elazer R. Edelman, Colin Derdeyn, Eric Leuthardt
-
Patent number: 8910638Abstract: In exemplary implementations of this invention, high-throughput screening of a mammalian brain is performed to locate neural circuit targets of interest. A variety of search patterns may be used for this neural screening, including (a) iterative subdivision, (b) serial search, and (c) combinatorial. To perform this neural screening, an array of optical fibers (or an array of waveguides) is inserted into the brain. Alternately, the array is positioned adjacent to the brain. Each fiber or waveguide in the array is coupled to a light source (LED or laser). The brain has been previously sensitized to light, using genetically encoded optical neural control reagents, which are delivered either using viruses or via transgenic means. In the screening, the array is used to optically perturb the brain. For example, the neurons of the brain may be activated by one color of light, and/or silenced by another color of light.Type: GrantFiled: October 24, 2011Date of Patent: December 16, 2014Assignee: Massachusetts Institute of TechnologyInventors: Edward Boyden, Jacob Bernstein, Christian Wentz, Giovanni Talei Franzesi, Michael Baratta, Brian Allen, Anthony Zorzos, Jorg Scholvin, Clifton Fonstad
-
Publication number: 20120089205Abstract: In exemplary implementations of this invention, high-throughput screening of a mammalian brain is performed to locate neural circuit targets of interest. A variety of search patterns may be used for this neural screening, including (a) iterative subdivision, (b) serial search, and (c) combinatorial. To perform this neural screening, an array of optical fibers (or an array of waveguides) is inserted into the brain. Alternately, the array is positioned adjacent to the brain. Each fiber or waveguide in the array is coupled to a light source (LED or laser). The brain has been previously sensitized to light, using genetically encoded optical neural control reagents, which are delivered either using viruses or via transgenic means. In the screening, the array is used to optically perturb the brain. For example, the neurons of the brain may be activated by one color of light, and/or silenced by another color of light.Type: ApplicationFiled: October 24, 2011Publication date: April 12, 2012Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Edward Boyden, Jacob Bernstein, Christian Wentz, Giovanni Talei Franzesi, Michael Baratta, Brian Allen, Anthony Zorzos, Jorg Scholvin, Clifton Fonstad
-
Publication number: 20110087126Abstract: According to principles of this invention, the photoelectrochemical effect (“PE effect”) may be greatly reduced or eliminated, even when an electrode is immersed in an electrolyte and exposed to light, by using a transparent conductor to record electrical activity. Thus, an electrode with a clear conductor may be used to accurately record electrical activity of neurons and other cells that are exposed to light in vivo or in vitro. Such an electrode eliminates or greatly reduces the artifacts that would otherwise be caused by light due to the PE effect.Type: ApplicationFiled: June 28, 2010Publication date: April 14, 2011Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Anthony Zorzos, Clifton Fonstad, Edward Boyden, Giovanni Talei Franzesi, August Dietrich