Patents by Inventor Giovanni Tonon

Giovanni Tonon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MICRO-DROPLET DISH
    Publication number: 20230256449
    Abstract: A micro-droplet plate including at least one fixed element which is a rigid flat support which has an upper face and a lower face, having, on said upper face, wells connected together by microchannels, said wells being delimited by a hydrophobic rim and crossed by a hole, where said wells and said microchannels define at least one microfluidic circuit; and moving elements, received in said wells through said holes, which are cylinders having an upper base and a lower base. The moving elements move, even independently of each other, along their vertical axis, and the upper base of said moving elements includes a hydrophilic surface with relief items.
    Type: Application
    Filed: April 28, 2021
    Publication date: August 17, 2023
    Applicants: POLITECNICO DI MILANO, FONDAZIONE CENTRO SAN RAFFAELE
    Inventors: Elena BIANCHI, Oronza Antonietta BOTRUGNO, Gabriele Angelo DUBINI, Monica PIERGIOVANNI, Giovanni TONON, Paola DE STEFANO, Luca LEONI, Pietro OLDANI
  • STK4 inhibitors for treatment of hematologic malignancies
    Patent number: 10710978
    Abstract: The application relates to compounds of Formula (I?): which modulate the activity of a kinase (e.g., STK4), a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease or disorder associated with the modulation of a kinase, such as STK4.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: July 14, 2020
    Assignees: DANA-FARBER CANCER INSTITUTE, INC., FONDAZIONE CENTRO SAN RAFFAELE
    Inventors: Nathanael S. Gray, Sara Buhrlage, Kenneth Anderson, Francesca Cottini, Giovanni Tonon
  • Targets in multiple myeloma and other disorders
    Patent number: 10017767
    Abstract: An agent that increases YAP1 levels for use in the treatment of hematopoietic disorders.
    Type: Grant
    Filed: November 5, 2013
    Date of Patent: July 10, 2018
    Assignees: FONDAZIONE CENTRO SAN RAFFAELE, DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Giovanni Tonon, Francesca Cottini, Kenneth Carl Anderson
  • STK4 INHIBITORS FOR TREATMENT OF HEMATOLOGIC MALIGNANCIES
    Publication number: 20180111916
    Abstract: The application relates to compounds of Formula (I?): which modulate the activity of a kinase (e.g., STK4), a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease or disorder associated with the modulation of a kinase, such as STK4.
    Type: Application
    Filed: March 31, 2016
    Publication date: April 26, 2018
    Inventors: Nathanael S. GRAY, Sara BUHRLAGE, Kenneth ANDERSON, Francesca COTTINI, Giovanni TONON
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
    Patent number: 9309564
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
    Type: Grant
    Filed: May 17, 2012
    Date of Patent: April 12, 2016
    Assignees: Dana-Farber Cancer Institute, Inc., Board of Trustees of the University of Arkansas
    Inventors: Ronald A. DePinho, Kenneth C. Anderson, Ruben D. Carrasco, Giovanni Tonon, Cameron Brennan, John D. Shaughnessy, Jr., Lynda Chin
  • NOVEL TARGETS IN MULTIPLE MYELOMA AND OTHER DISORDERS
    Publication number: 20150252368
    Abstract: An agent that increases YAP1 levels for use in the treatment of hematopoietic disorders.
    Type: Application
    Filed: November 5, 2013
    Publication date: September 10, 2015
    Inventors: Giovanni Tonon, Francesca Cottini, Kenneth Carl Anderson
  • Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Cancer
    Publication number: 20130072392
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
    Type: Application
    Filed: May 17, 2012
    Publication date: March 21, 2013
    Applicants: Board of Trustees of the University of Arkansas, Dana-Farber Cancer Institute, Inc.
    Inventors: Ronald A. DePinho, Kenneth C. Anderson, Ruben D. Carrasco, Giovanni Tonon, Cameron Brennan, John D. Shaughnessy, JR., Lynda Chin
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of cancer
    Patent number: 8211634
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
    Type: Grant
    Filed: February 13, 2007
    Date of Patent: July 3, 2012
    Assignees: Dana-Farber Cancer Institute, Inc., Board of Trustees of the University of Arkansas
    Inventors: Ronald A. DePinho, Kenneth C. Anderson, Ruben D. Carrasco, Giovanni Tonon, Cameron W. Brennan, John D. Shaughnessy, Jr., Lynda Chin
  • Compositions, kits and methods for identification, assessment, prevention and therapy of cancer
    Patent number: 8168602
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: May 1, 2012
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Ronald A. DePinho, Giovanni Tonon, Kwok-Kin Wong, Lynda Chin
  • Compositions, kits and methods for identification, assessment, prevention and therapy of cancer
    Publication number: 20090297525
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
    Type: Application
    Filed: February 17, 2006
    Publication date: December 3, 2009
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Ronald A. Depinho, Giovanni Tonon, Kwok-kin Wong, Lynda Chin
  • Compostions, kits, and methods for identification, assessment, prevention, and therapy of cancer
    Publication number: 20080075722
    Abstract: The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or more of the MCRs and/or alterations in the amount, structure, and/or activity of one or more of the markers is correlated with the presence of cancer.
    Type: Application
    Filed: February 13, 2007
    Publication date: March 27, 2008
    Inventors: Ronald DePinho, Kenneth Anderson, Ruben Carresco, Giovanni Tonon, Cameron Brennan, John Shaughnessy, Lynda Chin
  • Detection of MECT1-MAML2 fusion products
    Patent number: 7214488
    Abstract: The present invention provides methods and compositions for the diagnosis and treatment of cancer, including cancers involving the NOTCH pathway. In particular, the present invention provides methods and compositions for the diagnosis of mucoepidermoid carcinoma, the most common malignant salivary gland tumor. The present invention further provides methods and compositions for the diagnosis of other tumors associated with the t(11;19)(q14–21;12–13) translocation.
    Type: Grant
    Filed: July 3, 2002
    Date of Patent: May 8, 2007
    Assignee: United States of America, Represented by the Secretary, Department of Health and Human Services
    Inventors: Frederic J. Kaye, Giovanni Tonon
  • Diagnosis and treatment of cancer involving the notch pathway
    Publication number: 20040180349
    Abstract: The present invention provides methods and compositions for the diagnosis and treatment of cancer, including cancers involving the NOTCH pathway. In particular, the present invention provides methods and compositions for the diagnosis of mucoepidermoid carcinoma, the most common malignant salivary gland tumor. The present invention further provides methods and compositions for the diagnosis of other tumors associated with the t(11;19)(q14-21;12-13) translocation.
    Type: Application
    Filed: March 29, 2004
    Publication date: September 16, 2004
    Inventors: Frederic J. Kaye, Giovanni Tonon