Patents by Inventor Giovanni Zocchi

Giovanni Zocchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Allosteric control of proteins by manipulating mechanical tension
    Patent number: 8460870
    Abstract: A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the mechanical tension of the polymer, thereby altering the conformation of the polypeptide. The alteration of the conformation of the polypeptide may increase or decrease the binding affinity of the polypeptide for a substrate bound by the polypeptide, or alter the catalytic rate of an enzyme. Typically, the polymer is a polynucleotide or polypeptide.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: June 11, 2013
    Assignee: The Regents of the University of California
    Inventors: Giovanni Zocchi, Brian Choi
  • ALLOSTERIC CONTROL OF PROTEINS BY MANIPULATING MECHANICAL TENSION
    Publication number: 20110275057
    Abstract: A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the mechanical tension of the polymer, thereby altering the conformation of the polypeptide. The alteration of the conformation of the polypeptide may increase or decrease the binding affinity of the polypeptide for a substrate bound by the polypeptide, or alter the catalytic rate of an enzyme. Typically, the polymer is a polynucleotide or polypeptide.
    Type: Application
    Filed: July 20, 2011
    Publication date: November 10, 2011
    Applicant: The Regents of the University of California
    Inventors: Giovanni Zocchi, Brian Choi
  • Allosteric control of proteins by manipulating mechanical tension
    Patent number: 8008053
    Abstract: A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the mechanical tension of the polymer, thereby altering the conformation of the polypeptide. The alteration of the conformation of the polypeptide may increase or decrease the binding affinity of the polypeptide for a substrate bound by the polypeptide, or alter the catalytic rate of an enzyme. Typically, the polymer is a polynucleotide or polypeptide.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: August 30, 2011
    Assignee: The Regents of the University of California
    Inventors: Giovanni Zocchi, Brian Choi
  • Allosteric Control of Proteins by Manipulating Mechanical Tension
    Publication number: 20080311592
    Abstract: A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the mechanical tension of the polymer, thereby altering the conformation of the polypeptide. The alteration of the conformation of the polypeptide may increase or decrease the binding affinity of the polypeptide for a substrate bound by the polypeptide, or alter the catalytic rate of an enzyme. Typically, the polymer is a polynucleotide or polypeptide.
    Type: Application
    Filed: January 20, 2006
    Publication date: December 18, 2008
    Applicant: The Regents of the University of California
    Inventors: Giovanni Zocchi, Brian Choi
  • Detection of polynucleotide hybridization
    Publication number: 20040241699
    Abstract: The invention disclosed herein provides a new detection scheme to monitor hybridization between complimentary polynucleotides such as DNA and/or RNA. Embodiments of the invention disclosed herein localized electromagnetic radiation to provide an optimized analysis of polynucleotide hybridization in contexts such as the polynucleotide microarrays typically used on gene chips.
    Type: Application
    Filed: April 1, 2004
    Publication date: December 2, 2004
    Inventors: Giovanni Zocchi, Mukta Singh Zocchi