Patents by Inventor Giridhar Murlidharan

Giridhar Murlidharan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS FOR AND METHODS OF IMPROVING FLUID FLUX IN THE BRAIN
    Publication number: 20240082351
    Abstract: The present disclosure provides compositions for and methods of preventing protein aggregation, removing protein aggregates, and improving fluid flux in the brain.
    Type: Application
    Filed: January 13, 2022
    Publication date: March 14, 2024
    Inventors: Aravind Asokan, Aaron Mitchell-Dick, Giridhar MURLIDHARAN, Ruth Castellanos Rivera
  • Methods and compositions for gene transfer across the vasculature
    Patent number: 11905312
    Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: February 20, 2024
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Giridhar Murlidharan, Blake Albright
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF TAUOPATHY
    Publication number: 20240000971
    Abstract: The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: November 3, 2021
    Publication date: January 4, 2024
    Inventors: Todd Carter, Wencheng Liu, Jerrah Holth, Jinzhao Hou, Yanqun Shu, Giridhar Murlidharan, Xiao-Qin Ren
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS RELATED TO GLUCOSYLCERAMIDASE BETA DEFICIENCY
    Publication number: 20230227802
    Abstract: The disclosure relates to compositions and methods for altering, e.g., enhancing, the expression of GCase proteins, whether in vitro and/or in vivo. Such compositions include delivery of an adeno-associated viral (AAV) particle. The compositions and methods of the present disclosure are useful in the treatment of subjects diagnosed with, or suspected of having Parkinson Disease or related condition resulting from a deficiency in the quantity and/or function of GBA gene product or associated with decreased expression or protein levels of GCase protein.
    Type: Application
    Filed: July 26, 2021
    Publication date: July 20, 2023
    Inventors: Giridhar MURLIDHARAN, Jeffrey BROWN, Elisabeth KNOLL, Yanqun SHU, Kelly BALES, Jinzhao HOU, Adewale ADELUYI, Brett HOFFMAN, Smita JAGTAP
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF TAUOPATHY
    Publication number: 20220339270
    Abstract: The disclosure provides compositions and methods for the preparation, manufacture and therapeutic use of viral vectors, such as adeno-associated virus (AAV) particles having viral genomes encoding one or more antibodies or antibody fragments or antibody-like polypeptides, for the prevention and/or treatment of diseases and/or disorders.
    Type: Application
    Filed: April 29, 2020
    Publication date: October 27, 2022
    Applicant: Voyager Therapeutics, Inc.
    Inventors: Wencheng Liu, Todd Carter, Jinzhao Hou, Yanqun Shu, Giridhar Murlidharan, Martin Goulet, Dinah Wen-Yee Sah, Steven Paul, Xiao-Qin Ren, Xin Wang, Hiu Yan Chung
  • COMPOSITIONS AND METHODS FOR DELIVERY OF AAV
    Publication number: 20210371470
    Abstract: The disclosure provides compositions and methods for the preparation, manufacture, formulation and therapeutic use of adeno-associated virus (AAV) particles for the prevention and/or treatment of diseases.
    Type: Application
    Filed: October 11, 2019
    Publication date: December 2, 2021
    Inventors: Giridhar Murlidharan, Dinah Wen-Yee Sah, Holger Patzke, Todd Carter, Jinzhao Hou, Kei Adachi, Amy Ren
  • COMPOSITIONS AND METHODS FOR DELIVERY OF AAV
    Publication number: 20210230632
    Abstract: The disclosure provides compositions and methods for the preparation, manufacture, formulation and therapeutic use of adeno-associated virus (AAV) particles for the prevention and/or treatment of diseases.
    Type: Application
    Filed: May 15, 2019
    Publication date: July 29, 2021
    Inventors: Dinah Wen-Yee Sah, Holger Patzke, Todd Carter, Jinzhao Hou, Giridhar Murlidharan
  • Methods and compositions for targeted gene transfer
    Patent number: 10907176
    Abstract: The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: February 2, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Aravind Asokan, Giridhar Murlidharan, Shen Shen
  • METHODS AND COMPOSITIONS FOR GENE TRANSFER ACROSS THE VASCULATURE
    Publication number: 20190367562
    Abstract: The present disclosure provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The disclosure also provides methods of administering the virus vectors and virus capsids of the disclosure to a cell or to a subject in vivo.
    Type: Application
    Filed: February 15, 2018
    Publication date: December 5, 2019
    Inventors: Aravind Asokan, Giridhar Murlidharan, Blake Albright
  • METHODS AND COMPOSITIONS FOR TARGETED GENE TRANSFER
    Publication number: 20180002722
    Abstract: The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus capsids and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
    Type: Application
    Filed: January 14, 2016
    Publication date: January 4, 2018
    Inventors: Aravind Asokan, Giridhar Murlidharan, Shen Shen