Abstract: Solid dispersions of lurasidone or a pharmaceutically acceptable salt thereof are described, as well as pharmaceutical formulations thereof, and methods for making such formulations. Preferably, the solid dispersions are prepared by hot-melt extrusion or spray-drying, and comprise lurasidone with a pharmaceutically acceptable carrier (e.g., hydroxypropyl methyl cellulose acetate succinate (HPMC-AS), polyvinyl pyrrolidine vinyl acetate (PVP/VA) copolymer, hydroxypropyl methylcellulose phthalate (HPMCP), or mixtures thereof). The pharmaceutical composition may be orally administered to a patient in either the fed or fasted state, with a decrease or elimination of the food effect. Preferably, following oral administration of the pharmaceutical compositions, there is no substantial difference in the pharmacokinetic parameters (e.g., Tmax, Cmax, AUC0-t and/or AUC0-infinity) of lurasidone, regardless of whether the pharmaceutical compositions are administered to a subject in the fed or fasted state.

Abstract: Solid dispersions of lurasidone or a pharmaceutically acceptable salt thereof are described, as well as pharmaceutical formulations thereof, and methods for making such formulations. Preferably, the solid dispersions are prepared by hot-melt extrusion or spray-drying, and comprise lurasidone with a pharmaceutically acceptable carrier (e.g., hydroxypropyl methyl cellulose acetate succinate (HPMC-AS), polyvinyl pyrrolidine vinyl acetate (PVP/VA) copolymer, hydroxypropyl methylcellulose phthalate (HPMCP), or mixtures thereof). The pharmaceutical composition may be orally administered to a patient in either the fed or fasted state, with a decrease or elimination of the food effect. Preferably, following oral administration of the pharmaceutical compositions, there is no substantial difference in the pharmacokinetic parameters (e.g., Tmax, Cmax, AUC0-t and/or AUC0-infinity) of lurasidone, regardless of whether the pharmaceutical compositions are administered to a subject in the fed or fasted state.

Abstract: Delayed-release pharmaceutical compositions prepared by hot-melt extrusion are provided, where the compositions comprise an azole anti-fungal drug having poor water solubility, an enteric polymer and a non-enteric polymer, and wherein the pharmaceutical composition may be orally administered to a patient in either the fed or fasted state. Preferably, the delayed-release pharmaceutical compositions prepared by hot-melt extrusion comprise posaconazole, HPMC-AS and HPC. Preferably, following oral administration of the pharmaceutical compositions, there is no substantial difference in the pharmacokinetic parameters (Tmax, Cmax, AUC0-t and/or AUC0-infinity) of the azole anti-fungal drug, regardless of whether the pharmaceutical compositions are administered to a subject in the fed or fasted state.

Abstract: A subject support (14) is configured to dock with a medical imaging device (50) with a fixed spatial relationship between the docked subject support and the medical imaging device. A patient positioning device includes a range camera (10) that acquires a two-dimensional (2D) range image of a human imaging subject (12) disposed on a subject support (14). The range image has pixel values corresponding to distances from the range camera. An electronic processor (16) is programmed to perform a positioning method to determine a reference point on or in the human subject in a frame of reference (FS) of the subject support from the 2D range image. This reference point is translated to a frame of reference (FD) of the imaging device based on a priori known spatial relationship of the medical imaging device and the docked subject support. Using 3D models, the loading process may be simulated.

Abstract: Techniques are described herein for providing highly available and scalable cloud services. In one or more embodiments, a network service receives from a first client of a plurality of clients, a request to lease a first slice of a plurality of slices of a workload. In response, the network services assigning, to the first client, a lease for the first slice, wherein the lease expires after a lease duration. The network service then receives, from a second client of the plurality of clients, a request to lease the first slice. Based on a state associated with the first client after the lease duration, the network service reassigns the lease for the first slice to the second client. The second client processes a subset of workflow executions associated with the first slice that have not previously been processed by the first client.

Abstract: In addition to caching I/O operations at a host, at least some data management can migrate to the host. With host side caching, data sharing or deduplication can be implemented with the cached writes before those writes are supplied to front end storage elements. When a host cache flush to distributed storage trigger is detected, the host deduplicates the cached writes. The host aggregates data based on the deduplication into a “change set file” (i.e., a file that includes the aggregation of unique data from the cached writes). The host supplies the change set file to the distributed storage system. The host then sends commands to the distributed storage system. Each of the commands identifies a part of the change set file to be used for a target of the cached writes.

Abstract: Embodiments relate to dynamically defining and visually representing worker threads. More specifically, a set of parameters is defined for each of multiple worker threads, and a dot-matrix UI represents characteristics of individual parameter across worker threads to facilitate expedient configuration.

Abstract: A method for codeless development of an application includes registering one or more actions in a registry. Each action is coded in a reusable block of code, each action having an action definition including an action type name, an input parameters map, and an output parameters map. The method further includes performing an action type name look up in the registry for an invoked action with an action service ensuring that a number of arguments included in the action definition matches a number of arguments specified by the action type, passing an input to and receiving a return value from the invoked action, updating the output parameters map included in the definition of the invoked action, and returning the updated output parameters map to an application in development for updating processing variables in the application.

Abstract: Embodiments relate to dynamically defining and visually representing worker threads.

Abstract: In one embodiment, a method includes receiving a search query input comprising one or more n-grams; parsing the search query input to identify keywords; generating query commands for the keywords. Each query command may specify: a particular object-type; one or more identifiers of one or more objects that match the search query input; and one or more types of relationships with respect to the objects. The method may further include searching a particular vertical that stores objects of the particular object-type having a relationship of the type of relationship with respect to one or more of the objects; generating a plurality of search-result modules corresponding to the query commands, each search-result module comprising references to objects of the particular object-type specified by the query command; and sending, to a client device, instructions for presenting an interface comprising one or more of the search-result modules.

Abstract: Systems and methods for selectively enforcing business logic on a plurality of applications have been provided. The system architecture may include one or more systems of record and a plurality of applications running on a plurality of client machines. A smart factory may store customer data and associated logic obtained from a system of record. The logic may include rules governing use of the customer data in an application user interface. The smart factory may transmit the rules to the plurality of applications. Each application may include an application integrator configured to receive the rules and execute an update to enforce the rules on an application user interface. In addition, the smart factory customer data may be accessed by the applications to prevent repeated calls to the systems of record for commonly used information.

Abstract: Systems and methods for selectively enforcing business logic on a plurality of applications have been provided. The system architecture may include one or more systems of record and a plurality of applications running on a plurality of client machines. A smart factory may store customer data and associated logic obtained from a system of record. The logic may include rules governing use of the customer data in an application user interface. The smart factory may transmit the rules to the plurality of applications. Each application may include an application integrator configured to receive the rules and execute an update to enforce the rules on an application user interface. In addition, the smart factory customer data may be accessed by the applications to prevent repeated calls to the systems of record for commonly used information.

Abstract: In one general aspect, a method can include creating an action, the creating including annotating a block of code with metadata, and encapsulating the annotated block of code into a reusable building block of code. The method can further include publishing the action, the publishing including registering the action in a service registry. The method can further include dynamically discovering the action in the service registry by an application during runtime, invoking the action by the application, and executing the action by the application, the executing performing a method specified by the action.

Abstract: In addition to caching I/O operations at a host, at least some data management can migrate to the host. With host side caching, data sharing or deduplication can be implemented with the cached writes before those writes are supplied to front end storage elements. When a host cache flush to distributed storage trigger is detected, the host deduplicates the cached writes. The host aggregates data based on the deduplication into a “change set file” (i.e., a file that includes the aggregation of unique data from the cached writes). The host supplies the change set file to the distributed storage system. The host then sends commands to the distributed storage system. Each of the commands identifies a part of the change set file to be used for a target of the cached writes.

Abstract: A new approach is proposed to support monitoring Perfect Forward Secrecy (PFS) network traffic by utilizing a hardware security module (HSM) appliance. Here, the HSM appliance is a high-performance, Federal Information Processing Standards (FIPS) 140-compliant security hardware with embedded firmware, which can be used for management and sharing of ephemeral keys used in a secured PFS communication session between two parties. Specifically, the HSM allows a server to share one or more of its ephemeral keys and/or parameters used in PFS traffic during the session with a third party under specified access rights and/or authorization, wherein the third party can be but is not limited to a traffic monitoring module. The HSM allows the third party to access the ephemeral keys stored on the HSM under the specified access rights and/or authorization so that the third party may decrypt and run analytics on the PFS traffic captured during the session.

Abstract: Systems and methods for selectively enforcing business logic on a plurality of applications have been provided. The system architecture may include one or more systems of record and a plurality of applications running on a plurality of client machines. A smart factory may store customer data and associated logic obtained from a system of record. The logic may include rules governing use of the customer data in an application user interface. The smart factory may transmit the rules to the plurality of applications. Each application may include an application integrator configured to receive the rules and execute an update to enforce the rules on an application user interface. In addition, the smart factory customer data may be accessed by the applications to prevent repeated calls to the systems of record for commonly used information.

Abstract: Disclosed is a method and a system for extracting entity information from target data. The method comprises: providing the target data; refining the target data to obtain at least one base entity information having a plurality of base entity units using an algorithm, wherein the algorithm is based on a predefined syntax; generating a plurality of strings for each of the base entity information, wherein the plurality of strings comprises at least one base entity unit among the plurality of base entity units; sorting the plurality of strings in a decreasing order of length of the plurality of strings; identifying an entity type of the plurality of strings, based on an ontology, by processing the plurality of strings sequentially; assigning labels to the plurality of strings based on the entity type; and mapping the labelled plurality of strings to a predefined signature to obtain the entity information.

Abstract: Exemplary embodiments relate to techniques that allow for file system support to be rapidly deployed for new or updated operating system distributions. In some embodiments, a management component is provided perform data management on file systems. When a data management operation on a file system is requested, an operation component searches in a predetermined location for a named module that implements certain types of operations. The operation component then calls these operations (including validate, build and deport operations for the file system) to implement data management procedures in the file system. Implementing support for a new operating system or file system does not require that the management entity be rebuilt. Upon release of a new operating system or file system, a new named module can be written and placed in the predetermined location where the operation module is configured to search.

Abstract: The present invention relates to bioactive fractions and compounds from Dalbergia sissoo for the prevention or treatment of osteo-health related disorders. The present invention relates in the field of pharmaceutical composition that provides new plant extracts, their fractions and pure compound isolated from natural sources that are useful for the prevention and/or treatment of various medical indications associated with estrogen dependent or independent diseases or syndromes or disorders preferably in the prevention or treatment of estrogen dependent or independent diseases or syndromes or disorders caused in humans and animals, and achievement of peak bone mass during skeletal growth and health in humans and animals.

Abstract: Implementations described herein generally relate to metal electrodes, more specifically lithium-containing anodes, high performance electrochemical devices, such as secondary batteries, including the aforementioned lithium-containing electrodes, and methods for fabricating the same. In one implementation, an anode electrode structure is provided. The anode electrode structure comprises a current collector comprising copper. The anode electrode structure further comprises a lithium metal film formed on the current collector. The anode electrode structure further comprises a solid electrolyte interface (SEI) film stack formed on the lithium metal film. The SEI film stack comprises a chalcogenide film formed on the lithium metal film. In one implementation, the SEI film stack further comprises a lithium oxide film formed on the chalcogenide film. In one implementation, the SEI film stack further comprises a lithium carbonate film formed on the lithium oxide film.