Abstract: A system includes an inner filling structure around a stent-structure and an outer filling structure around the inner filling structure. The inner filling structure can be configured to produce a proximal seal with a first portion of an artery at a proximal end and a distal seal with a second portion of an artery at a distal end when the inner filling structure is in an inflacted state. The outer filling structure can have an inner surface surrounding at least a portion of the inner filling structure. The outer filling structure can be configured to be inflatable to occupy a space within an aneurysm at a lower pressure than a pressure in the inner filling structure.

Abstract: A system includes a graft body and a filling structure. The graft body has a fenestration in a side surface through which a support structure is insertable. The filling structure has an internal volume that is tillable with a filling medium and is configured to have a conduit through the internal volume through which the support structure is insertable. The conduit in the filling structure is alignable with the fenestration in the graft body such that the support structure is insertable through both the conduit in the filling structure and the fenestration in the graft body.

Abstract: A system includes an inner filling structure around a stent-structure and an outer filling structure around the inner filling structure. The inner filling structure can be configured to produce a proximal seal with a first portion of an artery at a proximal end and a distal seal with a second portion of an artery at a distal end when the inner filling structure is in an inflacted state. The outer filling structure can have an inner surface surrounding at least a portion of the inner filling strucutre. The outer filling structure can be configured to be inflatable to occupy a space within an aneurysm at a lower pressure than a pressure in the inner filling structure.

Abstract: A dilatation catheter includes an inflation balloon having a variable diameter inflation profile. The balloon has a first inflation profile, in which it exhibits a substantially cylindrical central working profile. The first inflation profile of the balloon is achieved by inflating the balloon to a first inflation pressure. The balloon has a second inflation profile which is achieved by increasing the inflation pressure to a second, higher pressure. In the second inflation profile, a proximal segment and a distal segment of the balloon have a first inflated diameter and a central focal segment, separating the proximal and distal segments, has a second inflated diameter, such that the second inflated diameter is greater than the first inflated diameter.

Abstract: A catheter comprising an elongated, flexible catheter body having a distal end portion which is curved in an unstressed condition. The catheter body has a through lumen and a mandrel lumen. A mandrel is provided in the mandrel lumen, and the mandrel has a distal end portion configured to at least partially straighten the curve of the distal end portion of the catheter body. The mandrel is movable between an extended position in which the mandrel at least partially straightens the curve of the distal end portion of the catheter body and a retracted position in which the catheter body is more curved than in the extended position of the mandrel.