Abstract: A system and method are provided for determining cleaning schedules for equipment. The equipment includes fired heaters and/or heat exchangers. The method includes obtaining historical sensor data; transforming the obtained sensor data using an engineering first principles process; applying data analytics to the transformed data to generate at least one statistical model; predicting an indicator of fouling in the equipment using operating data and the at least one statistical model; obtaining cost data associated with the equipment being analyzed; determining from the prediction and cost data a desired cleaning schedule for the equipment; and providing an output associated with the desired cleaning schedule.