Abstract: Described herein is malarial immnunogen or a variant thereof comprising at least a portion of the wild-type PfCSP amino acid sequence lacking a KQ motif. In aspects, the malarial immunogen is lacking a KQP motif. For example, the immnunogens described herein, in aspects, exclude the C-terminal domain of PfCSP. In other aspects, the immunogens described herein specifically exclude a KQ or KQP motif. In aspects the immunogens described herein exclude an N-terminal KQ or KQP motif, which is part of the N-terminal junction region in PfCSP.

Abstract: Described herein is an immunogenic fusion protein comprising: an immunogenic peptide or an immunogenic variant thereof, the immunogenic peptide comprising the following motifs: —KQPAa; QPAKa; PAKQa; or AKQPa; —NPDPb; PNPDb; DPNPb; or PNPDb; —NANPc; ANPNc; NPNAc; or PNANc; —NVDPd; VDPNd; DPNVd; or PNVDd; and —NANPe; ANPNe; NPNAe; or PNANe. wherein a, b, c, d, and e are each independently 0 or greater and wherein a±b±c±d±e is at least 2; and a nanocage monomer peptide.

Abstract: The present invention relates to an antibody binding to a peptide comprising an amino acid sequence NANP (SEQ ID NO:1) and to at least one peptide comprising an amino acid sequence selected from NVDP (SEQ ID NO:2), NPDP (SEQ ID NO:3), and KQPA (SEQ ID NO:4), to a polynucleotide or polynucleotides encoding said antibody, and to said antibody for use in medicine and for use in prevention of Plasmodium infection. Moreover, the present invention relates to methods, kits, and devices related thereto.

Abstract: A system for waking a user up by a stimulus, wherein the stimulus is adapted to vary according to an intensity curve. A user interface is adapted to receive user preferences, such as a desired wake-up time and a preference indicator. The preference indicator indicates whether the user prefers to be more alert after waking up or to have a longer sleep. An alarm is used for providing a stimulus to the user and a processor is used for determining a stimulus intensity curve for the alarm. Determining the stimulus intensity curve is based on at least the user preferences.

Abstract: A system is provided for waking a user up by a stimulus, wherein the stimulus is adapted to vary according to an intensity curve. A user interface is adapted to receive user preferences, such as a desired wake-up time and a preference indicator. The preference indicator indicates whether the user prefers to be more alert after waking up or to have a longer sleep. An alarm is used for providing a stimulus to the user and a processor is used for determining a stimulus intensity curve for the alarm. Determining the stimulus intensity curve is based on at least the user preferences.