Patents by Inventor Giulia Fulci

Giulia Fulci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS RELATING TO THE TREATMENT OF TUMORS
    Publication number: 20250082723
    Abstract: Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiments, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.
    Type: Application
    Filed: November 20, 2024
    Publication date: March 13, 2025
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary J. BRENNER, Giulia FULCI, Sherif AHMED
  • Methods and compositions relating to the treatment of tumors
    Patent number: 12178845
    Abstract: Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiment, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: December 31, 2024
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary J. Brenner, Giulia Fulci, Sherif Ahmed
  • METHODS AND COMPOSITIONS RELATING THE TREATMENT OF TUMORS
    Publication number: 20190336577
    Abstract: Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiment, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.
    Type: Application
    Filed: December 6, 2017
    Publication date: November 7, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary J. BRENNER, Giulia FULCI, Sherif AHMED
  • AAV1-caspase gene therapy induced pyroptosis for the treatment of tumors
    Patent number: 9644215
    Abstract: Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: May 9, 2017
    Assignee: The General Hospital Corporation
    Inventors: Gary J. Brenner, Xandra O. Breakefield, Giulia Fulci
  • GENE THERAPY INDUCED PYROPTOSIS FOR THE TREATMENT OF TUMORS
    Publication number: 20140309288
    Abstract: Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter.
    Type: Application
    Filed: January 30, 2014
    Publication date: October 16, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary J. Brenner, Xandra O. Breakefield, Giulia Fulci