Patents by Inventor Giuliano Elia

Giuliano Elia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of treating inflammatory and viral disorders by administering cyclopentenone compounds
    Publication number: 20050020687
    Abstract: The present invention relates to methods and compositions for the treatment and/or prevention of diseases and disorders in humans, including cancer, inflammatory diseases or disorders, and infectious diseases. In particular, the present invention relates to methods and compositions comprising the administration of a cyclopentenone prostaglandin or a derivative thereof, which induces cytoprotective responses and inhibits NF-?B activation. The present invention further relates to pharmaceutical compositions containing cyclopentenone prostaglandins for the treatment and/or prevention of viral infection, inflammation, and/or cancer in humans.
    Type: Application
    Filed: December 19, 2003
    Publication date: January 27, 2005
    Inventors: Maria Santoro, Antonio Rossi, Giuliano Elia, Enrico Garaci, Carla Amici
  • 2-cyclopenten-1-one and its derivatives as inhibitors of the NF-kB factor
    Patent number: 6696498
    Abstract: 2-Cyclopenten-1-one and its derivatives comprising the cyclopentenone nucleus as inhibitors of the NF-kB factor, with anti-inflammatory, anti-proliferative-immuno-suppressive, cytoprotective and antiviral activity, the substituents being selected among the ones which do not affect NF-kB inhibitory activity.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: February 24, 2004
    Assignee: Consiglio Nazionale Della Richerche
    Inventors: Maria Gabriella Santoro, Antonio Rossi, Giuliano Elia
  • 2-cyclopenten-1-one and its derivatives as inhibitors of the NF-kB factor
    Publication number: 20020137800
    Abstract: 2-Cyclopenten-1-one and its derivatives comprising the cyclopentenone nucleus as inhibitors of the NF-kB factor, with anti-inflammatory, anti-proliferative, immunosuppressive, cytoprotective and antiviral activity, the substituents being selected among the ones which do not affect the NF-kB inhibitory activity.
    Type: Application
    Filed: May 10, 2002
    Publication date: September 26, 2002
    Applicant: Consiglio Nazionale Della Richere
    Inventors: Maria Gabriella Santoro, Antonio Rossi, Giuliano Elia
  • 2-Cyclopenten-1-one as inhibitors of the NF-KB factor
    Patent number: 6392100
    Abstract: 2-Cyclopenten-1-one and its derivatives comprising the cyclopentenone nucleus as inhibitors of the NF-kB factor, with anti-inflammatory, anti-proliferative, immunosuppressive, cytoprotective and antiviral activity, the substituents being selected among the ones which do not affect the NF-kB inhibitory activity. Further the cyclopentenone derivative is a cyclopentenone compound which does not have two adjacent aliphatic side chains or a prostaglandin.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: May 21, 2002
    Assignee: Consiglio Nazionale Delle Richerche
    Inventors: Maria Gabriella Santoro, Antonio Rossi, Giuliano Elia
  • 2-cyclopenten-1-one as an inducer of HSP70
    Patent number: 6180681
    Abstract: The invention relates to 2-cyclopenten-1-one as an inducer of the heat shock protein HSP70 by activating the heat shock transcription factor HSF, and selectively inducing the transcription and translation of HSP70 in human cells. In particular, since a cytoprotective role of HSP70 during viral infection was previously shown, the invention refers to 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives as inducers of HSP70 with antiviral activity. Treatment with 2-cyclopenten-1-one and its pharmaceutically acceptable derivatives causes a dose-dependent reduction of infectious virus yield during infection with vesicular stomatitis virus. The block of virus replication is due to inhibition of viral protein synthesis, associated with HSP70 synthesis.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: January 30, 2001
    Assignee: Consiglio Nazionale Delle Ricerche
    Inventors: Carla Amici, Giuliano Elia, Enrico Garaci, Antonio Rossi, Maria Gabriella Santoro