Patents by Inventor Giulio Alighieri

Giulio Alighieri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trans-activated functional RNA by strand displacement and uses thereof
    Patent number: 11834659
    Abstract: The present disclosure, at least in part, relates to an engineered RNA (e.g., microRNA and sgRNA), in the absence of an input signal, that is engineered to have a large enough energy gap between the formations of a first secondary structure, which is unrecognizable by an actuator, and a second secondary structure, which is recognizable by an actuator (e.g., Drosha and Cas protein).
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: December 5, 2023
    Assignee: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Giulio Alighieri
  • MICRORNA-BASED LOGIC GATES AND USES THEREOF
    Publication number: 20230124274
    Abstract: The present disclosure, at least in part, relates to a miRNA based logic gate that comprises an engineered RNA carrier that comprises an nuclear export signal, a target site for a first miRNA and a pre-miRNA sequence for a second miRNA. Also provided by the disclosure are recombinant viruses (e.g., recombinant adeno-associated viruses (rAAV)) for delivery of the miRNA based logic gates.
    Type: Application
    Filed: November 1, 2022
    Publication date: April 20, 2023
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Giulio Alighieri
  • MicroRNA-based logic gates and uses thereof
    Patent number: 11492622
    Abstract: The present disclosure, at least in part, relates to a miRNA based logic gate that comprises an engineered RNA carrier that comprises an nuclear export signal, a target site for a first miRNA and a pre-miRNA sequence for a second miRNA. Also provided by the disclosure are recombinant viruses (e.g., recombinant adeno-associated viruses (rAAV)) for delivery of the miRNA based logic gates.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: November 8, 2022
    Assignee: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Giulio Alighieri
  • TRANS-ACTIVATED FUNCTIONAL RNA BY STRAND DISPLACEMENT AND USES THEREOF
    Publication number: 20210395732
    Abstract: The present disclosure, at least in part, relates to an engineered RNA (e.g., microRNA and sgRNA), in the absence of an input signal, that is engineered to have a large enough energy gap between the formations of a first secondary structure, which is unrecognizable by an actuator, and a second secondary structure, which is recognizable by an actuator (e.g., Drosha and Cas protein).
    Type: Application
    Filed: September 25, 2020
    Publication date: December 23, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Giulio Alighieri
  • MICRORNA-BASED LOGIC GATES AND USES THEREOF
    Publication number: 20210095287
    Abstract: The present disclosure, at least in part, relates to a miRNA based logic gate that comprises an engineered RNA carrier that comprises an nuclear export signal, a target site for a first miRNA and a pre-miRNA sequence for a second miRNA. Also provided by the disclosure are recombinant viruses (e.g., recombinant adeno-associated viruses (rAAV)) for delivery of the miRNA based logic gates.
    Type: Application
    Filed: September 25, 2020
    Publication date: April 1, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Giulio Alighieri
  • TRANS-ACTIVATED FUNCTIONAL RNA BY STRAND DISPLACEMENT AND USES THEREOF
    Publication number: 20210095286
    Abstract: The present disclosure, at least in part, relates to an engineered RNA (e.g., microRNA and sgRNA), in the absence of an input signal, that is engineered to have a large enough energy gap between the formations of a first secondary structure, which is unrecognizable by an actuator, and a second secondary structure, which is recognizable by an actuator (e.g., Drosha and Cas protein).
    Type: Application
    Filed: September 25, 2020
    Publication date: April 1, 2021
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Giulio Alighieri