Patents by Inventor Giulio Genovese
Giulio Genovese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230290467Abstract: The invention features methods that are useful for treatment of a patient at increased risk for infection and for selecting a patient for treatment for an infection. In various embodiments, the infection is coronavirus disease 2019 (COVID-19), sepsis, or other respiratory infections.Type: ApplicationFiled: March 14, 2023Publication date: September 14, 2023Applicants: The Broad Institute, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Servic, Yale University, The General Hospital CorporationInventors: Pradeep NATARAJAN, Giulio GENOVESE, Seyedeh Maryam ZEKAVAT, Mitchell J. MACHIELA, Shu-Hong LIN
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Patent number: 11613786Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.Type: GrantFiled: April 24, 2020Date of Patent: March 28, 2023Assignees: President and Fellows of Harvard College, The Broad Institute, Inc.Inventors: Steven A. McCarroll, Giulio Genovese
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Publication number: 20210123105Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.Type: ApplicationFiled: April 24, 2020Publication date: April 29, 2021Inventors: Steven A. McCarroll, Giulio Genovese
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Publication number: 20200399702Abstract: Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject. The methods include detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. In a further embodiment, methods are disclosed for detecting resistance of a subject to a disease associated with Trypanosoma infection. The methods include detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. Also disclosed are methods for treating a subject infected with T brucei (such as T. brucei brucei, T b. rhodesiense, or T b. gambiense). The methods include administering a therapeutically effective amount of an APOL1 protein including a S342G substitution, an I384M substitution, and/or a deletion of N388 and Y389 to the subject.Type: ApplicationFiled: July 6, 2020Publication date: December 24, 2020Inventors: Giulio Genovese, David J. Friedman, Martin R. Pollak, Barry I. Freedman
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Publication number: 20200303036Abstract: Embodiments disclosed herein provide methods, systems, and computer program products that utilize long-range phase information to detect subtle chromosome imbalances in genotype data. Clonal expansions result from mutation followed by selective proliferation, and the embodiments disclosed herein may be used to somatic structural variant events (SVs) predictive or diagnostic of cancer and other diseases.Type: ApplicationFiled: October 17, 2018Publication date: September 24, 2020Inventors: Giulio Genovese, Po-Ru Loh, Steven McCarroll
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Patent number: 10683552Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.Type: GrantFiled: November 23, 2015Date of Patent: June 16, 2020Assignees: Presidents and Fellows of Harvard College, The Broad Institute, Inc.Inventors: Steven Andrew McCarroll, Giulio Genovese
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Publication number: 20180105880Abstract: Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject. The methods include detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. In a further embodiment, methods are disclosed for detecting resistance of a subject to a disease associated with Trypanosoma infection. The methods include detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. Also disclosed are methods for treating a subject infected with T. brucei (such as T. brucei brucei, T. b. rhodesiense, or T. b. gambiense). The methods include administering a therapeutically effective amount of an APOL1 protein including a S342G substitution, an I384M substitution, and/or a deletion of N388 and Y389 to the subject.Type: ApplicationFiled: November 27, 2017Publication date: April 19, 2018Inventors: Giulio Genovese, David J. Friedman, Martin R. Pollak, Barry I. Freedman
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Patent number: 9828637Abstract: Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject, e.g., by detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. In a further embodiment, methods are disclosed for detecting resistance of a subject to a disease associated with Trypanosoma infection, e.g., by detecting at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. Also disclosed are methods for treating a subject infected with T. brucei. The methods include administering a therapeutically effective amount of an APOL1 protein including a S342G substitution, an I384M substitution, and/or a deletion of N388 and Y389 to the subject.Type: GrantFiled: April 18, 2011Date of Patent: November 28, 2017Assignees: Wake Forest University Health Sciences, Beth Israel Deaconess Medical Center, Inc.Inventors: Giulio Genovese, David J. Friedman, Martin R. Pollak, Barry I. Freedman
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Publication number: 20170321284Abstract: The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention relates to methods for predicting the development of cancer based on the observation of specific genetic mutations in somatic cell clones, as well as to methods for treating or preventing cancer in a subject, in which clonal expansion of cells comprising specific modifications is observed.Type: ApplicationFiled: November 23, 2015Publication date: November 9, 2017Applicants: The Broad Institute Inc., President and Fellows of Harvard CollegeInventors: Steven Andrew McCarroll, Giulio Genovese
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Publication number: 20130079244Abstract: Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject, e.g., by detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. In a further embodiment, methods are disclosed for detecting resistance of a subject to a disease associated with Trypanosoma infection, e.g., by detecting at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. Also disclosed are methods for treating a subject infected with T. brucei. The methods include administering a therapeutically effective amount of an APOL1 protein including a S342G substitution, an I384M substitution, and/or a deletion of N388 and Y389 to the subject.Type: ApplicationFiled: April 18, 2011Publication date: March 28, 2013Inventors: Giulio Genovese, David J. Friedman, Martin R. Pollak