Patents by Inventor Giuseppe Astarita

Giuseppe Astarita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230013977
    Abstract: The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture. This method relies on first selectively reacting one or more component in a sample with a chemical tag having two or more sites for ionization, followed by separation of components based on charge status, and finally characterization of each component to identify the same. Additionally disclosed are compounds useful as chemical tags in the disclosed methods.
    Type: Application
    Filed: August 30, 2022
    Publication date: January 19, 2023
    Applicant: Waters Technologies Corporation
    Inventors: Giuseppe Astarita, Darryl W. Brousmiche
  • Patent number: 11460438
    Abstract: The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture. This method relies on first selectively reacting one or more component in a sample with a chemical tag having two or more sites for ionization, followed by separation of components based on charge status, and finally characterization of each component to identify the same. Additionally disclosed are compounds useful as chemical tags in the disclosed methods.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 4, 2022
    Assignee: Waters Technologies Corporation
    Inventors: Giuseppe Astarita, Darryl W. Brousmiche
  • Patent number: 11333628
    Abstract: The present disclosure generally relates to methods for determining chemical class compositions present in a sample using collision cross-section fragment ion values.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: May 17, 2022
    Assignee: Waters Technologies Corporation
    Inventors: Giuseppe Astarita, Scott Geromanos
  • Patent number: 11237154
    Abstract: The present disclosure relates to methods and apparatus for identifying metabolic pathways and metabolites in complex biological samples. In particular, the present disclosure relates to a method and apparatus to increase the confidence of metabolite identification in metabolomics, such as in untargeted metabolomics data, using various statistical tools, such as over representation and enrichment analysis.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: February 1, 2022
    Assignee: Waters Technologies Corporation
    Inventor: Giuseppe Astarita
  • Publication number: 20220025065
    Abstract: Certain embodiments provide a method of detecting one or more biomarkers in a subject having a lysosomal storage disorder, the method comprising: 1) measuring the concentration of a combination of two or more lipids in a sample from the subject, wherein the combination of lipids is selected from the group consisting of: a) a bis(monoacylglycero)phosphate (BMP); b) a GM2 ganglioside and/or a GM3 ganglioside; c) a GD3 ganglioside; d) a GD1a/b ganglioside; and e) a glucosylceramide (GlcCer); 2) measuring the concentration of GlcCer in a sample from the subject; 3) measuring the concentration of neurofilament light chain (Nf-L) in a sample from the subject; and/or 4) measuring the concentration of soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in a sample from the subject.
    Type: Application
    Filed: December 10, 2019
    Publication date: January 27, 2022
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Annie ARGUELLO, Giuseppe ASTARITA, Akhil BHALLA, Jessica R. BLUMENFELD, Gilbert DI PAOLO, Anastasia HENRY, Alicia A. NUGENT, Julie ULLMAN, Junhua WANG
  • Publication number: 20220025039
    Abstract: Certain embodiments described herein provide a method for treating dysregulated lipid metabolism and/or inflammation in a mammal in need thereof, comprising administering to the mammal an effective amount of an agonist anti-triggering receptor expressed on myeloid cells 2 (TREM2) antibody.
    Type: Application
    Filed: November 26, 2019
    Publication date: January 27, 2022
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Giuseppe ASTARITA, Gilbert DI PAOLO, Kai Lin LIN, Kathryn M. MONROE, Alicia A. NUGENT, Bettina VAN LENGERICH
  • Publication number: 20210396772
    Abstract: The present disclosure provides methods and materials for screening a compound or monitoring a subjects response to a compound or dosing regimen for treating a PGRN-associated disorder. Methods and materials for identifying and treating a subject having a PGRN-associated disorder are also provided.
    Type: Application
    Filed: October 15, 2019
    Publication date: December 23, 2021
    Applicant: Denali Therapeutics Inc.
    Inventors: Giuseppe Astarita, Sarah L. Devos, Gilbert Di Paolo, Todd P. Logan, Junhua Wang
  • Publication number: 20210198640
    Abstract: Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.
    Type: Application
    Filed: November 23, 2020
    Publication date: July 1, 2021
    Applicant: Denali Therapeutics Inc.
    Inventors: Giuseppe Astarita, Mark S. Dennis, Jennifer A. Getz, Anastasia Henry, Mihalis Kariolis, Cathal Mahon, Adam P. Silverman, Ankita Srivastava, Julie Ullman, Junhua Wang, Joy Yu Zuchero
  • Publication number: 20200277584
    Abstract: Provided herein are fusion proteins that comprise an enzyme replacement therapy enzyme and an Fc region, as well as methods of using such proteins to treat a lysosomal storage disorder. Methods for transporting agents across the blood-brain barrier are also provided herein.
    Type: Application
    Filed: October 1, 2018
    Publication date: September 3, 2020
    Applicant: DENALI THERAPEUTICS INC.
    Inventors: Giuseppe ASTARITA, Mark S. DENNIS, Jennifer A. GETZ, Anastasia HENRY, Mihalis KARIOLIS, Cathal MAHON, Adam P. SILVERMAN, Ankita SRIVASTAVA, Julie ULLMAN, Junhua WANG, Joy Yu ZUCHERO
  • Publication number: 20200217855
    Abstract: The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture. This method relies on first selectively reacting one or more component in a sample with a chemical tag having two or more sites for ionization, followed by separation of components based on charge status, and finally characterization of each component to identify the same. Additionally disclosed are compounds useful as chemical tags in the disclosed methods.
    Type: Application
    Filed: February 17, 2017
    Publication date: July 9, 2020
    Applicant: Waters Technologies Corporation
    Inventors: Giuseppe Astarita, Darryl W. Brousmiche
  • Patent number: 10591448
    Abstract: The present disclosure relates to structural elucidation of isotopically labeled analytes using chromatography-MS and data-independent acquisition. The present disclosure can be used for rapid screening of analytes, such as the metabolome, including the simultaneous collection of both qualitative and quantitative information of known and unknown analytes.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: March 17, 2020
    Assignee: Waters Technologies Corporation
    Inventor: Giuseppe Astarita
  • Publication number: 20190317047
    Abstract: The present disclosure generally relates to methods for determining chemical class compositions present in a sample using collision cross-section fragment ion values.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 17, 2019
    Applicant: Waters Technologies Corporation
    Inventors: Giuseppe Astarita, Scott Geromanos
  • Patent number: 10410846
    Abstract: The present disclosure relates generally to methods and apparatus for determining components and associated conditions in a dermatological sample, and preparing personalized cosmetics or treatments. In particular, the present disclosure relates to the use of surface desorption ionization-mass spectrometry methods and apparatus to assay dermatological samples. The method and apparatus can allow real time analysis of sample molecules, such as in skin and hair, for molecular diagnostics in dermatology, dermatopathology and the preparation of personalized cosmetics.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: September 10, 2019
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventor: Giuseppe Astarita
  • Patent number: 10228361
    Abstract: The present disclosure relates generally to methods and apparatus for profiling the components and associated conditions in a dermatological sample, and preparing personalized cosmetics or treatments. In particular, the present disclosure relates to the use of surface desorption ionization-mass spectrometry apparatus and omics methodologies to profile or “fingerprint” dermatological samples, such as skin and hair samples, for personalized cosmetics. In particular, the method and apparatus can allow real time mass spectrometry-based lipidomics and metabolomics to phenotype skin and hair samples for molecular personalized cosmetics.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: March 12, 2019
    Assignee: Waters Technologies Corporation
    Inventor: Giuseppe Astarita
  • Publication number: 20180190479
    Abstract: The present disclosure relates generally to methods and apparatus for determining components and associated conditions in a dermatological sample, and preparing personalized cosmetics or treatments. In particular, the present disclosure relates to the use of surface desorption ionization-mass spectrometry methods and apparatus to assay dermatological samples. The method and apparatus can allow real time analysis of sample molecules, such as in skin and hair, for molecular diagnostics in dermatology, dermatopathology and the preparation of personalized cosmetics.
    Type: Application
    Filed: January 26, 2018
    Publication date: July 5, 2018
    Inventor: Giuseppe Astarita
  • Publication number: 20180164292
    Abstract: The present disclosure relates to methods and apparatus for identifying metabolic pathways and metabolites in complex biological samples. In particular, the present disclosure relates to a method and apparatus to increase the confidence of metabolite identification in metabolomics, such as in untargeted metabolomics data, using various statistical tools, such as over representation and enrichment analysis.
    Type: Application
    Filed: May 26, 2016
    Publication date: June 14, 2018
    Inventor: Giuseppe Astarita
  • Publication number: 20180143169
    Abstract: The present disclosure relates to structural elucidation of isotopically labeled analytes using chromatography-MS and data-independent acquisition. The present disclosure can be used for rapid screening of analytes, such as the metabolome, including the simultaneous collection of both qualitative and quantitative information of known and unknown analytes.
    Type: Application
    Filed: April 14, 2016
    Publication date: May 24, 2018
    Applicant: Waters Technologies Corporation
    Inventor: Giuseppe Astarita
  • Publication number: 20180128804
    Abstract: The present disclosure relates generally to methods and apparatus for determining essential nutrients and the ratio of essential nutrients in a sample. In particular, the present disclosure relates to the use of surface desorption ionization-mass spectrometry methods and apparatus to assay essential nutrients and ratios thereof, e.g., omega-6/omega-3 ratios.
    Type: Application
    Filed: May 26, 2016
    Publication date: May 10, 2018
    Inventors: Giuseppe Astarita, Donald Mason, Michael Balogh
  • Patent number: 9880147
    Abstract: The present disclosure relates to methods and apparatus for the determination of free fatty acids and total fatty acids in a sample. In particular, the present disclosure relates to the determination of free fatty acids and total fatty acids using desorption ionization-mass spectrometry. The methods and apparatus can include either in-source or post-ionization fragmentation of fatty acid containing compounds.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: January 30, 2018
    Assignee: Waters Technologies Corporation
    Inventors: Giuseppe Astarita, Donald Mason, Michael P. Balogh
  • Patent number: 9881777
    Abstract: The present disclosure relates generally to methods and apparatus for determining components and associated conditions in a dermatological sample, and preparing personalized cosmetics or treatments. In particular, the present disclosure relates to the use of surface desorption ionization-mass spectrometry methods and apparatus to assay dermatological samples. The method and apparatus can allow real time analysis of sample molecules, such as in skin and hair, for molecular diagnostics in dermatology, dermatopathology and the preparation of personalized cosmetics.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: January 30, 2018
    Assignee: Waters Technologies Corporation
    Inventor: Giuseppe Astarita