Abstract: The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.

Abstract: The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical compositions and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.

Abstract: Extraction method comprising an extraction step, during which a plant substrate is caused to come into contact with an aqueous liquid so that cannabinoids are extracted from the plant substrate and carried to the aqueous liquid; the aqueous liquid comprises at least 40% by weight, relative to the total weight of the aqueous liquid, of water and a complexing component; the complexing component is at least one cyclodextrin; the composition obtained is surprisingly stable and the cannabinoids extracted, in particular the acid cannabinoids, which are normally unstable, can be conserved for long periods of time.