Patents by Inventor Giuseppe Carlucci

Giuseppe Carlucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-INVASIVE PET IMAGING OF CDK4/6 ACTIVATION IN CANCER
    Publication number: 20210338670
    Abstract: Disclosed are compounds having the following structure: CDK-L-(X)n, where CDK is a CDK4/6 inhibitor group, L is a linking group, X is a radiolabel or hydrogen, n is 1, 2, 3, 4, or 5, and when there are a plurality of X groups, at least one X is a radiolabel. Also described are methods of making and using the compounds. The compounds may be used in PET imaging to quantify CDK4/6 expression in cancers and to treat cancer patients exhibiting tumors which express CDK4/6.
    Type: Application
    Filed: April 30, 2021
    Publication date: November 4, 2021
    Inventors: Giuseppe Carlucci, Thomas Reiner
  • Radiohalide-labeled targeted diagnostics and therapeutics
    Patent number: 10512700
    Abstract: Disclosed are chemical entities of formula (I) wherein R1, R2 and n are defined herein, and methods of use thereof. These chemical entities are radiative emitters and are useful, e.g., as therapeutic agents for the treatment of, or as diagnostic (e.g., imaging) agents for cancers, e.g., cancers in which PARP1 is overexpressed.
    Type: Grant
    Filed: August 27, 2015
    Date of Patent: December 24, 2019
    Assignee: Memorial Sloan Kettering Cancer Center
    Inventors: Thomas Reiner, Jason S. Lewis, Wolfgang Weber, Beatriz Salinas Rodriguez, Brandon Carney, Giuseppe Carlucci
  • RADIOHALIDE-LABELED TARGETED DIAGNOSTICS AND THERAPEUTICS
    Publication number: 20170266327
    Abstract: Disclosed are chemical entities of formula (I) wherein R1, R2 and n are defined herein, and methods of use thereof. These chemical entities are radiative emitters and are useful, e.g., as therapeutic agents for the treatment of, or as diagnostic (e.g., imaging) agents for cancers, e.g., cancers in which PARP1 is overexpressed.
    Type: Application
    Filed: August 27, 2015
    Publication date: September 21, 2017
    Inventors: Thomas Reiner, Jason S. Lewis, Wolfgang Weber, Beatriz Salinas Rodriguez, Brandon Carney, Giuseppe Carlucci