Publication number: 20040029917
Abstract: Compounds of formula (I) or a derivative thereof, wherein; R is C1-6allkyl, C3-7cycloalkyl, C1-6alkoxy, hydroxy, halo, C1-6alkenyl, C1-6allkynyl, amino, C1-6alkylamino, di(C1-6alkyl)amino, hydroxyC1-6alkyl, C1-6akoxyC1-6alkyl, aminoC1-6allkyl, (C1-6allkyl)aminoC1-6alkyl, di(C1-6allkyl)aminoC1-6alkyl; R1 is hydrogen or R; R2 is hydroxy, C1-6alkoxy, amino, C1-6alkylamino, di(C1-6alkyl)amino; R3 is hydrogen or C1-6alkyl; R4 and R5 are each independently selected from the list consisting of perhaloC1-6alkyl, hydrogen, halo, C1-6alkyl, C1-6alkoxy, hydroxy, amino, C1-6akylamino, di(C1-4alkyl)amino, hydroxyC1-6alkyl, C1-6akoxyC1-6alkyl, aminoC1-6allkyl, (C1-4alkyl)aminoC1-6alkyl, di(C1-4alkyl)aminoC1-4alkyl, aryl, and COX wherein X may be hydroxy, C1-6alkoxy, C1-6alkyl, amino, C1-6alkylamino, or di(C1-6allkyl)amino; with the proviso that, when R3 is hydrogen, then R R4 and R5 are not both hydrogen; and wherein any alkyl group or the alkyl moiety of any group containing such a moiety may be substituted one or more ti
Type:
Application
Filed:
July 30, 2003
Publication date:
February 12, 2004
Inventors:
Daniela Barlocco, Giorgio Cignarella, Giuseppe Giardina, Mario Grugni, Silvano Ronzoni
Patent number: 6613770
Abstract: A compound, or a solvate or a salt thereof, of formula (I):
wherein R is linear or branched alkyl;
R1 represents hydrogen or up to four optional substituents selected from the list consisting of: C1-6 alkyl, C1-6 alkenyl, aryl, C1-6 alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulphonamido, C1-6 alkoxycarbonyl, trifluoromethyl, acyloxy, phthalimido, amino or mono- and di-C1-6 alkylamino;
R2 represents a moiety —(CH2)n—NY1Y2 wherein n is an integer in the range of from 1 to 9, Y1 and Y2 are independently selected from hydrogen; C1-6-alkyl; C1-6 alkyl substituted with hydroxy, C1-6 alkylamino or bis (C1-6 alkyl) amino; C1-6-alkenyl; aryl or aryl-C1-6-alkyl or Y1 and Y2 together with the nitrogen atom to which they are attached represent an optionally substituted N-linked single or fused ring heterocyclic group;
R3 is branched or linear C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkylalkyl, optionally substituted aryl, or an optionally substituted single or fused rin
Type:
Grant
Filed:
September 28, 2001
Date of Patent:
September 2, 2003
Assignees:
SmithKline Beecham S.p.A., SmithKline Beecham Laboratoires Phamaceutiques
Inventors:
Carlo Farina, Giuseppe Giardina, Mario Grugni, Guy Marguerite Marie Gerard Nadler, Luca Francesco Raveglia