Patents by Inventor Giuseppe Gumina

Giuseppe Gumina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metabolically stable puromycin analogs
    Patent number: 7897759
    Abstract: Disclosed are structurally modified, metabolically stable nucleosides having antitumor activity wherein the formation of toxic metabolites is blocked and antimicrobial activity. The disclosure further relates to pharmaceutical compositions comprising one or more disclosed modified nucleosides and to methods of use thereof.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: March 1, 2011
    Assignee: MUSC Foundation for Research Development
    Inventors: Giuseppe Gumina, Roger L. White
  • L-nucleosides as ligands to adenosine receptors
    Patent number: 7423025
    Abstract: Disclosed herein are compounds having Formula I, which are non-natural L-adenosine analogs. Also disclosed are their methods of making. Still further, disclosed are the uses of the disclosed compounds to treat cardiovascular disease, ischemia related injuries; and neurodegenerative diseases. The compounds disclosed herein have the formula: wherein R1 and R2 are, independently, H, branched or straight-chain, substituted or unsubstituted alkyl, alkenyl, alkynyl, or aryl; R3 is branched or straight-chain, substituted or unsubstituted alkyl, hydroxy-alkyl, or —C(?O)NR6R7; and R4 and R5 are, independently, H, hydroxy, halogen, and NR8R9, wherein R6, R7, R8, and R9 are, independently, H, branched or straight-chain, substituted or unsubstituted alkyl, alkenyl, alkynyl, or aryl.
    Type: Grant
    Filed: September 8, 2006
    Date of Patent: September 9, 2008
    Assignee: MUSC Foundation for Research Development
    Inventors: Giuseppe Gumina, Craig C. Beeson, Gary L. Wright
  • L-nucleosides as ligands to adenosine receptors
    Publication number: 20070054875
    Abstract: Disclosed herein are compounds having Formula I, which are non-natural L-adenosine analogs. Also disclosed are their methods of making. Still further, disclosed are the uses of the disclosed compounds to treat cardiovascular disease, ischemia related injuries, and neurodegenerative diseases.
    Type: Application
    Filed: September 8, 2006
    Publication date: March 8, 2007
    Inventors: Giuseppe Gumina, Craig Beeson, Gary Wright
  • ?-2?- or 3?-halonucleosides
    Patent number: 6949522
    Abstract: The present invention includes compounds and compositions of ?-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or compositions.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: September 27, 2005
    Assignees: Pharmasset, Inc., The University of Georgia Research Foundation, Inc., Emory University
    Inventors: Michael J. Otto, Junxing Shi, Chung K. Chu, Raymond F. Schinazi, Giuseppe Gumina, Youhoon Chong, Yongseok Choi
  • BETA-2'-OR 3'-HALONUCLEOSIDES
    Publication number: 20050119286
    Abstract: The present invention includes compounds and compositions of ?-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or compositions.
    Type: Application
    Filed: June 24, 2002
    Publication date: June 2, 2005
    Inventors: Michael Otto, Junxing Shi, Chung Chu, Raymond Schinazi, Giuseppe Gumina, Youhoon Chong, Yongseok Choi