Patents by Inventor Giuseppe Lembo

Giuseppe Lembo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8658598
    Abstract: A recombinant melusin fusion protein having an improved stability and a capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said protein comprises i) a human melusin protein having the amino acid sequence as defined in SEQ ID No.:1, or a homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity to SEQ ID No.:1 and having the function of native melusin protein or a human melusin portion derived from SEQ ID No.:1 or homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity of the melusin portion derived from SEQ ID No.:1 and having the function of native melusin protein and ii) a cell penetrating polypeptide.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: February 25, 2014
    Assignee: Target Heart Biotec S.R.L.
    Inventors: Féderica Accornero, Mara Brancaccio, Guido Tarone, Giuseppe Lembo, Daniela Carnevale
  • Publication number: 20120010386
    Abstract: A recombinant melusin fusion protein having an improved stability and a capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said protein comprises i) a human melusin protein having the amino acid sequence as defined in SEQ ID No.:1, or a homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity to SEQ ID No.:1 and having the function of native melusin protein or a human melusin portion derived from SEQ ID No.:1 or homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity of the melusin portion derived from SEQ ID No.:1 and having the function of native melusin protein and ii) a cell penetrating polypeptide.
    Type: Application
    Filed: May 12, 2011
    Publication date: January 12, 2012
    Applicant: Target Heart Biotec S.r.l.
    Inventors: Federica Accornero, Mara Brancaccio, Guido Tarone, Giuseppe Lembo, Daniela Carnevale
  • Patent number: 7531714
    Abstract: The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be used as models to study heart pathologies and provide therapies thereof, wherein the heart pathologies are heart failure, and in particular diluted cardiomyopathy.
    Type: Grant
    Filed: December 19, 2002
    Date of Patent: May 12, 2009
    Assignee: Universita' Degli Studi de Torino
    Inventors: Mara Brancaccio, Lorenzo Silengo, Fiorella Altruda, Giuseppe Lembo, Luigi Fratta, Guido Tarone
  • Publication number: 20090036382
    Abstract: The present invention relates to molecules preferably of polypeptide nature with negative regulatory activity on the amount or activity of TGF-? through direct interaction with pro-TGF-?, and containing as active region a cysteine-rich polypeptide sequence defined as “EMI domain”, or its subfragments, wherein said “EMI domain” has at least 25% sequence homology to the ID NO2 sequence for pharmaceutical use. Even more preferably said polypeptide sequence consists of the EMI domain of the following proteins: emilin-1, emilin-2 and/or multimerin-2 or their subfragments having a length of at least 6 amino acids, capable of inhibiting the conversion of pro-TGF? to mature TGF? as anti-hypertensive drugs and polypeptides active on the cardiovascular system.
    Type: Application
    Filed: February 1, 2007
    Publication date: February 5, 2009
    Applicants: Universita' Degli Studi Di Padova, Universita' Degli Studi Di Roma "La Sapienza"
    Inventors: Giorgio Bressan, Paolo Bonaldo, Stefano Piccolo, Giuseppe Lembo
  • Publication number: 20060059577
    Abstract: The present invention concerns non-human transgenic animals as model study for human pathologies, being transgenic for having altered melusin expression. The non-human transgenic animals are to be used as models to study heart pathologies and provide therapies thereof, wherein the heart pathologies are heart failure, and in particular diluted cardiomyopathy.
    Type: Application
    Filed: December 19, 2002
    Publication date: March 16, 2006
    Inventors: Mara Brancaccio, Lorenzo Silengo, Fiorella Altruda, Giuseppe Lembo, Luigi Fratta, Guido Tarone