Abstract: A bone staple system configured to secure one or more bone segments and related methods is provided.

Abstract: A system and method for loading a suture construct on a soft tissue graft with a graft assembly. The graft assembly includes a suture construct having a closed end and an open end; a first tail of suture and a second tail of suture positioned adjacent to the open end; a first closed loop positioned at the closed end formed from the first and second tails of suture; a first splice formed by the first tail in the second tail between the closed loop and the open end; a second closed loop formed from the first and second tails of suture between the splice and the open end; and a second splice formed by the first tail in the second tail between the second closed loop and the open end.

Abstract: An anchor construct having an anchor having a length of suture material passing therethrough, the suture material having a loop strand terminating at a first end and a post strand terminating at a second end, a splice loop formed by first end, a sliding construct formed by the first end and the second end, wherein the sliding construct is configured to adjust the relative position of the splice loop and the anchor. The anchor construct can be deployed by passing the first end through a first body and through the splice, creating a locking loop of a first size around the first body, implanting the anchor into a bone hole, pulling the post strand to decrease the perimeter of the positioning loop to a second size smaller than the first size, and pulling the loop strand to decrease the perimeter of the locking loop to a smaller second size.

Abstract: An anchor is provided for placement in or against tissue. The anchor includes a flat fibrous construct having a first end and a second end; and a filament having a first end and a second end passing through the fibrous construct in two locations including a first passing location nearest a first end of the fibrous construct, a second passing location nearest a second end of the fibrous construct, the filament remaining free to slide through the first passing location and the second passing location such that the filament can be removed from the flat fibrous construct from the first end of the fibrous construct and the second end of the fibrous construct. The anchor can be inserted into a bone hole and deployed.

Abstract: A pharmaceutical composition for an ophthalmic use either in humans or mammalians for a treatment of eye disorders is provided. The pharmaceutical composition includes an effective amount of an oxidizing agent and an effective amount of a photo-sensitizing agent, in combination with pharmaceutically acceptable excipients; the photo-sensitizing agent is a molecule having an absorbance peak in a wavelength range between 340 nm and 440 nm and emits fluorescence in a wavelength range between 450 nm and 600 nm; the oxidizing agent is chosen among molecules, wherein the molecules partially or totally inhibit a mitochondrial electron transport chain activity, wherein the pharmaceutical composition is a liquid formulation further includes one or more substances chosen among: diluents, permeabilizers, disinfectants, buffer systems, salts, antiseptics, and the pharmaceutically acceptable excipients.

Abstract: A system and method for loading a suture construct on a soft tissue graft with a graft assembly. The graft assembly includes a frame with an opening extending between a proximal end and a distal end. The frame has a wall with a first side extending to a first edge and a second side extending to a second edge. A lumen extends between the first side and the second side and a plurality of channels extend through the wall between the first edge and the second edge. The graft assembly also includes a transverse hole extending through the proximal end of the frame and a pin removably inserted into the transverse hole.

Abstract: A knotless suture anchor assembly for engaging a bone tunnel and holding suture therein to knotlessly secure said suture to soft tissue including an elongated generally cylindrical hollow outer member having an axial lumen, an outer surface with projections for engaging the wall of the bone tunnel, a distal end and a proximal end; and an elongated, generally cylindrical inner member having an axis, a proximal end and a distal end, the distal end having a transverse passage for receiving suture therethrough, the transverse passage having a proximal and distal end and adapted to receive a plurality of sutures in said eyelet, the inner member adapted to move coaxially relative to the outer member between a distal, suture-unlocked position and a proximal, suture-locked position.

Abstract: A knotless instability anchor having an anchor having a first side and a second side with a suture material passing therethrough from the first side to the second side. The suture material has an adjustable loop extending from the first side of the anchor and a first limb and a second limb extending from the second side of the anchor. A splice is formed in the first limb between a first end of the first limb and the anchor. A self-collapsing loop is formed in the first limb between the first end and the splice. The second limb extends through the splice in the first limb.

Abstract: Control apparatus (1) for controlling the dosing of a chromophoric agent (100) in a corneal tissue (101), comprising: a first source (2) for irradiating the corneal tissue (101) with at least a first electromagnetic radiation (21); first measurement means (3) for measuring a first spectroscopic parameter (31), such as the fluorescence intensity or the diffused intensity; a processing unit (4) configured to calculate a factor (C) representative of the concentration of the chromophoric agent (100) inside the corneal tissue (101) in response to at least two measurements of the first spectroscopic parameter (31), of which one measurement is indicative of the energy perturbation caused by the first electromagnetic radiation (21) in the corneal tissue (101) without the chromophoric agent (100) and the further measurement is indicative of the energy perturbation caused by the first electromagnetic radiation (21) in the corneal tissue (101) containing the chromophoric agent (100).

Abstract: An anchor is provided for placement in or against tissue. The anchor includes a flat fibrous construct having a first end and a second end; and a filament having a first end and a second end passing through the fibrous construct in two locations including a first passing location nearest a first end of the fibrous construct, a second passing location nearest a second end of the fibrous construct, the filament remaining free to slide through the first passing location and the second passing location such that the filament can be removed from the flat fibrous construct from the first end of the fibrous construct and the second end of the fibrous construct. The anchor can be inserted into a bone hole and deployed.

Abstract: An anchor construct having an anchor having a length of suture material passing therethrough, the suture material having a loop strand terminating at a first end and a post strand terminating at a second end, a splice loop formed by first end, a sliding construct formed by the first end and the second end, wherein the sliding construct is configured to adjust the relative position of the splice loop and the anchor. The anchor construct can be deployed by passing the first end through a first body and through the splice, creating a locking loop of a first size around the first body, implanting the anchor into a bone hole, pulling the post strand to decrease the perimeter of the positioning loop to a second size smaller than the first size, and pulling the loop strand to decrease the perimeter of the locking loop to a smaller second size.

Abstract: An articulating suture hook for passing or retrieving suture. The suture hook having a handle with a proximal end and distal end. A stiffening tube is fixed to the distal end of the handle extending distally from the handle. A flexible outer tube is fixed to the stiffening tube and extends distally therefrom. A cut portion of the flexible outer tube has a plurality of cuts positioned therealong. In a first configuration, the flexible outer tube extends parallel to or in alignment with the stiffening tube, but in a second configuration, the flexible outer tube is curved at the cut portion. The plurality of cuts may be arranged into two patterns. Each cut arranged in a first pattern is offset at an angle from each cut arranged in a second pattern. The pattern, shape, and size of the cuts determines the movement of the flexible outer tube to the second configuration.

Abstract: A knotless instability anchor having an anchor having a first side and a second side with a suture material passing therethrough from the first side to the second side. The suture material has an adjustable loop extending from the first side of the anchor and a first limb and a second limb extending from the second side of the anchor. A splice is formed in the first limb between a first end of the first limb and the anchor. A self-collapsing loop is formed in the first limb between the first end and the splice. The second limb extends through the splice in the first limb.

Abstract: A deployment device, including a driver shaft; an implant attached to the distal end of the driver shaft; a handle assembly connected to the proximal end of the driver shaft including a handle and a knob positioned distally to the handle; a cleat configured to secure a proximal end of a suture received from the implant through an aperture of the driver shaft resulting in a first applied tension value when the implant is placed in a pilot hole, wherein each of the implant, proximal handle and cleat is connected to the driver shaft such that rotation of the proximal handle in a first direction results in the rotation of the implant in the first direction and the maintenance of at least 50% of the first applied tension value when the implant is rotated in the first direction and advanced in the distal direction within the pilot hole.

Abstract: A device for delivering a drug into a cornea is provided. The device includes a body having an internal cavity and a first aperture communicating with the internal cavity, wherein the first aperture is conformed to hermetically adhere to a periphery of a surface of the cornea; a second aperture to introduce the drug in the internal cavity, the device further includes a mask, supported by the body in correspondence of the first aperture, wherein, in operative condition, the first aperture adheres to a portion of the surface of the cornea, and the mask includes a plurality of through openings of opportunely variable size to achieve a corresponding variable spatial concentration of the drug across the cornea.

Abstract: A suspensory fixation device has an elongated anchor member adapted to be transversely situated at the exit of a bone tunnel. A graft supporting loop member formed of a pair of parallel suture limbs extending from a bight portion is suspended transversely from the anchor member and has a loop length which is adjustable so the graft ligament can be supported in the bone tunnel at varying distances from the anchor member. When a graft ligament is attached to the saddle end of the loop member, the length may be shortened by pulling distally on the pair of limbs to pull the graft ligament into the bone tunnel. When tension is applied to the loop member by the graft pulling the loop proximally, the bight portion of the suture automatically locks the graft supporting loop member in place.

Abstract: A system and method for repairing soft tissue tears such as meniscal tears. The anchor system has a first implant connected to a length of suture. The length of suture is folded such that a tensioning limb extends from the first implant and a locking limb extends from the first implant. The anchor system also includes a second implant fixed to the locking limb and an adjustment mechanism in the length of suture between the first implant and the second implant. The tensioning limb is passed through the adjustment mechanism. This creates an adjustment loop in the length of suture extending from the adjustment mechanism through the first implant. The adjustment loop is a one-way adjustable loop for moving the first implant and second implant in relative position to each other.

Abstract: A system and method for loading a suture construct on a soft tissue graft with a graft assembly. The graft assembly includes a frame with an opening extending between a proximal end and a distal end. The frame has a wall with a first side extending to a first edge and a second side extending to a second edge. A lumen extends between the first side and the second side and a plurality of channels extend through the wall between the first edge and the second edge. The graft assembly also includes a transverse hole extending through the proximal end of the frame and a pin removably inserted into the transverse hole.

Abstract: A system and method of repairing an ACL using a fixation device and a pre-sutured tendon. The fixation device includes a button having first and second inner apertures extending therethrough and a length of suture having a first limb connected to a second limb. The first and second limbs both extend through the first inner aperture, forming an adjustable loop in the length of suture extending from the button. A mass of suture material or a protuberance is formed in a first terminal end of the first limb extending proximally from the button. The mass of suture material and the protuberance have a diameter that is larger than a diameter of the first inner aperture. Pulling the second limb proximally from the button decreases the size of the adjustable loop.