Patents by Inventor Giuseppe Lucchese

Giuseppe Lucchese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expression and secretion of mature human beta interleukin-1 in Bacillus subtilis and means and methods for its achievement
    Patent number: 5728571
    Abstract: A new plasmid vector is described which can replicate in B. subtilis and which can express and secrete, in the culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences extraneous to the natural molecule, a strain of B. subtilis transformed by the vector and a method for the expression and secretion of mature human beta interleukin-1. The human beta interleukin-1 thus obtained shows a specific acitvity of 1.times.10.sup.9 U/mg of protein and is particularly suitable as a stimulant for the immune system, as an adjuvant in vaccines for the activation of the repair mechanism in cases of tissue damage, and for the treatment of auto-immune diseases in man.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: March 17, 1998
    Assignee: Eniricerche S.p.A.
    Inventors: Ada Velati Bellini, Giuliano Galli, Giuseppe Lucchese, Guido Grandi
  • Inertization of liquid waste, mud and solid waste containing heavy metals by sulphate-reducing bacteria
    Patent number: 5660730
    Abstract: Process for the inertization of liquid waste, mud and solid waste, containing sulphates and heavy metals, which comprises a neutralization step of the compounds to be treated and an anaerobic reduction step of the sulphate ion to allow the formation of sulphide ions necessary for the process. A consortium of sulphate-reducing bacteria and lactobacilli is used, with whey as a carbon and nitrogen source.
    Type: Grant
    Filed: July 7, 1995
    Date of Patent: August 26, 1997
    Assignee: Eniricerche S.p.A.
    Inventors: Giuseppe Lucchese, Andrea Robertiello, Giuseppe Scolla
  • Cloning of the gene coding the isoamylase enzyme and its use in the production of said enzyme
    Patent number: 5457037
    Abstract: The structural gene encoding isoamylase from Pseudomonas SMP 1 is obtained. Also described are vectors comprising the isoamylase gene and host microorganisms transformed by these vectors. The transformed host microorganisms are capable of expressing and/or secreting mature isoamylase having biological activity.
    Type: Grant
    Filed: January 8, 1993
    Date of Patent: October 10, 1995
    Assignee: Enichem Synthesis, S.p.A.
    Inventors: Angelo Tognoni, Paolo Carrera, Barbara Camerini, Giuliano Galli, Giuseppe Lucchese, Guido Grandi, Carlo Di Gennaro
  • Expression and secretion of mature human beta interleukin-1 in Bacillus subtilis and means and methods for its achievement
    Patent number: 5437988
    Abstract: A new plasmid vector is described which can replicate in B.subtilis and which can express and secrete, in the culture medium, human beta interleukin-1 (beta IL-1) without amino acid sequences extraneous to the natural molecule, a strain of B.subtilis transformed by the vector and a method for the expression and secretion of mature human beta interleukin-1. The human beta interleukin-1 thus obtained shows a specific acitvity of 1.times.10.sup.9 U/mg of protein and is particularly suitable as a stimulant for the immune system, as an adjuvant in vaccines for the activation of the repair mechanism in cases of tissue damage, and for the treatment of auto-immune diseases in man.
    Type: Grant
    Filed: June 7, 1993
    Date of Patent: August 1, 1995
    Assignee: Eniricerche S.p.A.
    Inventors: Ada V. Bellini, Giuliano Galli, Giuseppe Lucchese, Guido Grandi