Patents by Inventor Giuseppe Manfredi

Giuseppe Manfredi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]acenaphthylene and functionalized derivatives
    Patent number: 6897311
    Abstract: A process for the preparation of compound of formula (I A), decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]accnaphthylene and the corresponding functionalized compounds of general formula (I), intermediates for the preparation of 1,4,7,10-tetraazacyclododecane (II A) and corresponding derivatives (II), by preparation of compounds of general formula (III) and subsequent reduction thereof.
    Type: Grant
    Filed: April 10, 2001
    Date of Patent: May 24, 2005
    Assignee: Bracco International BV
    Inventors: Maria Argese, Marino Brocchetta, Giuseppe Manfredi, Fabrizio Rebasti, Giorgio Ripa
  • Process for the preparation of 3-glutamido bile ester derivatives using n-prtotected methyl proglutamate
    Publication number: 20040138185
    Abstract: The present invention relates to a novel process for the preparation of bile esters derivatives of general formula (1), in which R0 is H or OH; R1 is H, &agr;-OH or &bgr;-OH; R2 and R3 are independently hydrogen, straight or branched (C1-C20) alkyl optionally substituted with aryl; R5 is a straight or branched (C1-C4) alkyl and R6 is a straight or branched (C1-C4) alkyl or a benzyl group, via transamidation of the amine (V) with the 5-ocoproline derivative (II), wherein R4 is selected from the group consisting of tertbutoxycarbonyl, methoxycarbonyl, ethoxycarbonyl, 2-trimethylsilylethoxycarbonyl, cyclobutoxycarbonyl and 1-methylcyclobutoxy carbonyl, followed by the selective cleavage of the protecting group R4 under acidic conditions.
    Type: Application
    Filed: March 12, 2004
    Publication date: July 15, 2004
    Inventors: Marino Brocchetta, Pier Lucio Anelli, Giuseppe Manfredi, Massimo Visigalli, Daniela Palano, Laura Alessandroni
  • Process for the preparation of decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]acenaphthylene and functionalized derivatives
    Publication number: 20040014974
    Abstract: A process for the preparation of compound of formula (I A), decahydro-2a,4a,6a,8a-tetraazacyclopent[fg]accnaphthylene and the corresponding functionalized compounds of general formula (1), intermediates for the preparation of 1,4,7,10-tetraazacyclododecane (II A) and corresponding derivatives (II), by preparation of compounds of general formula (III) and subsequent reduction thereof.
    Type: Application
    Filed: November 25, 2002
    Publication date: January 22, 2004
    Inventors: Maria Argese, Marino Brocchetta, Giuseppe Manfredi, Fabrizio Rebasti, Giorgio Ripa
  • Process for the preparation of 1,4,7,10-tetraazacyclododecane
    Patent number: 6653470
    Abstract: 1,4,7,10-Tetraazacyclodecane, a precursor for the synthesis of macrocylic chelating agents for metal ions such as gadolinium, is prepared efficiently as a highly pure product on an industrial scale.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: November 25, 2003
    Assignee: Bracco International B.V.
    Inventors: Maria Argese, Giuseppe Manfredi, Fabrizio Rebasti, Giorgio Ripa
  • Use of bile acid conjugates, derivatives thereof with metal complexes as blood pool agents for nuclear magnetic resonance diagnostics
    Patent number: 6461588
    Abstract: Blood pool imaging contrast agents containing paramagnetic bi- and tri-valent metal ion chelates of bile acid conjugates with molecules having chelating activity are used in magnetic resonance imaging of the vascular system and particularly the coronaries.
    Type: Grant
    Filed: May 26, 1999
    Date of Patent: October 8, 2002
    Assignee: Bracco Imaging S.p.A.
    Inventors: Pier Lucio Anelli, Marino Brocchetta, Christoph De Haen, Ornella Gazzotti, Luciano Lattuada, Giovanna Lux, Giuseppe Manfredi, Pierfrancesco Morosini, Daniela Palano, Michele Serleti, Fulvio Uggeri, Massimo Visigalli
  • Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
    Patent number: 5708166
    Abstract: This invention relates to novel compounds able to chelate paramagnetic bi- or trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI).
    Type: Grant
    Filed: January 14, 1997
    Date of Patent: January 13, 1998
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Pier Lucio Anelli, Giuseppe Manfredi, Marino Brocchetta, Franco Fedeli
  • Macrocyclic chelants, their chelates and uses thereof in the diagnostic field
    Patent number: 5622688
    Abstract: This invention relates to novel compounds able to chelate paramagnetic bi- or trivalent metal ions, their chelates with said metal ions and their use as contrast agents in magnetic resonance imaging (MRI).
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: April 22, 1997
    Assignee: Dibra S.p.A.
    Inventors: Fulvio Uggeri, Pier L. Anelli, Giuseppe Manfredi, Marino Brocchetta, Franco Fedeli