Abstract: A process for three-dimensional shaping of a biological and/or artificial tissue/tissue component. The process is consistent for shaping tissues and can produce a desired three-dimensional and permanent shaping of the tissue/tissue component via crosslinking. A suitable crosslinking agent is used in combination with shaped body and a granulate.

Abstract: A medical implant, such as a transcatheter deliverable endoprosthesis or a prosthetic heart valve including a stent-structure, one or more skirts and optionally a valve assembly. One or more skirts and/or the one or more leaflets include one or more laser markings that partially or fully penetrate a thickness of the one or more skirts and/or the one or more leaflets. The laser marks are preferably sufficiently big to be optically visible at the surface of the outer skirt by an operator during a sewing process. Each laser marking may be used for suturing, wherein the reduced material thickness eases the suturing/sewing process without compromising the structural integrity of the material of the outer skirt (e.g.

Abstract: The present invention concerns a prosthetic valve device for treatment of mitral valve insufficiency, as well as methods of manufacturing the device. The device comprises a main body with a flexible stent frame and a prosthetic material covering the stent frame at least partially, and a valve structure, wherein the valve structure is formed by wire-elements having elongated loop-structures with prosthesis material attached thereto.

Abstract: The invention relates to an apparatus (100) for determining properties of a sample (110) arranged in at least one receptacle (130) of a container device (120). The apparatus (100) comprises an actuator (30) which is configured to be coupled to the sample (110) via at least one holding element (34) which is configured to hold the sample (110). Further, the actuator (30) is configured to apply a mechanical stimulus to the sample (110) via the at least one holding element (34). The apparatus (100) comprises a force sensing device (20) which is configured to be coupled to the sample (110) via at least one cantilever (22). Further, the apparatus (100) comprises a frame (1), wherein the actuator (30) and the force sensing device (20) are configured to be mounted to the frame (1), and wherein the frame (1) is configured to be arranged on the container device (120).

Abstract: A vascular implant, in particular a prosthetic heart valve, for providing valve function, has a stent structure with a proximal conical-convex inflow region, a distal, linear cylindrical outflow region, an intermediate transition region, and a corresponding valve arrangement. When the stent structure is in the expanded state, a higher maximum radial force exists in the inlet region in direct comparison to the lower maximum radial force in the outlet region and in the transition region.