Abstract: The present disclosure concerns a group of cannabinoid compounds defined by formulas (I) to (IV), wherein R1 is —H or —COOH, for the first time isolated and fully characterized in structure, absolute stereochemistry by the present applicant. Methods of isolation, characterization, stereoselective synthesis, biological activity, pharmaceutical composition and therapeutic applications of the present compounds as modulators of the cannabinoid CB1 receptor are also object of the disclosure.

Abstract: A coupling system for peripheral devices may include a housing and a shaft assembly. An end of the shaft assembly is threaded and couples to and uncouples from a peripheral device by relative rotational movement between the peripheral device and the shaft assembly. An inner cavity of the housing and another end of the shaft assembly defines a limited range of rotational motion between first and second rotational positions. Rotating the shaft assembly to the first rotational position allows for the peripheral device to be rotated relative to both the shaft assembly and the housing to couple the peripheral device to the housing via the shaft assembly. With the peripheral device coupled to the shaft assembly, relative rotational motion between the peripheral device and the housing is allowed between the first rotational position and the second rotational position without rotating the peripheral device relative to the shaft assembly.

Abstract: A pad for disc brakes for railway vehicles comprising a base plate (2), a plurality of friction elements fixed to the base plate and a plurality of spacers, each of which is mounted between the base plate and a respective friction element. In each one of the spacers at least one fixing hole is obtained, which is engaged by a respective rivet suited to lock the friction element to the base plate. Each one of the spacers consists of a plurality of metal plaques, each having a fixing hole obtained in it. The metal plaques are stacked on top of one another so that the respective fixing holes coincide.

Abstract: A mount includes a first linkage having a front face that extends in a first direction and faces in a second direction that is perpendicular to the first direction, a second linkage slidably connected to the first linkage, the second linkage comprising a body portion extending in the first direction and a neck portion disposed at an end of the body portion of the second linkage, a third linkage rotatably connected to the first linkage at a first end of the third linkage, a telescoping element slidably connected to the third linkage, the telescoping element comprising an abutment portion at an end of the telescoping element, and a housing attachment mechanism coupled to a first surface of the neck portion of the second linkage.

Abstract: The present disclosure relates to highly reflective coating formulations that produce coatings having an average infrared reflectivity ranging from about 75% to about 90% at wavelengths ranging from about 0.5 ?m to about 1000 ?m, methods for making the coatings and coating mixtures, and substrates comprising such coatings.