Patents by Inventor Giuseppe Saglio

Giuseppe Saglio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLO DERIVATIVES AS HUMAN DIHYDROOROTATE DEHYDROGENASE (HDHODH) INHIBITORS FOR USE AS ANTIVIRALS
    Publication number: 20240034730
    Abstract: The invention relates to hDHODH inhibitors, in particular 2-hydroxypyrazolo[1,5-a]pyridine derivatives, for use as antiviral agents. The hDHODH inhibitors for use according to the invention are effective as inhibitors of the replication of a wide spectrum of both DNA and RNA viruses, including, i.a., Herpes simplex virus 1 (HSV-1), Herpes simplex virus 2 (HSV-2), Influenza A virus, Influenza B virus, Respiratory syncytial virus (RSV), Severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome-related coronavirus (MERS-CoV).
    Type: Application
    Filed: November 12, 2021
    Publication date: February 1, 2024
    Inventors: Donatella Boschi, Marta Giorgis, Marco Lucio Lolli, Giovanni Martinelli, Giuseppe Saglio
  • NOVEL HUMAN DIHYDROOROTATE DEHYDROGENASE (hDHODH) INHIBITORS AND THEIR USE IN TARGETING ONCOLOGICAL DISEASES SENSITIVE TO PYRIMIDINE STARVATION
    Publication number: 20210230156
    Abstract: Compounds of formulae (I) and (II) which are novel inhibitors of human dihydroorotate dehydrogenase (hDHODH) and pharmaceutical compositions containing the compounds of formulae (I) and (II) are provided. A method for treating tumor diseases, including acute myelogenous leukemia (AML), triple-negative breast cancer, PTEN-mutant tumors, and KRAS-driven tumors by administering pharmaceutical compositions containing the compounds of formulae (I) and (II) is also provided.
    Type: Application
    Filed: June 6, 2019
    Publication date: July 29, 2021
    Inventors: Donatella BOSCHI, Marta GIORGIS, Marco Lucio LOLLI, Giovanni MARTINELLI, Giuseppe SAGLIO
  • Immunogenic Peptides, Nucleic Acids Encoding The Same And Use Thereof In Cancer Treatment And Diagnosis
    Publication number: 20080107662
    Abstract: The invention discloses alternative splice variants in Philadelphia chromosome positive leukemia, immunogenic peptides and proteins thereby produced and the use thereof in the preparation of antitumor agents.
    Type: Application
    Filed: July 15, 2005
    Publication date: May 8, 2008
    Inventors: Vito Michele Fazio, Gisella Volpe, Giuseppe Saglio
  • DNA vaccines expressing hypervariable VH-CDR3 idiotypic determinants
    Patent number: 7354759
    Abstract: The present invention relates to a method for inducing the immune response of an individual against B-lymphoproliferative disorders. The method is based on DNA vaccination with the short peptide encompassing the CDR3 hypervariable region of immunoglobulin heavy chain (VH-CDR3) alone or in combination with at least another immunomodulating sequence.
    Type: Grant
    Filed: January 15, 2001
    Date of Patent: April 8, 2008
    Assignee: Keryos SpA
    Inventors: Vito M. Fazio, Giuseppe Saglio
  • Dna vaccines expressing hypervariable vh-cdr3 idiotipic determinants
    Publication number: 20040109849
    Abstract: The present invention relates to a method for inducing the immune response of an individual against B-lymphoproliferative disorders. The method is based on DNA vaccination with the short peptide encompassing the CDR3 hypervariable region of immunoglobulin heavy chain (VH-CDR3) alone or in combination with at least another immunomodulating sequence.
    Type: Application
    Filed: December 8, 2003
    Publication date: June 10, 2004
    Inventors: Vito M Fazio, Giuseppe Saglio