Publication number: 20130210753
Abstract: The invention relates to methods of treating Duchenne muscular dystrophy with flavonoids. The methods may include (a) providing a pharmaceutical composition comprising a therapeutically effective amount of flavonoid, and (b) administering the composition to a human patient, wherein the flavonoid comprises an isoflav-4-one with at least one of the carbons located at positions 8, 7, 6, 5, 2, 2?, 3?, 4?, 5?, or 6? modified by an alcohol group. Alternatively, the flavonoid may comprise (1) a flavan-3-ol with at least one of the carbons located at positions 8, 7, 6, 5, 4, 2?, 3?, 4?, 5?, or 6? modified by an alcohol group, or (2) a Free-B-Ring flavone with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by an alcohol group and with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by a glycoside group.
Type:
Application
Filed:
June 1, 2012
Publication date:
August 15, 2013
Applicant:
PRIMUS PHARMACEUTICALS INC.
Inventors:
Francesco Squadrito, Alessandra Bitto, Giuseppe Vita, Sonia Messina, Bruce P. Burnett
Publication number: 20100190733
Abstract: The invention relates to methods of treating Duchenne muscular dystrophy with flavonoids. The methods may include (a) providing a pharmaceutical composition comprising a therapeutically effective amount of flavonoid, and (b) administering the composition to a human patient, wherein the flavonoid comprises an isoflav-4-one with at least one of the carbons located at positions 8, 7, 6, 5, 2, 2?, 3?, 4?, 5?, or 6? modified by an alcohol group. Alternatively, the flavonoid may comprise (1) a flavan-3-ol with at least one of the carbons located at positions 8, 7, 6, 5, 4, 2?, 3?, 4?, 5?, or 6? modified by an alcohol group, or (2) a Free-B-Ring flavone with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by an alcohol group and with at least one of the carbons located at positions 8, 7, 6, 5 or 3 modified by a glycoside group.
Type:
Application
Filed:
January 26, 2010
Publication date:
July 29, 2010
Applicant:
Primus Pharmaceuticals, Inc.
Inventors:
Francesco Squadrito, Alessandra Bitto, Giuseppe Vita, Sonia Messina, Bruce P. Burnett