Patents by Inventor Giuseppina Maria INCISIVO

Giuseppina Maria INCISIVO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of GLP-1 analogues
    Patent number: 11396533
    Abstract: The present invention provides a process for the manufacture of GLP-1 analogues with high yield and purity by fragment condensation on the solid phase. In particular, it describes a convergent synthesis by condensation of a C-terminal pseudoproline fragment A with a fragment B bound to a solid support, followed by deprotection and cleavage from the support and final purification to yield the desired peptide. The invention further provides intermediates useful in the manufacturing process.
    Type: Grant
    Filed: October 9, 2019
    Date of Patent: July 26, 2022
    Assignee: FRESENIUS KABI IPSUM S.R.L.
    Inventors: Giuseppina Maria Incisivo, Andrea Orlandin, Antonio Ricci, Ivan Guryanov, Walter Cabri
  • PROCESS FOR THE MANUFACTURE OF GLP-1 ANALOGUES
    Publication number: 20220041680
    Abstract: The present invention provides a process for the manufacture of GLP-1 analogues with high yield and purity by fragment condensation on the solid phase. In particular, it describes a convergent synthesis by condensation of a C-terminal pseudoproline fragment A with a fragment B bound to a solid support, followed by deprotection and cleavage from the support and final purification to yield the desired peptide. The invention further provides intermediates useful in the manufacturing process.
    Type: Application
    Filed: October 9, 2019
    Publication date: February 10, 2022
    Applicant: FRESENIUS KABI IPSUM S.R.L.
    Inventors: Giuseppina Maria INCISIVO, Andrea ORLANDIN, Antonio RICCI, Ivan GURYANOV, Walter CABRI