Abstract: The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.

Abstract: The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.

Abstract: The invention relates to new 2,3-benzodiazepine derivatives of formula (I), isomers and acid addition salts thereof and to pharmaceutical compositions containing the same, as well as to pharmaceutical compositions and methods of using the same suitable for treating conditions associated with muscle spasms, epilepsy, acute and chronic forms of neurodegenerative diseases as well as preventing, treating or alleviating the symptoms of acute and chronic inflammatory disorders.

Abstract: Compounds of formula I are described, their production and use in pharmaceutical agents.

Abstract: 2,3-Benzodiazepines of formula (I), their stereoisomers and acid addition salts, wherein the variables have the meaning given in the specification, and pharmaceutical compositions containing them which are suitable for treating conditions associated with muscle spasms, epilepsy as well as acute and chronic forms of neurodegenerative diseases are disclosed.

Abstract: Compounds of formula I are described, their production and use in pharmaceutical agents.

Abstract: The invention concerns compounds of formula (I), in which R1, R2, R3 and R4 mean hydrogen or different substituents; X means hydrogen or halogen; Y means C1-6 alkoxy or X and Y together mean —O—(CH2)n—O—; n means 1, 2 or 3; and A together with nitrogen forms a saturated or unsaturated five-member heterocycle which can contain between 1 and 3 nitrogen atoms and/or an oxygen atom and/or one or two carbonyl groups. Owing to their non-competitive inhibiting of the AMPA receptors, these compounds can be used as medicaments for treating diseases of the central nervous system.

Abstract: A compound of formula I in which X means hydrogen or halogen, Y means —NR3— or —N═, R1 and R2 are the same or different and mean hydrogen, C1-C6 alkyl, nitro, halogen, the group —NR8R9, —O—C1-4 alkyl, —CF3, OH or C1-6 alkanoyloxy, R3 means hydrogen, the group —CO—R10, C1-6 alkyl or C3-7 cycloalkyl, R4 means optionally substituted C1-C6 alkyl, R5 means hydrogen or R4 and R5 together mean oxygen, R6 means C1-4 alkyl, R8 and R9 are the same or different and mean hydrogen, C1-C6 alkyl or —CO—C1-6 alkyl, R10 means hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C6-10 aryl, the group —NR11R12, —O—C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or —O—C3-7 cycloalkyl, R11 and R12 are the same or different and mean hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C6-10 aryl and —C...C...

Abstract: Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions.

Abstract: A novel 1,1,2-triphenylpropene derivative, namely: ##STR1## acts on the endocrine system of rats. It exerts oestrogenic or antioestrogenic effects of varying strength in rats, and furthermore inhibits the growth of the mammary tumor induced by 7,12-dimethyl-benz(a)anthracene in rats.