Patents by Inventor Glauco R. Souza

Glauco R. Souza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10844365
    Abstract: Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: November 24, 2020
    Assignees: William Marsh Rice University, The Board of Regents of the University of Texas System
    Inventors: Glauco R. Souza, Renata Pasqualini, Wadih Arap, Thomas Charles Killian, Robert M. Raphael, Daniel Joshua Stark
  • Publication number: 20190242881
    Abstract: Cells are grown in 3D culture and topological features obtained by photomicrography are correlated to cell viability and cell interactions.
    Type: Application
    Filed: April 9, 2019
    Publication date: August 8, 2019
    Inventor: Glauco R. Souza
  • Patent number: 10288603
    Abstract: Cells are grown in 3D culture and topological features obtained by photomicrography are correlated to cell viability and cell cell interactions.
    Type: Grant
    Filed: January 13, 2012
    Date of Patent: May 14, 2019
    Assignee: Greiner Bio-One North America, Inc.
    Inventor: Glauco R. Souza
  • Patent number: 10265396
    Abstract: Methods of making and using a magnetic ECM are disclosed. The ECM comprises positively and negatively charged nanoparticles, wherein one of said nanoparticles contains a magnetically responsive element. When the magnetic ECM is seeded with cells, the cells will be magnetized and can be levitated for 3-D cell culture.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: April 23, 2019
    Assignee: Greiner Bio-One North America, Inc.
    Inventor: Glauco R. Souza
  • Publication number: 20180265858
    Abstract: Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.
    Type: Application
    Filed: March 5, 2018
    Publication date: September 20, 2018
    Inventors: Glauco R. SOUZA, Renata Pasqualini, Wadih ARAP, Thomas Charles KILLIAN, Robert M. RAPHAEL, Daniel Joshua STARK
  • Patent number: 9909116
    Abstract: Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.
    Type: Grant
    Filed: July 15, 2014
    Date of Patent: March 6, 2018
    Assignee: WILLIAM MARSH RICE UNIVERSITY
    Inventors: Glauco R Souza, Renata Pasqualini, Wadih Arap, Thomas Charles Killian, Robert M. Raphael, Daniel Joshua Stark
  • Publication number: 20180000936
    Abstract: Methods of making and using a magnetic ECM are disclosed. The ECM comprises positively and negatively charged nanoparticles, wherein one of said nanoparticles contains a magnetically responsive element. When the magnetic ECM is seeded with cells, the cells will be magnetized and can be levitated for 3-D cell culture.
    Type: Application
    Filed: September 18, 2017
    Publication date: January 4, 2018
    Inventor: Glauco R. SOUZA
  • Patent number: 9764030
    Abstract: Methods of making and using a magnetic ECM are disclosed. The ECM comprises positively and negatively charged nanoparticles, wherein one of said nanoparticles contains a magnetically responsive element. When the magnetic ECM is seeded with cells, the cells will be magnetized and can be levitated for 3-D cell culture.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: September 19, 2017
    Assignee: Nano3D Biosciences Inc
    Inventor: Glauco R. Souza
  • Patent number: 9731391
    Abstract: Camera phone accessories for using the camera phone to collect scientific data.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: August 15, 2017
    Assignee: Nano3D Biosciences Inc.
    Inventors: Glauco R. Souza, Jianbo Chen
  • Patent number: 9688955
    Abstract: A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: June 27, 2017
    Assignee: Nano3D Biosciences, Inc.
    Inventor: Glauco R. Souza
  • Publication number: 20150110752
    Abstract: Methods of making and using a magnetic ECM are disclosed. The ECM comprises positively and negatively charged nanoparticles, wherein one of said nanoparticles contains a magnetically responsive element. When the magnetic ECM is seeded with cells, the cells will be magnetized and can be levitated for 3-D cell culture.
    Type: Application
    Filed: June 11, 2013
    Publication date: April 23, 2015
    Inventor: Glauco R. Souza
  • Publication number: 20150104844
    Abstract: A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.
    Type: Application
    Filed: November 7, 2014
    Publication date: April 16, 2015
    Inventor: Glauco R. SOUZA
  • Publication number: 20150091233
    Abstract: Camera phone accessories for using the camera phone to collect scientific data.
    Type: Application
    Filed: April 22, 2013
    Publication date: April 2, 2015
    Inventors: Glauco R. Souza, Jianbo Chen
  • Patent number: 8883471
    Abstract: A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: November 11, 2014
    Assignee: N3D Biosciences, Inc.
    Inventor: Glauco R. Souza
  • Publication number: 20140322784
    Abstract: Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.
    Type: Application
    Filed: July 15, 2014
    Publication date: October 30, 2014
    Inventors: Glauco R. SOUZA, Renata Pasqualini, Wadih ARAP, Thomas Charles KILLIAN, Robert M. RAPHAEL, Daniel Joshua STARK
  • Patent number: 8815231
    Abstract: Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.
    Type: Grant
    Filed: March 24, 2011
    Date of Patent: August 26, 2014
    Assignees: William Marsh Rice University, Board of Regents, The University of Texas System
    Inventors: Glauco R. Souza, Renata Pasqualini, Wadih Arap, Thomas Charles Killian, Robert M. Raphael, Daniel Joshua Stark
  • Publication number: 20130280754
    Abstract: Cells are grown in 3D culture and topological features obtained by photomicrography are correlated to cell viability and cell cell interactions.
    Type: Application
    Filed: January 13, 2012
    Publication date: October 24, 2013
    Applicant: Nano3D Biosciences, Inc.
    Inventor: Glauco R. Souza
  • Publication number: 20120171744
    Abstract: A material comprising positively and negatively charged nanoparticles, wherein one of said nanoparticles contained a magnetically responsive element, are combined with a support molecule, which is a long natural or synthetic molecule or polymer to make a magnetic nanoparticle assembly. When the magnetic nanoparticle assembly is combined with cells, it will magnetize those cells. The magnetized cells can then be washed to remove the magnetic nanoparticle assembly and the magnetized cells manipulated in a magnetic field.
    Type: Application
    Filed: September 27, 2010
    Publication date: July 5, 2012
    Applicant: N3D BIOSCIENCES, INC.
    Inventor: Glauco R. Souza
  • Publication number: 20110286975
    Abstract: Systems and methods generally useful in medicine, cellular biology, nanotechnology, and cell culturing are discussed. In particular, at least in some embodiments, systems and methods for magnetic guidance and patterning of cells and materials are discussed. Some specific applications of these systems and methods may include levitated culturing of cells away from a surface, making and manipulating patterns of levitated cells, and patterning culturing of cells on a surface. Specifically, a method of culturing cells is presented. The method may comprise providing a plurality of cells, providing a magnetic field, and levitating at least some of the plurality of cells in the magnetic field, wherein the plurality of cells comprise magnetic nanoparticles. The method may also comprise maintaining the levitation for a time sufficient to permit cell growth to form an assembly.
    Type: Application
    Filed: March 24, 2011
    Publication date: November 24, 2011
    Inventors: Glauco R. Souza, Renata Pasqualini, Wadih Arap, Thomas Charles Killian, Robert M. Raphael, Daniel Joshua Stark
  • Publication number: 20040038264
    Abstract: This invention provides an apparatus and method that employs angle dependent light scattering combined with fractal dimension analysis of nanoparticle aggregates of gold and biopolymers, such as protein and nucleic acids, for detection and structural and functional characterization of unknown biopolymers. This is accomplished by detecting ADLS signal changes resulting from Au-biopolymer aggregate formation or from changes in fractal structure of Au-biopolymer aggregates as they specifically interact with other biopolymers. This invention describes an angle dependent light scattering apparatus that provides a sensitive, non-destructive, and dynamic measurement of the fractal dimension of Au-biopolymer aggregates, and provides a means for interpreting those measurements to allow identification of unknown nucleotides. A scattering cell is also provided.
    Type: Application
    Filed: May 13, 2003
    Publication date: February 26, 2004
    Inventors: Glauco R. Souza, J. Houston Miller