Patents by Inventor Glen Delbert Antwiler

Glen Delbert Antwiler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200291346
    Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
    Type: Application
    Filed: June 1, 2020
    Publication date: September 17, 2020
    Applicant: Terumo BCT, Inc.
    Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA
  • Patent number: 10669519
    Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: June 2, 2020
    Assignee: Terumo BCT, Inc.
    Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina
  • Patent number: 10577582
    Abstract: This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: March 3, 2020
    Assignee: Terumo BCT, Inc.
    Inventors: Glen Delbert Antwiler, David A. Windmiller, Monique Givens
  • Publication number: 20170335270
    Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
    Type: Application
    Filed: August 7, 2017
    Publication date: November 23, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA
  • Publication number: 20170267966
    Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
    Type: Application
    Filed: May 31, 2017
    Publication date: September 21, 2017
    Applicant: Terumo BCT, Inc.
    Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA
  • Patent number: 9725689
    Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: August 8, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina
  • Patent number: 9677042
    Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: June 13, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina
  • Patent number: 9670451
    Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: June 6, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas G. Dilorenzo, Edward Allan Stanton, IV, Glen Delbert Antwiler, Michael E. Kinzie, Brian J. Nankervis, Monique Givens, Casey V. Medina, Jon A. Dodd
  • Publication number: 20160304831
    Abstract: This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.
    Type: Application
    Filed: June 28, 2016
    Publication date: October 20, 2016
    Applicant: Terumo BCT, Inc.
    Inventors: Glen Delbert ANTWILER, David A. WINDMILLER, Monique GIVENS
  • Patent number: 9428729
    Abstract: This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: August 30, 2016
    Assignee: Terumo BCT, Inc.
    Inventors: Glen Delbert Antwiler, David A. Windmiller, Monique Givens
  • Patent number: 9284523
    Abstract: A premounted fluid conveyance assembly for use with a cell expansion machine comprises a tubing-organizer and a fluid conveyance system. The fluid conveyance system is at least partially attached to the tubing-organizer, and the fluid conveyance system comprises an oxygenator or gas transfer module, a length of tubing and a bioreactor all fluidly interconnected. The premounted fluid conveyance assembly is adapted to be detachably-attached to the cell expansion machine. Accordingly, after a premounted fluid conveyance assembly is used, it is removed from the cell expansion machine by disengaging it from the cell expansion machine. Thereafter, another premounted fluid conveyance assembly can be attached in place of the previously used premounted fluid conveyance assembly.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: March 15, 2016
    Assignee: Terumo BCT, Inc.
    Inventors: Jon A. Dodd, Thomas G. Dilorenzo, Frank Corbin, III, Glen Delbert Antwiler
  • Patent number: 9260698
    Abstract: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: February 16, 2016
    Assignee: Terumo BCT, Inc.
    Inventor: Glen Delbert Antwiler
  • Publication number: 20150079664
    Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
    Type: Application
    Filed: November 20, 2014
    Publication date: March 19, 2015
    Applicant: TERUMO BCT, INC.
    Inventors: Thomas G. DILORENZO, Edward Allan STANTON, IV, Glen Delbert ANTWILER, Michael E. KINZIE, Brian J. NANKERVIS, Monique GIVENS, Casey V. MEDINA, Jon A. DODD
  • Publication number: 20150024492
    Abstract: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.
    Type: Application
    Filed: July 21, 2014
    Publication date: January 22, 2015
    Applicant: TERUMO BCT, INC.
    Inventor: Glen Delbert ANTWILER
  • Publication number: 20150011004
    Abstract: Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having a particular orientation and shape, e.g., conical, to create a media-rich reservoir for growing cells. By placing the chamber in a vertical position, the force of media flow along the chamber walls is substantially equal and opposite to the gravitational force on the cells. The interaction of these forces maintains the non-adherent cells in suspension. The use of the cell growth chamber in conjunction with the mass transfer device and fluid circulation loop(s) creates efficiencies by relying on the cumulative and combined features of the devices.
    Type: Application
    Filed: September 22, 2014
    Publication date: January 8, 2015
    Applicant: Terumo BCT, Inc.
    Inventor: Glen Delbert ANTWILER
  • Patent number: 8906688
    Abstract: Cell expansion systems are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second fluid flow paths associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. The hollow fibers have a hydrophilic interior surface and a hydrophobic exterior surface. Detachable flow circuits are also provided.
    Type: Grant
    Filed: April 14, 2008
    Date of Patent: December 9, 2014
    Assignee: Terumo BCT, Inc.
    Inventor: Glen Delbert Antwiler
  • Patent number: 8895291
    Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
    Type: Grant
    Filed: October 7, 2011
    Date of Patent: November 25, 2014
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas G. Dilorenzo, Edward Allan Stanton, IV, Glen Delbert Antwiler, Michael E. Kinzie, Brian J. Nankervis, Monique Givens, Casey V. Medina, Jon A. Dodd
  • Patent number: 8841122
    Abstract: Embodiments described herein generally relate to systems and methods for promoting the expansion of high density non-adherent cells through the use of a cell growth chamber, a mass transfer device, and a fluid circulation loop. Improved cell growth is achieved in the cell growth chamber by using a chamber having a particular orientation and shape, e.g., conical, to create a media-rich reservoir for growing cells. By placing the chamber in a vertical position, the force of media flow along the chamber walls is substantially equal and opposite to the gravitational force on the cells. The interaction of these forces maintains the non-adherent cells in suspension. The use of the cell growth chamber in conjunction with the mass transfer device and fluid circulation loop(s) creates efficiencies by relying on the cumulative and combined features of the devices.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: September 23, 2014
    Assignee: Terumo BCT, Inc.
    Inventor: Glen Delbert Antwiler
  • Patent number: 8785181
    Abstract: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: July 22, 2014
    Assignee: Terumo BCT, Inc.
    Inventor: Glen Delbert Antwiler
  • Publication number: 20140178995
    Abstract: This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.
    Type: Application
    Filed: February 27, 2014
    Publication date: June 26, 2014
    Applicant: Terumo BCT, Inc.
    Inventors: Glen Delbert ANTWILER, David A. WINDMILLER, Monique GIVENS