Patents by Inventor Glen Delbert Antwiler
Glen Delbert Antwiler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
Patent number: 11773363Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.Type: GrantFiled: December 2, 2022Date of Patent: October 3, 2023Assignee: Terumo BCT, Inc.Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina -
Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
Patent number: 11746319Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.Type: GrantFiled: June 1, 2020Date of Patent: September 5, 2023Assignee: Terumo BCT, Inc.Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina -
Configurable Methods And Systems Of Growing And Harvesting Cells In A Hollow Fiber Bioreactor System
Publication number: 20230102100Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.Type: ApplicationFiled: December 2, 2022Publication date: March 30, 2023Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA -
Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
Patent number: 11613727Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.Type: GrantFiled: September 30, 2020Date of Patent: March 28, 2023Assignee: Terumo BCT, Inc.Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina -
Configurable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System
Publication number: 20210024876Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.Type: ApplicationFiled: September 30, 2020Publication date: January 28, 2021Applicant: Terumo BCT, Inc.Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA -
Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
Patent number: 10870827Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.Type: GrantFiled: August 7, 2017Date of Patent: December 22, 2020Assignee: Terumo BCT, Inc.Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina -
Customizable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System
Publication number: 20200291346Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.Type: ApplicationFiled: June 1, 2020Publication date: September 17, 2020Applicant: Terumo BCT, Inc.Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA -
Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
Patent number: 10669519Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.Type: GrantFiled: May 31, 2017Date of Patent: June 2, 2020Assignee: Terumo BCT, Inc.Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina -
Patent number: 10577582Abstract: This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.Type: GrantFiled: June 28, 2016Date of Patent: March 3, 2020Assignee: Terumo BCT, Inc.Inventors: Glen Delbert Antwiler, David A. Windmiller, Monique Givens
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Configurable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System
Publication number: 20170335270Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.Type: ApplicationFiled: August 7, 2017Publication date: November 23, 2017Applicant: Terumo BCT, Inc.Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA -
Customizable Methods and Systems of Growing and Harvesting Cells in a Hollow Fiber Bioreactor System
Publication number: 20170267966Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.Type: ApplicationFiled: May 31, 2017Publication date: September 21, 2017Applicant: Terumo BCT, Inc.Inventors: Edward Allan STANTON, IV, Glen Delbert ANTWILER, Patrick J. HOWLEY, Michael E. KINZIE, Jon A. DODD, Casey V. MEDINA -
Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
Patent number: 9725689Abstract: Embodiments described herein generally relate to methods and systems for configuring settings of a cell expansion system including a bioreactor. Through a user interface, a user may configure display settings, system settings, and settings associated with protocols for loading, growing and/or harvesting cells. In configuring settings for protocols and associated processes, a diagram view or window of the cell expansion system is displayed in embodiments. The diagram view displays the process settings as graphical user interface elements. Settings available for configuration are enabled for selection in the diagram view. The diagram view allows the user to visualize the settings available for task configuration and to configure enabled settings. Configured settings are stored and capable of retrieval for subsequent execution or modification of the applicable protocol.Type: GrantFiled: October 7, 2011Date of Patent: August 8, 2017Assignee: Terumo BCT, Inc.Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina -
Customizable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system
Patent number: 9677042Abstract: Embodiments described herein generally relate to methods and systems for customizing protocols for use with a cell expansion system. Through a user interface, a user may create a custom task for loading, growing and/or harvesting cells. A custom task may comprise one or more steps, in which a user may add or omit steps, as desired. Data may be entered for settings associated with a custom task, in which embodiments provide for such data to be entered each time the custom task is performed. In another embodiment, the settings for a custom task may be configured, in which such settings may be stored and retrieved upon selection of the custom task. Customization and configuration of a custom task may occur using a diagram view of the cell expansion system, in which process settings are associated with graphical user interface elements.Type: GrantFiled: October 7, 2011Date of Patent: June 13, 2017Assignee: Terumo BCT, Inc.Inventors: Edward Allan Stanton, IV, Glen Delbert Antwiler, Patrick J. Howley, Michael E. Kinzie, Jon A. Dodd, Casey V. Medina -
Patent number: 9670451Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.Type: GrantFiled: November 20, 2014Date of Patent: June 6, 2017Assignee: Terumo BCT, Inc.Inventors: Thomas G. Dilorenzo, Edward Allan Stanton, IV, Glen Delbert Antwiler, Michael E. Kinzie, Brian J. Nankervis, Monique Givens, Casey V. Medina, Jon A. Dodd
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Publication number: 20160304831Abstract: This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.Type: ApplicationFiled: June 28, 2016Publication date: October 20, 2016Applicant: Terumo BCT, Inc.Inventors: Glen Delbert ANTWILER, David A. WINDMILLER, Monique GIVENS
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Patent number: 9428729Abstract: This invention is directed to methods of directly reseeding harvested adherent cells grown in a hollow fiber bioreactor. Also disclosed is a novel harvest media for use in directly reseeding adherent cells into a hollow fiber bioreactor.Type: GrantFiled: February 27, 2014Date of Patent: August 30, 2016Assignee: Terumo BCT, Inc.Inventors: Glen Delbert Antwiler, David A. Windmiller, Monique Givens
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Patent number: 9284523Abstract: A premounted fluid conveyance assembly for use with a cell expansion machine comprises a tubing-organizer and a fluid conveyance system. The fluid conveyance system is at least partially attached to the tubing-organizer, and the fluid conveyance system comprises an oxygenator or gas transfer module, a length of tubing and a bioreactor all fluidly interconnected. The premounted fluid conveyance assembly is adapted to be detachably-attached to the cell expansion machine. Accordingly, after a premounted fluid conveyance assembly is used, it is removed from the cell expansion machine by disengaging it from the cell expansion machine. Thereafter, another premounted fluid conveyance assembly can be attached in place of the previously used premounted fluid conveyance assembly.Type: GrantFiled: October 26, 2009Date of Patent: March 15, 2016Assignee: Terumo BCT, Inc.Inventors: Jon A. Dodd, Thomas G. Dilorenzo, Frank Corbin, III, Glen Delbert Antwiler
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Patent number: 9260698Abstract: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.Type: GrantFiled: July 21, 2014Date of Patent: February 16, 2016Assignee: Terumo BCT, Inc.Inventor: Glen Delbert Antwiler
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Publication number: 20150079664Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.Type: ApplicationFiled: November 20, 2014Publication date: March 19, 2015Applicant: TERUMO BCT, INC.Inventors: Thomas G. DILORENZO, Edward Allan STANTON, IV, Glen Delbert ANTWILER, Michael E. KINZIE, Brian J. NANKERVIS, Monique GIVENS, Casey V. MEDINA, Jon A. DODD
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Publication number: 20150024492Abstract: Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively. Detachable flow circuits and methods of expanding cells are also provided.Type: ApplicationFiled: July 21, 2014Publication date: January 22, 2015Applicant: TERUMO BCT, INC.Inventor: Glen Delbert ANTWILER