Patents by Inventor Glen Deleavey

Glen Deleavey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof
    Patent number: 9719091
    Abstract: Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2?-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2?-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
    Type: Grant
    Filed: July 27, 2015
    Date of Patent: August 1, 2017
    Assignee: Paladin Labs, Inc.
    Inventors: Masad J. Damha, Jonathan K. Watts, Glen Deleavey
  • Method for reducing expression of downregulated in renal cell carcinoma in malignant gliomas
    Patent number: 9493772
    Abstract: The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or RNAs or vectors encoding them which reduce expression of downregulated in renal cell carcinoma (DRR) in tumor cells, and inhibit malignant glioma cell invasion.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: November 15, 2016
    Assignee: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
    Inventors: Kevin Petrecca, Masad Damha, Glen Deleavey
  • OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF
    Publication number: 20160145613
    Abstract: Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2?-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2?-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
    Type: Application
    Filed: July 27, 2015
    Publication date: May 26, 2016
    Inventors: Masad J. Damha, Jonathan K. Watts, Glen Deleavey
  • Oligonucleotide duplexes comprising DNA-like and RNA-like nucleotides and uses thereof
    Patent number: 9090649
    Abstract: Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2?-sub-stituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2?-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
    Type: Grant
    Filed: June 5, 2009
    Date of Patent: July 28, 2015
    Assignee: Paladin Labs, Inc.
    Inventors: Masad J. Damha, Jonathan K. Watts, Glen Deleavey
  • METHOD FOR REDUCING EXPRESSION OF DOWNREGULATED IN RENAL CELL CARCINOMA IN MALIGNANT GLIOMAS
    Publication number: 20140343124
    Abstract: The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or RNAs or vectors encoding them which reduce expression of downregulated in renal cell carcinoma (DRR) in tumor cells, and inhibit malignant glioma cell invasion.
    Type: Application
    Filed: May 22, 2014
    Publication date: November 20, 2014
    Applicant: The Royal Institution for The Advancement of Learning/McGill University
    Inventors: Kevin PETRECCA, Masad DAMHA, Glen DELEAVEY
  • OLIGONUCLEOTIDE DUPLEXES COMPRISING DNA-LIKE AND RNA-LIKE NUCLEOTIDES AND USES THEREOF
    Publication number: 20110077286
    Abstract: Novel oligonucleotide pairs which can form a duplex comprising one or more DNA-like nucleotides (e.g., 2?-substituted arabinonucleotides (ANA)); in combination with one or more RNA-like nucleotides (e.g., 2?-substituted ribonucleotides (RNA) and/or locked nucleic acid nucleotides (LNA)), are disclosed. The use of such oligonucleotide duplexes, such as for silencing the expression of a nucleic acid or gene of interest using small interfering RNA (siRNA) technologies, is also disclosed.
    Type: Application
    Filed: June 5, 2009
    Publication date: March 31, 2011
    Inventors: Masad J. Damha, Jonathan K. Watts, Glen Deleavey